N-tetradecylurea | 32954-73-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: N-tetradecylurea
• 英文别名: tetradecyl-urea；Tetradecyl-harnstoff；N-myristylurea；Tetradecylurea
• CAS: 32954-73-7
• 化学式: C₁₅H₃₂N₂O
• 分子量: 256.432
• InChiKey: IPOBMWQSKXACEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-tetradecylurea 在 乙醇 、 sodium 、 碳酸氢钠 作用下， 以 水 为溶剂， 反应 5.0h， 生成 sodium 5-(β-D-maltosyl)-1-tetradecylbarbiturate
  参考文献：
  名称：

  两亲性β-C-糖基巴比妥酸盐的分级自组装成多反应性海藻酸盐样超分子水凝胶纤维和囊泡水凝胶

  摘要：

  巴比妥酸介导的Knoevenagel 缩合在未受保护的碳水化合物上使两亲性 β- C-糖基巴比妥酸盐作为水凝胶剂的分子设计成为可能。单尾糖亲分子自组装成藻酸盐样多刺激触发和响应的超分子水凝胶纤维。同时，双尾糖亲分子导致了囊泡水凝胶。巴比妥酸被证明是一种高效且多功能的化学工具箱，可用于获取和设计糖缀合物。

  DOI：

  10.1002/chem.202102950
• 作为产物：
  描述：

  potassium cyanate 、 十四胺 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以91%的产率得到N-tetradecylurea
  参考文献：
  名称：

  两亲性β-C-糖基巴比妥酸盐的分级自组装成多反应性海藻酸盐样超分子水凝胶纤维和囊泡水凝胶

  摘要：

  巴比妥酸介导的Knoevenagel 缩合在未受保护的碳水化合物上使两亲性 β- C-糖基巴比妥酸盐作为水凝胶剂的分子设计成为可能。单尾糖亲分子自组装成藻酸盐样多刺激触发和响应的超分子水凝胶纤维。同时，双尾糖亲分子导致了囊泡水凝胶。巴比妥酸被证明是一种高效且多功能的化学工具箱，可用于获取和设计糖缀合物。

  DOI：

  10.1002/chem.202102950

文献信息

• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Shinohata Masaaki

  公开号：US20110133121A1

  公开（公告）日：2011-06-09

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明涉及一种从有机胺、碳酸衍生物和含有一种或多种羟基化合物中制得的N-取代氨基甲酸酯的制备方法，其中使用一种含有冷凝器的脲类生产反应容器反应有机胺、碳酸衍生物和羟基化合物，将含有羟基化合物的气体、来自碳酸衍生物衍生的含有羰基基团的化合物、以及在反应中形成的氨气体引入到脲类生产反应容器中的冷凝器中，使羟基化合物和含有羰基基团的化合物冷凝，其中在冷凝的羟基化合物中所含有的羟基化合物与冷凝的含有羰基基团的化合物中所含有的羰基基团的化合物的比例为1或更多，而且在从冷凝器中回收的氨气体中所含有的羰基基团（—C(═O)—）数与氨分子数的比例为1或更少。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, and Composition for Transfer and Storage of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Asahi Kasei Chemicals Corporation

  公开号：US20140194650A1

  公开（公告）日：2014-07-10

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种从有机胺、碳酸酯衍生物和含有一种或多种羟基化合物中制备N-取代的氨基甲酸酯的方法，其中利用一种尿素生产反应容器反应有机胺、碳酸酯衍生物和羟基化合物，该反应容器配有冷凝器，将含有羟基化合物的气体、由碳酸酯衍生物产生的含有羰基基团的化合物以及在反应中生成的氨引入到尿素生产反应容器中的冷凝器中，将羟基化合物和含有羰基基团的碳酸酯衍生物冷凝，其中在冷凝的羟基化合物中所含的羟基化合物的化学计量比与所冷凝的含有羰基基团的化合物的化学计量比为1或更多，而且所含有羰基基团的化合物中所含的羰基基团（-C(═O)-）的数量与从冷凝器中回收的氨分子数量的比率为1或更小。
• INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA
  申请人：Ammendola Aldo

  公开号：US20090192192A1

  公开（公告）日：2009-07-30

  The present invention relates to the use of compounds as broad spectrum inhibitors of bacterial biofilm formation. In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative and Gram-positive bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of bacterial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.

  本发明涉及使用化合物作为广谱细菌生物膜形成的抑制剂。具体而言，本发明涉及一系列化合物，能够阻断革兰氏阴性和革兰氏阳性细菌的群体感应系统，一种制造它们的方法，含有它们的制药组合物以及它们用于治疗和预防细菌损害和疾病的用途，特别是对于需要抑制病原体的群体感应调节表型的疾病有优势的情况。
• LUBRICATING OIL ADDITIVE AND LUBRICATING OIL COMPOSITION
  申请人：Nippon Oil Corporation

  公开号：EP1686167A1

  公开（公告）日：2006-08-02

  Lubricating oil compositions have low friction properties and anti-wear properties and are excellent in long drain capability. The lubricating oil compositions are particularly suitable for use as a fuel efficient type lubricating oil for internal combustion engines. The lubricating oil compositions contain a lubricating oil additive comprising one or more compounds selected from a specific nitrogen-containing compound, an acid-modified derivative thereof, and an oil soluble metal complex obtained by mixing the nitrogen-containing compound and/or acid-modified derivative thereof with an organic metal salt and/or organic metal complex.

  润滑油组合物具有低摩擦特性和抗磨损特性，并且具有出色的长换油期能力。润滑油组合物特别适合用作内燃机的节油型润滑油。润滑油组合物含有一种润滑油添加剂，该添加剂由一种或多种化合物组成，这些化合物选自特定的含氮化合物、其酸性改性衍生物以及通过将含氮化合物和/或其酸性改性衍生物与有机金属盐和/或有机金属复合物混合而获得的油溶性金属复合物。
• LOW-ASH ENGINE OIL COMPOSITION
  申请人：Nippon Oil Corporation

  公开号：EP1997871A1

  公开（公告）日：2008-12-03

  The present invention provides a low ash engine oil composition which, despite the low ash content, has engine detergency which enables the composition to pass severe detergency tests for diesel engine oils. The engine oil composition contains 0.6 percent by mass or less of a sulfated ash and comprises a low ash engine oil composition with a sulfated ash content of 0.6 percent by mass or less, which comprises: a lubricating base oil with a %CA of 2 or less, a kinematic viscosity at 40°C of 25 mm2/s or less and a viscosity index of 120 or greater; a viscosity index improver contained in such an amount that the viscosity index of the composition will be 160 or greater; (A) a metallic detergent with a metal ratio of 3 or less; and/or (B) a sulfur-free phosphorus compound.

  本发明提供了一种低灰分发动机油组合物，尽管灰分含量低，但其发动机清净性却能使该组合物通过柴油发动机油的严酷清净性测试。该发动机油组合物含有 0.6% 或更低质量的硫酸盐灰分，包括硫酸盐灰分含量为 0.6% （以质量计）或更低的低灰份发动机油组合物，其中包括：润滑基础油，其 %CA 为 2 或更低，40°C 时的运动粘度为 25 mm2/s 或更低，粘度指数为 120 或更高；粘度指数改进剂，其含量应使组合物的粘度指数为 160 或更高；(A) 金属比为 3 或更低的金属清净剂；和/或 (B) 无硫磷化合物。