2-Chloro-1,1,2,2-tetrafluoroethyl trifluoromethyl ether | 1561-50-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 2-Chloro-1,1,2,2-tetrafluoroethyl trifluoromethyl ether
• 英文别名: <2-Chlor-1,1,2,2-tetrafluor-ethyl>-trifluormethyl-ether；(2-Chlor-1,1,2,2-tetrafluorethyl)-trifluormethyl-ether；Trifluormethyl-1,1,2,2-tetrafluor-2-chloraethylaether；2-Chlortetrafluorethyltrifluormethylether；1-Chloro-1,1,2,2-tetrafluoro-2-(trifluoromethoxy)ethane
• CAS: 1561-50-8
• 化学式: C₃ClF₇O
• 分子量: 220.474
• InChiKey: KBVRCFVKEVGGSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-Chloro-1,1,2,2-tetrafluoroethyl trifluoromethyl ether 、 chlorine fluorosulfate 以90%的产率得到
  参考文献：
  名称：

  SCHACK C. J.; CHRISTE K. O., J. FLUOR. CHEM., 1979, 14, NO 6, 519-522

  摘要：

  DOI：
• 作为产物：
  描述：

  silver perfluoromethoxybutyrate 在 氯 作用下， 生成 2-Chloro-1,1,2,2-tetrafluoroethyl trifluoromethyl ether
  参考文献：
  名称：

  Tumanov,A.V. et al., Journal of general chemistry of the USSR, 1965, vol. 35, p. 585

  摘要：

  DOI：

文献信息

• Fluorination of Chlorinated Trifluoromethyl Ethers
  作者：Akira Sekiya、Kunimasa Ueda

  DOI：10.1246/cl.1991.1421

  日期：1991.8

  Chlorine atoms in the chlorinated trifluoromethyl ether prepared from the reaction between chlorinated ethylenes and trifluoromethyl hypofluorite were fluorinated directly by fluorine gas. Tin(II) fluoride/sodium fluoride system was effective in the fluorination.

  氯化乙烯与三氟甲基次氟酸盐反应制得的氯化三氟甲基醚中的氯原子被氟气直接氟化。氟化锡（II）/氟化钠体系在氟化中是有效的。
• Practical preparation of potentially anesthetic fluorinated ethyl methyl ethers by means of bromine trifluoride and other methods
  作者：Tomas Hudlicky、Caiming Duan、Josephine W Reed、Fengyang Yan、Milos Hudlicky、Mary Ann Endoma、Edmond I Eger

  DOI：10.1016/s0022-1139(99)00302-4

  日期：2000.3

  Synthetic methods, especially those that use bromine trifluoride as a fluorinating agent, are described for the preparation of a number of fluorinated ethyl methyl ethers in good yield and high purity. In all cases, medium-scale syntheses (8–22 g) of potentially anesthetic compounds have been accomplished. The compounds are of sufficient purity (>99%) for biological evaluation.

  描述了合成方法，特别是使用三氟化溴作为氟化剂的合成方法，以高收率和高纯度制备许多氟化乙基甲基醚。在所有情况下，已经完成了中等规模的合成（8–22 g）潜在的麻醉剂。这些化合物具有足够的纯度（> 99％）用于生物学评估。
• Relative Rate Constants for the Reactions of CF3OF with Olefins in Solution
  作者：W. Navarrini、A. Russo、V. Tortelli

  DOI：10.1021/jo00125a033

  日期：1995.10

  The addition reactions of CF3OF to chloro fluoro olefins have been studied in solution at low temperature (-78, -105 degrees C), and their relative rate constants have been determined using the kinetic approach of competition reactions. The reactivity and regio- and stereoselectivity are consistent with a free radical chain-propagating reaction in which the alkenes are attacked by the CF3O. radical generated by homolitic cleavage of the O-F bond in the CF3OF molecule.
• Perhaloalkyl hypochlorites and pentafluorosulfur hypochlorite. IV. Reactions with olefins
  作者：Lowell Ray Anderson、David Edward Young、Douglas E. Gould、R. Juurik-Hogan、D. Neuchterlein、William B. Fox

  DOI：10.1021/jo00836a032

  日期：1970.11