1-(3-甲氧基苯基)哌啶 | 32040-06-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(3-甲氧基苯基)哌啶
• 英文名称: N-(3-methoxyphenyl)piperidine
• 英文别名: 1-(3-methoxyphenyl)piperidine
• CAS: 32040-06-5
• 化学式: C₁₂H₁₇NO
• mdl: MFCD00094104
• 分子量: 191.273
• InChiKey: GZGYOLIWTUXMAR-UHFFFAOYSA-N

物化性质

• 沸点：
  110 °C(Press: 0.2 Torr)
• 密度：
  1.059 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

SDS

1-(3-Methoxyphenyl)piperidineMSDS英文版

反应信息

• 作为反应物：
  描述：

  1-(3-甲氧基苯基)哌啶 在 氢溴酸 作用下， 生成 3-哌啶基苯酚
  参考文献：
  名称：

  The Reaction of 1,5-Dibromopentane with o-Substituted Anilines. The Synthesis of 1-Arylpiperidines¹

  摘要：

  DOI：

  10.1021/ja01117a041
• 作为产物：
  描述：

  1,5-二氯戊烷 在 sodium hydride 作用下， 以 四氢呋喃 、 甲苯 、 mineral oil 为溶剂， 反应 48.17h， 生成 1-(3-甲氧基苯基)哌啶
  参考文献：
  名称：

  [EN] NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
  [FR] FORMULATIONS DE FLUOROPHORE SPÉCIFIQUE AUX NERFS POUR ADMINISTRATION DIRECTE ET SYSTÉMIQUE

  摘要：

  描述了用于直接或全身给药的神经特异性荧光素配方。这些配方可用于荧光引导手术（FGS），帮助在外科手术干预期间保护神经。

  公开号：

  WO2020033435A1

文献信息

• Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation
  申请人：Iowa State University Research Foundation, Inc.

  公开号：US07385058B1

  公开（公告）日：2008-06-10

  Methods and compounds are provided for the formation of carbon-nitrogen or carbon-carbon bonds comprising reacting an amine or an aryl boronic acid with an aryl halide in the presence of a palladium catalyst, a base, and a compound of formula II:

  方法和化合物用于形成碳氮或碳碳键，包括在钯催化剂、碱和公式II化合物的存在下，将胺或芳基硼酸与芳基卤化物反应。
• Synthesis and characterization of N-heterocyclic carbene-palladium(<scp>ii</scp>) chlorides-1-methylindazole and -1-methylpyrazole complexes and their catalytic activity toward C–N coupling of aryl chlorides
  作者：Xiao-Yun Zhao、Quan Zhou、Jian-Mei Lu

  DOI：10.1039/c6ra02556k

  日期：——

  series of N-heterocyclic carbene-palladium(II) chlorides-1-methylindazole and -1-methylpyrazole complexes was successfully synthesized and fully characterized by X-ray single crystal diffraction. In addition, initial investigations of their catalytic activity showed that they were efficient catalysts in the C–N coupling of primary and secondary amines with aryl chlorides at low catalyst loadings.

  成功合成了一系列N-杂环卡宾-钯（II）氯化物-1-甲基吲唑和-1-甲基吡唑配合物，并通过X射线单晶衍射对其进行了全面表征。此外，对其催化活性的初步研究表明，它们在低催化剂负载量下，伯胺和仲胺与芳基氯的C-N偶联反应中是有效的催化剂。
• Platinum/Scandium-Cocatalyzed Cascade Cyclization and Ring-Opening Reaction of Tertiary Amines with Substituted Salicylaldehydes to Synthesize 3-(Aminoalkyl)coumarins
  作者：Xiao-Feng Xia、Xing-Zhong Shu、Ke-Gong Ji、Ali Shaukat、Xue-Yuan Liu、Yong-Min Liang

  DOI：10.1021/jo102219z

  日期：2011.1.7

  oxidative dehydrogenation of α,β-C(sp3)−H bonds of tertiary amines in the presence of ambient oxygen followed by reactions with substituted salicylaldehydes is revealed. The in situ formed enamines reacted with various salicylaldehydes, which resulted in the development of a one-pot synthetic protocol involving aldol reaction, cyclization, and then ring-opening.

  揭示了3-（氨基烷基）香豆素的合成，其在环境氧存在下由叔胺的α，β-C（sp 3）-H键经铂/ scan共催化氧化脱氢，然后与取代的水杨醛反应。原位形成的烯胺与各种水杨醛反应，从而导致了涉及一羟醛反应，环化和开环的一锅合成方案的发展。
• Solvent-Regulated Coupling of 2-Alkynylbenzaldehydes with Cyclic Amines: Selective Synthesis of Fused N-Heterocycles and Functionalized Naphthalene Derivatives
  作者：Yan He、Zhi Zheng、Qimeng Liu、Xinying Zhang、Xuesen Fan

  DOI：10.1021/acs.orglett.0c03442

  日期：2020.11.20

  synthesis of 1,2,3,4-tetrahydrobenzo[g]quinoline derivatives through PdCl2-catalyzed, TBHP-promoted, and toluene-mediated dehydrogenation/[4+2] cycloaddition of saturated cyclic amines with 2-alkynylbenzaldehydes was developed. On the contrary, when the reaction medium was changed from toluene to DMSO/H2O, another class of important compounds, naphthyl chain amines, formed via a dehydrogenation–intermolecular

  通过PdCl 2催化，TBHP促进和甲苯介导的饱和环胺的脱氢/ [4 + 2]与2-炔基苯甲醛的环加成反应，成功合成了1,2,3,4-四氢苯并[ g ]喹啉衍生物。相反，当反应介质从甲苯变为DMSO / H 2 O时，通过脱氢-分子间缩合-C-N键裂解-分子间缩合途径形成的另一类重要化合物萘链胺选择性好。
• Selective Cleavage and Tunable Functionalization of the C–C/C–N Bonds of <i>N</i>-Arylpiperidines Promoted by ^<i>t</i>BuONO
  作者：Yan He、Zhi Zheng、Yajie Liu、Jiajie Qiao、Xinying Zhang、Xuesen Fan

  DOI：10.1021/acs.orglett.9b00226

  日期：2019.3.15

  In this paper, selective cleavage and tunable functionalization of the inert C–C/C–N bonds in N-arylpiperidines promoted by tBuONO under metal-free conditions is presented. To be specific, when the reaction was run in acetonitrile in the presence of molecular sieves, the synthetically useful acyclic N-formyl nitriles are formed. On the other hand, when alcohol was used as the reaction medium, the corresponding

  本文提出了在无金属条件下t BuONO促进的N-芳基哌啶中惰性CC -C / C-N键的选择性裂解和可调功能。具体而言，当反应在分子筛存在下在乙腈中进行时，形成了合成上有用的无环N-甲酰基腈。另一方面，当使用醇作为反应介质时，相应的反应通过机理上不同的途径提供了N-亚硝基链酯作为主要产物。