ethyl chlorodithioformate | 35447-70-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫基化合物
• 英文名称: ethyl chlorodithioformate
• 英文别名: dithiocarbonochloridic acid ethyl ester；chlorodithiocarbonic acid ethyl ester；Chlorodithiokohlensaeure-aethylester；Dithiokohlensaeure-S-aethylester-chlorid；Chlordithioameisensaeure-aethylester；ethyl chlorodithiocarbonate；ethyl chloromethanedithioate
• CAS: 35447-70-2
• 化学式: C₃H₅ClS₂
• 分子量: 140.658
• InChiKey: KXONJIYGYMNJHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl chlorodithioformate 以 甲醇 为溶剂， 反应 2.0h， 以50%的产率得到O-Methyl S-Ethyl Dithiocarbonate
  参考文献：
  名称：

  A general strategy for elaboration of the dithiocarbonyl functionality, -(C:O)SS-: application to the synthesis of bis(chlorocarbonyl)disulfane and related derivatives of thiocarbonic acids

  摘要：

  DOI：

  10.1021/jo00172a056
• 作为产物：
  描述：

  硫光气 生成 ethyl chlorodithioformate
  参考文献：
  名称：

  Houben; Schultze, Chemische Berichte, 1911, vol. 44, p. 3239

  摘要：

  DOI：

文献信息

• A Facile Synthesis of Trifluoromethylamines by Oxidative Desulfurization–Fluorination of Dithiocarbamates
  作者：Kiyoshi Kanie、Katsuya Mizuno、Manabu Kuroboshi、Tamejiro Hiyama

  DOI：10.1246/bcsj.71.1973

  日期：1998.8

  conditions. When this reaction was applied to dithiocarbamates ArN(R)CS2Me at higher temperatures, the trifluoromethylation was accompanied by halogen substitution at the p-position of the Ar group. The synthesis of trifluoromethyl-substituted adenosine is also described.

  三氟甲胺很容易从二硫代氨基甲酸酯通过由四丁基二氢三氟化铵和 N-卤代酰亚胺组成的试剂系统在温和条件下合成。当该反应在较高温度下应用于二硫代氨基甲酸酯 ArN(R)CS2Me 时，三氟甲基化伴随着 Ar 基团对位的卤素取代。还描述了三氟甲基取代的腺苷的合成。
• [EN] INTERMEDIATE AND PROCESSES INVOLVED IN THE PREPARATION OF 2 ' -CYANO-2 ' -DE0XY-N4-PALMIT0YL-1-BETA-ARABIN0FURAN0SYLCYTOSINE<br/>[FR] INTERMÉDIAIRE ET PROCÉDÉS ASSOCIÉS À LA PRÉPARATION DE 2'-CYANO-2'-DÉSOXY-N4-PALMITOYL-1-BÊTA-ARABINOFURANOSYLCYTOSINE
  申请人：CYCLACEL LTD

  公开号：WO2009136162A1

  公开（公告）日：2009-11-12

  The present invention relates to a process for preparing a compound of formula (682-6'), said process comprising the steps of: formula (682-4), (682-5), (682-6'): (i) converting a compound of formula (682-4) into a compound of formula (682-5); and (ii) converting said compound of formula (682-5) into a compound of formula (682- 6'). Further aspects of the invention relate to the use of the above process in the preparation of 2'-cyano-2'-deoxy-N4-palmitoyl-l-β-D-arabinofuranosylcytosine, a pyrimidine nucleoside which is therapeutically useful in the treatment and/or prevention of cancer.

  本发明涉及一种制备式（682-6'）化合物的方法，该方法包括以下步骤：式（682-4）、（682-5）、（682-6'）：（i）将式（682-4）化合物转化为式（682-5）化合物；以及（ii）将所述式（682-5）化合物转化为式（682-6'）化合物。该发明的进一步方面涉及上述方法在制备2'-氰基-2'-脱氧-N4-棕榈酰-1-β-D-阿拉伯呋喃核苷胞嘧啶中的应用，该核苷是治疗和/或预防癌症中具有治疗作用的。
• A convenient one-step procedure for the synthesis of ketene O,S- and ketene S,S-acetals via thioacylation of malononitrile
  作者：N.H. Nilsson

  DOI：10.1016/s0040-4020(01)97571-4

  日期：1974.1

  (XO) in the presence of two equivalents of sodium hydride followed by alkylation of the intermediate thiolate anion 3. In a similar manner a number of unsymmetrical ketene S,S-acetals were synthesised via thioacylation of 1 with chlorodithioformate esters 2 (XS). The reaction of the ketene O,S-acetals with secondary amines was investigated.

  通过在两个当量的氢化钠存在下将丙二腈1与氯代硫代甲酸酯2（X = O）缩合，然后将中间体硫醇盐阴离子3烷基化，制备了酮O，S-乙缩醛。以类似的方式，通过1与氯二硫代甲酸酯2（X = S）的硫酰化反应，合成了许多不对称的乙烯酮S，S-缩醛。研究了烯酮O，S-缩醛与仲胺的反应。
• New Heterocyclic Precursors for Thermal Generation of Reactive, Electron-Rich 1,2-Diaza-1,3-butadienes
  作者：Robert K. Boeckman,、Ping Ge、Jessica E. Reed

  DOI：10.1021/ol0165645

  日期：2001.11.1

  [reaction--see text] [corrected] The preparation and thermolysis of new stable heterocyclic precursors of 1,2-diaza-1,3-butadienes is described. The resulting reactive diazadienes are trapped in situ with N-phenylmaleimide [corrected]. The effect of precursor structure on the temperature at which the diazadienes are generated is discussed.

  [反应-见正文] [已更正]描述了1,2-二氮杂-1,3-丁二烯新的稳定杂环前体的制备和热解。生成的反应性二氮杂二烯被N-苯基马来酰亚胺原位捕获[校正]。讨论了前体结构对生成二氮杂二烯的温度的影响。
• Acrylonitrile compounds, process for their production and pesticides containing them
  申请人：Ishihara Sangyo Kaisha Ltd.

  公开号：US06187944B1

  公开（公告）日：2001-02-13

  Acrylonitrile compounds having pesticidal activity of formula (I) and salts thereof. wherein Q is Y is ═C(R4)— or ═N—, R1 is alkyl, haloalkyl, etc., each of R2 and R3 is halogen, alkyl which may be substituted, alkenyl which may be substituted, etc., R4 is hydrogen, halogen, alkyl or haloalkyl, 1 is from 1 to 4, m is from 0 to 5, n is from 0 to 3, q is from 0 to 4, when 1 is 2 or more, a plurality of R2 may be the same or different, when each of m, n and q is 2 or more, a plurality of R3 may be the same or different.

  具有杀虫活性的丙烯腈化合物的化学式（I）及其盐。其中Q是Y是═C(R4)—或═N—，R1是烷基，卤代烷基等，R2和R3中的每一个是卤素，可能被取代的烷基，可能被取代的烯基等，R4是氢，卤素，烷基或卤代烷基，1为1至4，m为0至5，n为0至3，q为0至4，当1为2或更多时，多个R2可能相同或不同，当m、n和q中的每一个为2或更多时，多个R3可能相同或不同。