5-(methylamino)-2-nitrophenol | 14703-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(methylamino)-2-nitrophenol
• 英文别名: 2-nitro 5-N-methylamino phenol；2-Hydroxy-4-methylamino-1-nitro-benzol
• CAS: 14703-78-7
• 化学式: C₇H₈N₂O₃
• 分子量: 168.152
• InChiKey: VEDQAJNCTODWDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(methylamino)-2-nitrophenol 在 platinum(IV) oxide 、 氢气 作用下， 以 甲醇 为溶剂， 反应 15.0h， 生成 2-amino-5-(methylamino)phenol
  参考文献：
  名称：

  2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

  摘要：

  2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.088
• 作为产物：
  描述：

  5-氟-2-硝基苯酚 、 盐酸甲胺 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以89%的产率得到5-(methylamino)-2-nitrophenol
  参考文献：
  名称：

  2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

  摘要：

  2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.088

文献信息

• Hair dye compositions and new compounds useful therein
  申请人：Societe Anonyme dite: L'OREAL

  公开号：US04337061A1

  公开（公告）日：1982-06-29

  Novel compounds of the general formula ##STR1## wherein Z represents a substituted lower alkyl radical; each of R.sub.1 and R.sub.2 is hydrogen atom, a lower alkyl or a substituted lower alkyl identical with or different from Z and the functional groups NO.sub.2 and NR.sub.1 R.sub.2 can occupy all ring positions in relation to OZ, with the exception that if Z is .beta.-hydroxyethyl, --NO.sub.2 is in the 4 position and --N(R.sub.1)(R.sub.2) is in the 2 position then either R.sub.1 or R.sub.2 is other than hydrogen. The novel compounds are for dyeing human hair in a variety of yellow shades. The compounds of formula (I) may be used as aqueous or water-alcohol solutions to form dye compositions for dyeing human hair.

  通用公式##STR1##中的新化合物，其中Z代表取代的较低烷基基团；R.sub.1和R.sub.2中的每一个是氢原子、较低烷基或与Z相同或不同的取代较低烷基，功能基团NO.sub.2和NR.sub.1 R.sub.2可以占据相对于OZ的所有环位置，但如果Z为β-羟乙基，则--NO.sub.2位于4位，--N(R.sub.1)(R.sub.2)位于2位，则R.sub.1或R.sub.2中的一个不是氢。这些新化合物用于染色人类头发，产生各种黄色调。公式(I)的化合物可用作水性或水醇溶液，用于制备染色人类头发的染料组合物。
• POLY(OXYALKYLENE) HYDROXY AND AMINO AROMATIC CARBAMATES AND FUEL COMPOSITIONS CONTAINING THE SAME
  申请人：Chevron Chemical Company LLC

  公开号：EP0706554B1

  公开（公告）日：2000-06-07
• POLYALKYL HYDROXY AND AMINO AROMATIC CARBAMATES AND FUEL COMPOSITIONS CONTAINING THE SAME
  申请人：CHEVRON CHEMICAL COMPANY

  公开号：EP0706551A1

  公开（公告）日：1996-04-17
• EP0706551A4
  申请人：——

  公开号：EP0706551A4

  公开（公告）日：1996-09-18
• EP0706554A4
  申请人：——

  公开号：EP0706554A4

  公开（公告）日：1996-09-18