6-(naphthalen-2-yloxy)hexanoic acid | 172087-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-(naphthalen-2-yloxy)hexanoic acid
• 英文别名: 6-(2-naphthoxy)hexanoic acid；6-[2]naphthyloxy-hexanoic acid；6-[2]Naphthyloxy-hexansaeure；6-Naphthalen-2-yloxyhexanoic acid
• CAS: 172087-33-1
• 化学式: C₁₆H₁₈O₃
• mdl: MFCD20055997
• 分子量: 258.317
• InChiKey: MORRWGXXSRSUNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.312
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(naphthalen-2-yloxy)hexanoic acid 、 2-胺基乙酸乙酯 在 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以80%的产率得到[6-(naphthalen-2-yloxy)hexanoylamino]acetic acid ethyl ester
  参考文献：
  名称：

  Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB₂-selective ligands

  摘要：

  在这里，我们报告了合成具有延长侧链的萘、二氢苯并二恶烷和芴衍生物，并对它们进行了作为CB₁和CB₂受体配体的生物评价。

  DOI：

  10.1039/c4md00232f
• 作为产物：
  描述：

  6-[2]naphthyloxy-hexanenitrile 在 氢氧化钾 作用下， 生成 6-(naphthalen-2-yloxy)hexanoic acid
  参考文献：
  名称：

  合成植物生长调节剂。第三部分 ω-2-萘氧基链烷羧酸

  摘要：

  DOI：

  10.1039/jr9540001721

文献信息

• Monoclonal Antibody-Based ELISAs for Part-per-Billion Determination of Polycyclic Aromatic Hydrocarbons:  Effects of Haptens and Formats on Sensitivity and Specificity
  作者：Kai Li、Rongliang Chen、Bitao Zhao、Mei Liu、Alexander E. Karu、Victoria A. Roberts、Qing X. Li

  DOI：10.1021/ac980765d

  日期：1999.1.1

  As a first step toward developing sensitive enzyme-linked immunosorbent assays (ELISAs) for multianalyte detection of polycyclic aromatic hydrocarbons (PAHs), haptens with different lengths of carboxylic acid spacers at various positions were derived from naphthalene, fluorene, anthracene, phenanthrene, pyrene, fluoranthene, chrysene, and benzo[a]pyrene (BaP). These haptens were coupled with bovine serum albumin (BSA) to form competitor conjugates. All of these haptens were recognized to different extents by monoclonal antibodies (MAbs) 4D5 and 10C10 originally derived by Gomes and Santella (Chem. Res. Toxicol. 1990, 3, 307−310). The most sensitive indirect ELISAs were obtained by coating wells with the least competitive conjugates. Direct ELISAs using horseradish peroxidase conjugates of pyrene and BaP were less sensitive. The MAbs bound BaP with spacers at either C1 or C6. The cross-reactivity profiles of the eight PAHs were different with each PAH−BSA conjugate used as coating antigen. The ELISA results for BaP closely correlated with those by gas chromatography (GC), but the detection limit of the ELISA was ∼150-fold more sensitive than that of GC, with 2−600 nM spike recoveries of 80−127% from human urine and canal and tap water.

  作为开发灵敏的酶联免疫吸附测定法（ELISA）以检测多环芳烃（PAHs）的第一步，我们从萘、芴、蒽、菲、芘、荧蒽、菊烯和苯并[a]芘（BaP）中提取出了在不同位置具有不同长度羧酸间隔的触媒。这些触媒与牛血清白蛋白（BSA）结合形成竞争共轭物。Gomes 和 Santella 最初研制的单克隆抗体（MAbs）4D5 和 10C10 可在不同程度上识别所有这些触媒（《化学研究与毒理学》，1990 年 3 期，307-310 页）。用竞争性最小的共轭物涂布孔，可获得灵敏度最高的间接 ELISA。使用芘和 BaP 的辣根过氧化物酶结合物进行直接 ELISA 的灵敏度较低。MAbs 在 C1 或 C6 处与带有间隔的 BaP 结合。八种多环芳烃的交叉反应谱与用作包被抗原的每种多环芳烃-BSA 结合物都不同。酶联免疫吸附法检测 BaP 的结果与气相色谱法（GC）的结果密切相关，但酶联免疫吸附法的检测限比气相色谱法灵敏 150 倍，在人体尿液、运河水和自来水中 2-600 nM 的峰值回收率为 80-127%。
• Photoionization Studies of Chromophore-Labeled Amino Acids and Peptides
  作者：Christopher T. Houston、James P. Reilly

  DOI：10.1021/jp001246t

  日期：2000.11.1

  of a naphthol chromophore covalently tethered to a few different amino acids and small peptides are investigated. To isolate the chromophore from the biological molecules the linkage between them is constructed from saturated alkyl chains of up to 12 carbons in length. Experimental results are compared with those of previous studies that explored the photoionization of macromolecules.

  研究了与几种不同氨基酸和小肽共价连接的萘酚发色团的光电离特性。为了从生物分子中分离发色团，它们之间的连接由最长 12 个碳原子的饱和烷基链构成。实验结果与之前探索大分子光电离的研究的结果进行了比较。
• HYPERBRANCHED POLYMERS FOR ORGANIC PIGMENT DISPERSIONS AND WATER-SENSITIVE PIGMENTS
  申请人：BASF Coatings GmbH

  公开号：US20190106592A1

  公开（公告）日：2019-04-11

  Aryl-modified hyperbranched polyols are described, as are coating compositions containing these polyols. These polyols enable waterborne coating compositions that: include water-sensitive pigments; are storage stable; and have a low content of VOCs, as well as solventborne coating compositions that: include organic pigments; are storage stable; and enable certain enhanced color properties.
• Synthesis of plant-growth regulators. Part III. ω-2-Naphthyloxyalkanecarboxylic acids
  作者：P. M. Pope、D. Woodcock

  DOI：10.1039/jr9540001721

  日期：——
• Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB₂-selective ligands
  作者：Noha A. Osman、Amr H. Mahmoud、Christian D. Klein、Marco Allarà、Vincenzo Di Marzo、Khaled M. Abouzid、Ashraf H. Abadi

  DOI：10.1039/c4md00232f

  日期：——

  Herein, we report the synthesis of naphthalene, dihydrobenzodioxine and fluorene derivatives with extended side chains and their biological evaluation as ligands of CB₁ and CB₂ receptors.

  在这里，我们报告了合成具有延长侧链的萘、二氢苯并二恶烷和芴衍生物，并对它们进行了作为CB₁和CB₂受体配体的生物评价。