N-Sulfamoyl-N'-phenylpiperazin | 29609-33-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-Sulfamoyl-N'-phenylpiperazin
• 英文别名: 4-phenyl-piperazine-1-sulfonic acid amide；4-Phenylpiperazine-1-sulfonamide
• CAS: 29609-33-4
• 化学式: C₁₀H₁₅N₃O₂S
• mdl: MFCD11205192
• 分子量: 241.314
• InChiKey: PGOWYQPWIHCLJF-UHFFFAOYSA-N

物化性质

• 沸点：
  431.2±55.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  75
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-Sulfamoyl-N'-phenylpiperazin 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 N-sulfamoyl-N'-phenylpiperazine hydrochloride
  参考文献：
  名称：

  Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions

  摘要：

  本发明涉及利用已知和新颖的对应于式I的N-磺酰基-N'-芳基哌嗪及其生理兼容性酸盐，用于治疗或抑制肥胖及相关疾病的用途。

  公开号：

  US20050261292A1
• 作为产物：
  描述：

  N-苯基哌嗪 在 磺酰胺 作用下， 以 甲苯 为溶剂， 生成 N-Sulfamoyl-N'-phenylpiperazin
  参考文献：
  名称：

  Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions

  摘要：

  本发明涉及利用已知和新颖的对应于式I的N-磺酰基-N'-芳基哌嗪及其生理兼容性酸盐，用于治疗或抑制肥胖及相关疾病的用途。

  公开号：

  US20050261292A1

文献信息

• Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard
  作者：H. Cheloufi、B. Belhani、T. S. Ouk、R. Zerrouki、N.-E. Aouf、M. Berredjem

  DOI：10.1007/s11030-015-9647-6

  日期：2016.5

  A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a–m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported

  合成了一系列新的磺酰基环脲衍生物，并在体外评估了它们对四种癌细胞系（A431，Jurkat，U266和K562）的抗肿瘤活性。这些化合物是通过几种磺酰胺（2a–m）与双（2-氯乙基）氨基甲酸乙酯（1a）缩合制备的。据报道这些新衍生物与苯丁酸氮芥相比具有相对的细胞毒性。
• An Eco-friendly and Highly Efficient route for N-acylation under Catalyst-free Conditions
  作者：Souad Ouarna、Hacène K’tir、Salah Lakrout、Hamida Ghorab、Aïcha Amira、Zineb Aouf、Malika Berredjem、Nour Aouf

  DOI：10.13005/ojc/310235

  日期：2015.6.20

  An eco-friendly, simple, mild, chemo selective and highly efficient procedure for the acylation of primary and secondary amine function in various structurally and electronically aliphatic and aromatic compounds affording their corresponding N-Ac derivatives is developed. Mild conditions, simplicity and easier work-up are the main advantages of this method.

  开发了一种环保、简单、温和、化学选择性高且高效的方法，用于各种结构和电子性质的脂肪族和芳香族化合物中的伯胺和仲胺官能团的酰化反应，生成相应的N-酰基衍生物。温和条件、简单操作及易于后处理是该方法的主要优点。
• N-Sulfamoyl-piperidineamides for the treatment or inhibition of obesity and related conditions
  申请人：Antel Jochen

  公开号：US20070149512A1

  公开（公告）日：2007-06-28

  The present invention relates to novel N-sulfamoyl-piperidineamides of Formula I and their physiologically acceptable acid addition salts, to pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment of obesity and its concomitant and/or secondary diseases and related or other conditions.

  本发明涉及具有化学式I的新型N-磺胺基哌啶酰胺及其生理上可接受的酸盐，包括含有它们的药物组合物，其制备方法，以及用于治疗肥胖及其伴随和/或继发疾病以及相关或其他病症的用途。
• Simple, rapid, and clean condensation of sulfonamide and maleic anhydride derivatives: Synthesis of novel 1<i>H</i>- Pyrrole-2,5-diones under heterogeneous conditions
  作者：Chafika Bougheloum、Samia Guezane Lakoud、Robila Belghiche、Abdelrani Messalhi

  DOI：10.1080/10426507.2016.1193504

  日期：2016.10.2

  GRAPHICAL ABSTRACT ABSTRACT H6P2W18O62 is used as an efficient catalyst for the synthesis of novel N-substituted sulfonyl maleimides (1H-Pyrrole-2,5-diones) via the condensation of sulfonamide and maleic anhydride derivatives. The Dawson heteropolyacid was used with a catalytic amount of 2 mmol% in acetonitrile at reflux. The reuse of H6P2W18O62 as heterogeneous catalyst several times without decrease

  图形摘要 摘要 H6P2W18O62 可用作通过磺酰胺和马来酸酐衍生物缩合合成新型 N-取代磺酰基马来酰亚胺（1H-吡咯-2,5-二酮）的有效催化剂。Dawson 杂多酸在回流下以在乙腈中的催化量为 2 mmol% 使用。H6P2W18O62 作为多相催化剂多次重复使用而不会降低其活性、反应时间短、易于分离所需产物且产率良好至极好显示了这种新方法的优点。
• Efficient<i>N</i>-acylation of sulfonamides using cesium salt of Wells–Dawson heteropolyacid as catalyst: Synthesis of new<i>N</i>-acyl sulfonamides and cyclic imides
  作者：Nesma Benali、Chafika Bougheloum、Sabrina Alioua、Robila Belghiche、Abdelrani Messalhi

  DOI：10.1080/00397911.2018.1535077

  日期：2018.12.17

  Abstract N-acylation of substituted sulfonamides with different anhydrides in the presence of Cesium salt of Wells–Dawson heteropolyacid (Cs5HP2W18O62) as an efficient and reusable catalyst was investigated for the first time. Cs5HP2W18O62 was used with a catalytic amount in water as a green solvent. At room temperature, a series of N-acylsulfonamides were synthesized, while under refluxing conditions

  摘要 首次研究了在 Wells-Dawson 杂多酸铯盐 (Cs5HP2W18O62) 存在下，取代磺酰胺与不同酸酐的 N-酰化反应，该催化剂是一种高效且可重复使用的催化剂。Cs5HP2W18O62 以催化量在水中用作绿色溶剂。在室温下合成了一系列N-酰基磺酰胺，在回流条件下得到了新的含有磺酰基的环状酰亚胺。原子经济性、高产率、易于后处理以及简单的催化剂回收和可重复使用是该过程的关键特征。图形摘要