2,4,6-三氯-3-硝基苯酚 | 100130-16-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2,4,6-三氯-3-硝基苯酚
• 英文名称: 3-nitro-2,4,6-trichlorophenol
• 英文别名: 2,4,6-trichloro-3-nitrophenol；2.4.6-Trichlor-3-nitro-1-hydroxy-benzol；2,4,6-Trichlor-3-nitro-phenol；2,4,6-Trichloro-3-nitrophenol
• CAS: 100130-16-3
• 化学式: C₆H₂Cl₃NO₃
• 分子量: 242.446
• InChiKey: BGFQCTRASCWDAW-UHFFFAOYSA-N

物化性质

• 沸点：
  317.8±42.0 °C(Predicted)
• 密度：
  1.788±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4,6-三氯-3-硝基苯酚 在 盐酸 、 tin 作用下， 生成 2,4,6-Trichlor-3-aminophenol
  参考文献：
  名称：

  Daccomo, Chemische Berichte, 1885, vol. 18, p. 1168

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4,6-三氯苯酚 在 五氧化二氮 作用下， 以 various solvent(s) 为溶剂， 生成 2,4,6-三氯-3-硝基苯酚
  参考文献：
  名称：

  Crampton; Gibbons; Millar, Journal of the Chemical Society. Perkin Transactions 2 (2001), 2001, # 9, p. 1662 - 1665

  摘要：

  DOI：

文献信息

• A Facile Procedure for Halodecarboxylation of Hydroxyaromatic Carboxylic Acids
  作者：Zhenbei Zhang、Olha Bakumenko、Feng Xue、Wenhui Sun、Zhishan Cao、Guisheng Zhang

  DOI：10.1055/a-2294-4029

  日期：——

  An efficient approach is reported for the direct halodecarboxylation of hydroxyaromatic acids by using a readily available N-halosuccinimide (halo = Cl, Br) as the sole promoter in ethanol at room temperature without any other catalyst or additive. This environmentally friendly route tolerates a wide substrate scope with good to excellent yields under convenient conditions.

  据报道，一种有效的方法是在室温下使用容易获得的N -卤代琥珀酰亚胺（卤素 = Cl、Br）作为乙醇中的唯一促进剂，在没有任何其他催化剂或添加剂的情况下，直接进行羟基芳香酸的卤代脱羧。这种环境友好的路线可耐受较宽的底物范围，在便利的条件下具有良好至优异的产量。
• RAPD- and<i>actA</i>Gene-Typing of<i>Listeria monocytogenes</i>Isolates of Human Listeriosis, the Intestinal Contents of Cows and Beef
  作者：Satoshi Inoue、Kazuhiro Katagiri、Michinori Terao、Tsutomu Maruyama

  DOI：10.1111/j.1348-0421.2001.tb01280.x

  日期：2001.2

  AbstractSeventy‐five L. monocytogenes isolates of human listeriosis, the intestinal contents of cows and beef were divided into 5 major clusters, 17 sub‐clusters and 28 minor clusters by typing using random amplification of polymorphic DNA (RAPD). According to their major RAPD category, L. monocytogenes isolates serotyped as 1/2b and 4b were distinguished from L. monocytogenes isolates of serovars 1/2a and 1/2c. Moreover serovar 4b was distinguished from serovar 1/2b by a difference in the RAPD sub‐cluster category. All L. monocytogenes were found to possess either actA gene Type I or n, and only one actA gene type was detected in each RAPD minor cluster. actA gene Type II was observed in 32.0%, 38.5 % and 18.9% of isolates from humans, cows and beef, respectively, and was detected more frequently in serovar 4b (46.9%) than in serovars 1/2a (22.2%), 1/2b (7.7%) and 1/2c (0.0%). Twenty (80%) of 25 human isolates fell within three minor RAPD types (II‐d (16%), V‐p‐1 (36%), V‐p‐2 (28%)). Two isolates from humans and beef were found to have the same RAPD type (Type IV‐k‐1), actA gene type (Type I) and serovar (1/2b). Our results suggest that only a few genotypes of L. monocytogenes are predominant in human listeriosis in Japan, although the human isolates were collected over a broad span of time and a wide geographical range. Our results also suggest that RAPD‐, actA gene‐ and sero‐typing can be useful for epidemiological analysis.
• CCXL.—The scission of diaryl ethers and related compounds by means of piperidine. Part V. The nitration of methyl-, dimethyl-, and polyhalogeno-derivatives of diphenyl ether
  作者：Dorothy Lilian Fox、Eustace Ebenezer Turner

  DOI：10.1039/jr9300001853

  日期：——
• Crampton; Gibbons; Millar, Journal of the Chemical Society. Perkin Transactions 2 (2001), 2001, # 9, p. 1662 - 1665
  作者：Crampton、Gibbons、Millar

  DOI：——

  日期：——
• Daccomo, Chemische Berichte, 1885, vol. 18, p. 1168
  作者：Daccomo

  DOI：——

  日期：——