3-diethylamino-1-[1]naphthyl-propan-1-one; hydrochloride | 5471-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-diethylamino-1-[1]naphthyl-propan-1-one; hydrochloride
• 英文别名: 3-Diaethylamino-1-[1]naphthyl-propan-1-on; Hydrochlorid；3-diethylamino-1-(1-naphthyl)-propan-1-one hydrochloride；3-(Diethylamino)-1-naphthalen-1-ylpropan-1-one;hydrochloride
• CAS: 5471-14-7
• 化学式: C₁₇H₂₁NO*ClH
• 分子量: 291.821
• InChiKey: UEPDEEQTMMXREG-UHFFFAOYSA-N

物化性质

• 熔点：
  141-142 °C

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  20.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922399090

反应信息

• 作为产物：
  描述：

  1-萘乙酮 、 聚合甲醛 、 二乙胺盐酸盐 在 乙醇 作用下， 生成 3-diethylamino-1-[1]naphthyl-propan-1-one; hydrochloride
  参考文献：
  名称：

  CERTAIN KETONIC MANNICH BASES DERIVED FROM 1- AND 2- ACETONAPHTHONE

  摘要：

  DOI：

  10.1021/jo01136a020

文献信息

• [EN] UROTENSIN II RECEPTOR MODULATORS<br/>[FR] MODULATEURS DU RECEPTEUR DE L'UROTENSINE II
  申请人：ACADIA PHARM INC

  公开号：WO2003104216A1

  公开（公告）日：2003-12-18

  Disclosed are compounds of Formula I, or salts or prodrugs thereof, complexed with a human urotensin II receptor as defined herein. Also disclosed are compounds of Formula II, or salts or prodrugs thereof, as defined herein. Also disclosed are methods of modulating the activity of a urotensin II receptor using a compound of Formula I, or a compound of Formula II, or salts or prodrugs thereof. In addition, methods of treating diseases related to the activity of urotensin II receptors are disclosed.

  本文披露了根据本文所定义的与人类尿嘧啶 II 受体形成络合物的 Formula I 化合物，或其盐或前药。还披露了根据本文所定义的 Formula II 化合物，或其盐或前药。还披露了使用 Formula I 化合物、Formula II 化合物、或其盐或前药来调节尿嘧啶 II 受体活性的方法。此外，还披露了治疗与尿嘧啶 II 受体活性相关疾病的方法。
• Facile catalyst-free synthesis of 2-vinylquinolines via a direct deamination reaction occurring during Mannich synthesis
  作者：Jichao Xiao、Ye Huang、Zilan Song、Wenhua Feng

  DOI：10.1039/c5ra21304e

  日期：——

  A facile catalyst-free method for the synthesis of 2-vinylquinolines via a direct deamination reaction during Mannich synthesis has been developed.

  一种简便的无催化剂方法已经开发出来，用于在Mannich合成过程中通过直接脱氨化反应合成2-乙烯基喹啉。
• Urotensin II receptor agents
  申请人：——

  公开号：US20040077529A1

  公开（公告）日：2004-04-22

  Disclosed are compounds of Formula I, or salts or prodrugs thereof, complexed with a human urotensin II receptor 1 as defined herein. Also disclosed are compounds of Formula II, or salts or prodrugs thereof, 2 as defined herein. Also disclosed are methods of modulating the activity of a urotensin II receptor using a compound of Formula I, or a compound of Formula II, or salts or prodrugs thereof. In addition, methods of treating diseases related to the activity of urotensin II receptors are disclosed.
• CERTAIN KETONIC MANNICH BASES DERIVED FROM 1- AND 2- ACETONAPHTHONE
  作者：S. W. PELLETIER

  DOI：10.1021/jo01136a020

  日期：1952.2