1-(naphthalen-1-yloxy)propan-2-ol | 91909-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(naphthalen-1-yloxy)propan-2-ol
• 英文别名: 1-[1]naphthyloxy-propan-2-ol；1-(1-Naphthoxy)-2-propanol；1-(1-Naphthyloxy)-2-propanol；1-naphthalen-1-yloxypropan-2-ol
• CAS: 91909-71-6
• 化学式: C₁₃H₁₄O₂
• 分子量: 202.253
• InChiKey: YJGIJBMZAQZGMM-UHFFFAOYSA-N

物化性质

• 熔点：
  64-65 °C
• 沸点：
  359.0±15.0 °C(Predicted)
• 密度：
  1.133±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(1-萘氧基)-2-丙酮 在 钾硼氢 作用下， 以 甲醇 为溶剂， 生成 1-(naphthalen-1-yloxy)propan-2-ol
  参考文献：
  名称：

  某些取代的丙酮的抗惊厥活性

  摘要：

  DOI：

  10.1021/jm00332a011

文献信息

• Heterogeneous Palladium-Catalyzed Synthesis of Aromatic Ethers by Solvent-Free Dehydrogenative Aromatization: Mechanism, Scope, and Limitations Under Aerobic and Non-Aerobic Conditions
  作者：Marc Sutter、Romain Lafon、Yann Raoul、Estelle Métay、Marc Lemaire

  DOI：10.1002/ejoc.201300485

  日期：2013.9

  derivatives and alcohols, both non-aromatic precursors, aryl ethers could be synthesized in good yields and with good selectivities in the presence of a catalytic amount of Pd/C, in one step, without added solvent, in a reaction vessel open to air. For less reactive substrates, the addition of 1-octene in a closed system under non-aerobic conditions improved the conversion. In addition, the catalyst could

  以环己酮衍生物和醇为原料，这两种非芳香族前体，芳醚可以在催化量的 Pd/C 存在下以良好的产率和良好的选择性在一个步骤中合成，无需添加溶剂，在打开的反应容器中空气。对于反应性较低的底物，在非有氧条件下在封闭系统中添加 1-辛烯可提高转化率。此外，催化剂可以循环多次使用，芳醚收率没有下降。该方法也用于四氢萘酮衍生物和多元醇。进行了几个反应以提出这种转化的机制。形成烯醇醚，然后进行脱氢反应似乎是该反应的关键步骤。
• NaOH/BEt ₃ Catalyzed Regioselective Hydroboration of Epoxides to Secondary Alcohols
  作者：Jiali Wang、Wubin Yao、Dandan Hu、Xinxin Qi、Jun‐Qi Zhang、Hongjun Ren

  DOI：10.1002/ejoc.202200759

  日期：2022.9.20

  Here described an efficient and regioselective hydroboration of epoxides to secondary alcohols, the reaction is catalyzed by a combined NaOH/BEt3 catalyst. Such a transition-metal-free catalytic system is suitable for many halogenated compounds and well-tolerated to olefin group under mild conditions.

  这里描述了环氧化物高效和区域选择性的硼氢化成仲醇，该反应由组合的 NaOH/BEt 3催化剂催化。这种不含过渡金属的催化体系适用于许多卤代化合物，并且在温和条件下对烯烃基团具有良好的耐受性。
• Dental Composite Resin Cement, Dental Primer and Dental Adhesive Kit Containing Them
  申请人：Torii Keisuke

  公开号：US20090048366A1

  公开（公告）日：2009-02-19

  The present invention provides a dental resin cement which is excellent in a mechanical strength, workability and storage stability, and a dental primer which significantly improves adhesiveness of the dental resin cement both to enamel and dentin of a tooth. According to the present invention, a salt of barbituric acid is used as a polymerization initiator in the dual-cure two-paste type dental resin cement being excellent in workability and storage stability to improve the storage stability, and a primer containing barbituric acid and amine is applied to a surface of a tooth to significantly improve adhesiveness of the dental resin cement both to enamel and dentin of teeth.

  本发明提供了一种牙科树脂水泥，具有优异的机械强度、可操作性和储存稳定性，以及一种显著改善牙科树脂水泥对牙齿釉质和牙本质的粘附性的牙科底漆。根据本发明，在双重固化两种糊状型牙科树脂水泥中，使用戊二酰脲酸盐作为聚合引发剂，以提高储存稳定性，并且在牙齿表面涂抹含有戊二酰脲酸和胺的底漆，以显著提高牙科树脂水泥对牙齿釉质和牙本质的粘附性。
• A new process for preparing novel N-(acyloxy-alkoxy) carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs
  申请人：Merck & Co., Inc.

  公开号：EP0167451A2

  公开（公告）日：1986-01-08

  This invention relates to a new one-step process for preparation of novel N-(acyloxy-alkoxy) carbonyl derivatives useful as bioreversible prodrug moieties for drugs having a primary or secondary amine function thereon.

  本发明涉及一种一步法制备新型 N-（酰氧基-烷氧基）羰基衍生物的新工艺，该衍生物可用作具有伯胺或仲胺功能的药物的生物可逆原药分子。
• Dental composition and use thereof
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10004669B2

  公开（公告）日：2018-06-26

  The invention relates to a dental composition comprising polymerizable monomer (1), initiator component(s), filler component(s) in an amount of more than about 20 wt.-%, wt.-% with respect to the whole weight of the composition, the polymerizable monomer (1) being characterized as follows: having exactly two (meth)acrylate reactive moieties, having an unsymmetrical backbone as linkage between the (meth)acrylate reactive moieties, the two (meth)acrylate reactive moieties being attached onto the unsymmetrical monomer backbone as alkyl esters, the unsymmetrical backbone comprising one aromatic moiety of the phenolic type, the polymerizable monomer (1) not containing an acidic moiety, other atoms than carbon, hydrogen, and oxygen, bisphenol moieties. The invention also relates to the use of the dental composition as or for producing a dental filling material, crown and bridge material, inlay, onlay, veneer or dental mill blank.

  本发明涉及一种牙科组合物，该组合物包含可聚合单体（1）、引发剂组分、填充剂组分，其用量占组合物总重量的 20%以上，其中可聚合单体（1）的特征如下：可聚合单体（1）的重量占组合物总重量的 20%以上，引发剂组分的重量占组合物总重量的 20%以上。可聚合单体 (1) 的特征如下：具有正好两个(甲基)丙烯酸酯活性分子，具有不对称骨架作为(甲基)丙烯酸酯活性分子之间的连接，两个(甲基)丙烯酸酯活性分子作为烷基酯连接到不对称单体骨架上，不对称骨架包括一个酚类芳香分子，可聚合单体(1)不含有酸性分子、碳、氢和氧以外的其他原子、双酚分子。本发明还涉及将牙科组合物用作或用于生产牙科填充材料、牙冠和牙桥材料、嵌体、镶嵌体、贴面或牙科磨削坯料。