N'-tert-butyl-5-chlorochroman-6-carbohydrazide | 886997-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N'-tert-butyl-5-chlorochroman-6-carbohydrazide
• CAS: 886997-84-8
• 化学式: C₁₄H₁₉ClN₂O₂
• 分子量: 282.77
• InChiKey: RHNGZNHAUJMGDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.36
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N'-tert-butyl-5-chlorochroman-6-carbohydrazide 、 3-氯苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以68.2%的产率得到N'-tert-butyl-5-chloro-N'-(3-chlorobenzoyl)-3,4-dihydro-2H-chromene-6-carbohydrazide
  参考文献：
  名称：

  Synthesis and insecticidal evaluation of novel N′-tert-butyl-N′-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives

  摘要：

  A series of novel N'-tert-butyl- N'-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives were synthesized, and their larvicidal activities against Oriental armyworm were evaluated. The results of bioassays indicated that most of these title compounds exhibit higher larvicidal activities than RH-5849, and several of them somewhat lower than the commercial insecticide tebufenozide. The larvicidal activities are strongly associated with the types and patterns of substitution on the benzene, and 3,5-dimethyl, 2-nitro-4-chloro and 3-methyl derivatives are most prominent in increasing activity. Toxicity assays indicated that these derivatives could induce a premature, abnormal, and lethal larval moult. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.09.018
• 作为产物：
  描述：

  5-chlorochroman-6-carboxylic acid chloride 、 叔丁基肼盐酸盐 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以1.1 g的产率得到N'-tert-butyl-5-chlorochroman-6-carbohydrazide
  参考文献：
  名称：

  Synthesis and insecticidal evaluation of novel N′-tert-butyl-N′-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives

  摘要：

  A series of novel N'-tert-butyl- N'-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives were synthesized, and their larvicidal activities against Oriental armyworm were evaluated. The results of bioassays indicated that most of these title compounds exhibit higher larvicidal activities than RH-5849, and several of them somewhat lower than the commercial insecticide tebufenozide. The larvicidal activities are strongly associated with the types and patterns of substitution on the benzene, and 3,5-dimethyl, 2-nitro-4-chloro and 3-methyl derivatives are most prominent in increasing activity. Toxicity assays indicated that these derivatives could induce a premature, abnormal, and lethal larval moult. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.09.018