二甲氨基-1甲氧基-4丁烷 | 33962-95-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 二甲氨基-1甲氧基-4丁烷
• 英文名称: dimethylamino-1 methoxy-4 butane
• 英文别名: 4-methoxybutyldimethylamine；(4-methoxy-butyl)-dimethyl-amine；(4-Methoxy-butyl)-dimethyl-amin；1-Dimethylamino-4-methoxy-butan；Methyl-(δ-dimethylamino-butyl)-aether；Dimethyl-(δ-methoxy-butyl)-amin；4-methoxy-N,N-dimethylbutan-1-amine
• CAS: 33962-95-7
• 化学式: C₇H₁₇NO
• 分子量: 131.218
• InChiKey: ZNPJKSCIHJSEQZ-UHFFFAOYSA-N

物化性质

• 沸点：
  150 °C(Press: 765 Torr)
• 密度：
  0.8228 g/cm3(Temp: 19.9 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二甲氨基-1甲氧基-4丁烷 、 碘甲烷 生成 4-methoxybutyltrimethylammonium iodide
  参考文献：
  名称：

  Guermont, Bulletin de la Societe Chimique de France, 1953, p. 386,389

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基丁腈 在 乙醇 、 sodium 作用下， 生成 二甲氨基-1甲氧基-4丁烷
  参考文献：
  名称：

  Clarke, Journal of the Chemical Society, 1913, vol. 103, p. 1699

  摘要：

  DOI：

文献信息

• [EN] BRANCHED ALKYL AND CYCLOALKYL TERMINATED BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS<br/>[FR] LIPIDES BIODÉGRADABLES RAMIFIÉS À TERMINAISONS ALKYLE ET CYCLOALKYLE DESTINÉS À L'ADMINISTRATION D'AGENTS ACTIFS
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2013086322A1

  公开（公告）日：2013-06-13

  The present invention relates to a cationic lipid of formula (I) having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及具有一个或多个生物可降解基团的阳离子脂质的化学式(I)，所述生物可降解基团位于阳离子脂质的脂质部分（例如，疏水链）中。这些阳离子脂质可以被纳入脂质粒子中，用于传递活性剂，例如核酸。该发明还涉及包括中性脂质、能够减少聚集的脂质、本发明的阳离子脂质以及可选地固醇的脂质粒子。脂质粒子还可以进一步包括治疗剂，例如核酸。
• [EN] POLYNUCLEOTIDES FOR DISRUPTING IMMUNE CELL ACTIVITY AND METHODS OF USE THEREOF<br/>[FR] POLYNUCLÉOTIDES SERVANT À PERTURBER L'ACTIVITÉ DE CELLULE IMMUNITAIRE ET PROCÉDÉS POUR LES UTILISER
  申请人：MODERNATX INC

  公开号：WO2020227510A1

  公开（公告）日：2020-11-12

  The disclosure features isolated polynucleotides, such as mRNAs, encoding a polypeptide that disrupts immune cell activity, such as T cell or B cell activity, including mRNAs comprising one or more modified nucleobase. The immune cell disruptor polynucleotides encode a polypeptide that comprises a first domain that mediates association of the polypeptide with an immune cell component and a second domain that mediates inhibition of immune cell activity when the polypeptide is expressed in the immune cell. The disclosure also features methods of using the same, for example, for inhibiting immune responses when administered to a subject, such as to inhibit autoimmune reactions.

  该披露涉及孤立的多聚核苷酸，如编码破坏免疫细胞活性的多聚核苷酸，例如T细胞或B细胞活性的mRNA，包括包含一个或多个修饰的核碱基的mRNA。这些免疫细胞破坏多聚核苷酸编码一个包括第一个结构域的多肽，该结构域介导多肽与免疫细胞组分的结合，以及一个介导当多肽在免疫细胞中表达时抑制免疫细胞活性的第二结构域。该披露还涉及使用相同的方法，例如，将其用于向受试者施用时抑制免疫反应，例如用于抑制自身免疫反应。
• BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20160009637A1

  公开（公告）日：2016-01-14

  The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，其具有位于脂质基团（例如，疏水链）的中部或远端部位的一个或多个可生物降解的基团。这些阳离子脂质可以被纳入脂质颗粒中，用于传递活性剂，例如核酸。该发明还涉及包括中性脂质、能够减少聚集的脂质、本发明的阳离子脂质以及可选地固醇的脂质颗粒。脂质颗粒还可以进一步包含治疗剂，如核酸。
• Copper-Catalyzed Reaction of C₆₀ with Tertiary Amines for the Preparation of Spiro-Linked Methanofullerenes and Fullerenoalkanals
  作者：Yong-Jian Liu、Jie Ge、Chun-Bao Miao、Hai-Tao Yang

  DOI：10.1021/acs.joc.9b00335

  日期：2019.5.17

  CuI-catalyzed reaction of C60 with tertiary amines by using air as the sole oxidant has been developed. Spiro-linked methanofullerenes bearing cyclic amides and fullerenoalkanals can be obtained selectively using the cyclic and acyclic amines as starting materials, respectively. The reactions show a wide functional group tolerance. In addition, four ([6,6]-phenyl-C61-butyric acid methyl ester) analogues

  通过使用空气作为唯一的氧化剂，已开发出CuI催化的C 60与叔胺的反应。分别使用环状和非环状胺作为起始原料，可以选择性地获得带有环状酰胺和富勒烯烷醛的螺旋连接的甲基富勒烯。反应显示出宽泛的官能团耐受性。另外，通过开发的方法可以容易地制备四个（[6,6]-苯基-C 61-丁酸甲酯）类似物。
• C-MET PROTEIN KINASE INHIBITORS
  申请人：Lauffer David J.

  公开号：US20120165333A1

  公开（公告）日：2012-06-28

  The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.

  本发明涉及公式I的化合物，其可用于抑制c-Met蛋白激酶。本发明还提供了包含该发明化合物的药学上可接受的组合物，以及使用该组合物治疗增生性疾病的方法。