N-propyl-p-phenylenediamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-propyl-p-phenylenediamine
• 英文别名: N-Propyl-p-phenylendiamin；N-Propyl-p-phenylendiamin；4-N-propylbenzene-1,4-diamine
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: GGJDRBODPQEEHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 tin(ll) chloride 作用下， 生成 N-propyl-p-phenylenediamine
  参考文献：
  名称：

  Wacker, Justus Liebigs Annalen der Chemie, 1888, vol. 243, p. 298

  摘要：

  DOI：

文献信息

• [EN] SILICA-BASED ZINC CATALYSTS. THEIR PREPARATION AND USE IN THE ALKOXYCARBONYLATION OF AMINES<br/>[FR] CATALYSEURS AU ZINC À BASE DE SILICE, LEUR PRÉPARATION ET LEUR UTILISATION DANS L'ALCOXYCARBONYLATION D'AMINES
  申请人：COVESTRO DEUTSCHLAND AG

  公开号：WO2018210711A1

  公开（公告）日：2018-11-22

  The present invention relates to silica-based heterogeneous zinc compounds which are suitable as catalysts in the reaction of amines with dialkyl carbonates to produce carbamates. The catalysts have the formula [SiO2]-CH2-CHR-X-COOZn[Y], wherein [SiO2] represents a silica carrier selected from the group consisting of ordered mesoporous silica and irregular amorphous narrow pore silica, R represents a moiety selected from the group consisting of hydrogen, -CH3, and -CH2CH3, preferably hydrogen, X is an aliphatic chain of 2 to 11 carbon atoms that optionally comprises ether moieties and [Y] represents a mono anion. The invention is also directed towards a method for the preparation of the aforementioned compounds and towards method for the alkoxycarbonylation of amines.

  本发明涉及硅基杂化锌化合物，适用于作为催化剂在胺与二烷基碳酸酯反应中产生氨基甲酸酯。催化剂的化学式为[SiO2]-CH2-CHR-X-COOZn[Y]，其中[SiO2]代表从有序介孔硅和不规则非晶窄孔硅组成的硅载体，R代表从氢、-CH3和-CH2CH3组成的基团，优选为氢，X是由2至11个碳原子组成的脂肪链，可选地包含醚基团，[Y]代表单阴离子。该发明还涉及上述化合物的制备方法以及胺的烷氧羰基化方法。
• [EN] COMPOUNDS FOR TARGETED DEGRADATION OF BRD9<br/>[FR] COMPOSÉS POUR LA DÉGRADATION CIBLÉE DE LA BRD9
  申请人：C4 THERAPEUTICS INC

  公开号：WO2021178920A1

  公开（公告）日：2021-09-10

  BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.

  提供了用于治疗由BRD9介导的疾病的BRD9蛋白降解化合物或其药用盐，包括但不限于异常细胞增殖。
• Phenylene-Bis-Oxazolidine Derivatives and Their Use as Anticoagulants
  申请人：Rohrig Susanne

  公开号：US20100041646A1

  公开（公告）日：2010-02-18

  The present application relates to novel 1,4-phenylene-bis-oxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.

  本申请涉及新颖的1,4-苯基-双噁唑啉衍生物，以及它们的制备方法，用于治疗和/或预防疾病的用途，以及用于制备治疗和/或预防疾病的药物，特别是血栓栓塞性疾病。
• Iminooxazolidine Derivatives and Their Use
  申请人：Rohrig Susanne

  公开号：US20100004292A1

  公开（公告）日：2010-01-07

  The present application relates to novel iminooxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.

  本申请涉及新型亚胺噁唑啉衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备治疗和/或预防疾病的药物，特别是血栓栓塞性疾病。
• [EN] HETEROGENEOUS CATALYSTS FOR THE SYNTHESIS OF CARBAMATES<br/>[FR] CATALYSEURS HÉTÉROGÈNES POUR LA SYNTHÈSE DES CARBAMATES
  申请人：COVESTRO DEUTSCHLAND AG

  公开号：WO2019185608A1

  公开（公告）日：2019-10-03

  The present invention relates to a catalyst for preparing carbamates, in particular aromatic carbamates, comprising a binary oxide having the formula Li_xMx02, wherein 1. is a metal selected from the lanthanoid series and M is a metal selected from the group consisting of Sc, Y, Ti, Zr, Hf, metals from the lanthanoid series and metals from the actinoid series, and wherein x ranges from 0.01 to 0.05. The present invention also relates to a method for producing said catalysts and a method of utilizing said catalysts in the production of carbamates, in particular aromatic carbamates.

  本发明涉及一种用于制备氨基甲酸酯催化剂，特别是芳香族氨基甲酸酯的催化剂，包括具有Li_xMxO2式的二元氧化物，其中1.是从镧系金属中选择的金属，M是从Sc、Y、Ti、Zr、Hf、镧系金属和锕系金属组成的金属中选择的金属，并且x范围从0.01到0.05。本发明还涉及一种制备所述催化剂的方法以及利用所述催化剂制备氨基甲酸酯，特别是芳香族氨基甲酸酯的方法。