4-(benzyloxy)-2-cyclopropylbenzofuran | 1449688-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 4-(benzyloxy)-2-cyclopropylbenzofuran
• CAS: 1449688-03-2
• 化学式: C₁₈H₁₆O₂
• 分子量: 264.324
• InChiKey: PGOVPMJWWIEBRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  22.37
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  4-(benzyloxy)-2-cyclopropylbenzofuran 、 1-萘甲酰氯 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 以35%的产率得到(2-cyclopropyl-4-hydroxybenzofuran-3-yl)(naphthalen-1-yl)methanone
  参考文献：
  名称：

  Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth

  摘要：

  A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Tiypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.07.002
• 作为产物：
  描述：

  2-碘苯-1,3-二醇 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 potassium carbonate 、 三乙胺 作用下， 以 丙酮 、 乙腈 为溶剂， 生成 4-(benzyloxy)-2-cyclopropylbenzofuran
  参考文献：
  名称：

  Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth

  摘要：

  A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Tiypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.07.002