1-氯-3-(2-苯基乙基)苯 | 34176-92-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1-氯-3-(2-苯基乙基)苯
• 英文名称: 1-chloro-3-phenethylbenzene
• 英文别名: 3-chloro-bibenzyl；4-Chlor-1,2-diphenylethan；1-m-Chlorphenyl-2-phenylaethan；3-Chlor-dibenzyl；3-Chlor-bibenzyl；1-Chloro-3-(2-phenylethyl)benzene
• CAS: 34176-92-6
• 化学式: C₁₄H₁₃Cl
• 分子量: 216.71
• InChiKey: NWVGKFZMBBPAJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903999090

反应信息

• 作为反应物：
  描述：

  4-乙烯基联苯 、 1-氯-3-(2-苯基乙基)苯 在 2,4,5-tri(9H-carbazol-9-yl)-6-(ethyl(phenyl)amino)isophthalonitrile 、 caesium carbonate 、 N,N-二异丙基乙胺 作用下， 以 水 、 乙腈 为溶剂， 以54 %的产率得到4-(3-phenethylphenethyl)-1,1'-biphenyl
  参考文献：
  名称：

  通过连续光致电子转移进行烯烃与芳基氯的无过渡金属反马尔可夫尼科夫氢芳基化

  摘要：

  烯烃的氢芳基化已成为芳烃官能化的强大策略。然而，由于C(sp 2 )–Cl键的化学惰性和高负还原电位，芳基氯在此类反应中仍然是一个巨大的挑战。在此，我们报道了通过可见光光氧化还原催化烯烃与芳基氯化物的反马尔可夫尼科夫自由基氢芳基化。通过连续的光诱导电子转移，可以从芳基氯中有效地获得关键的反应性芳基自由基。这种不含过渡金属的方案具有条件温和、底物范围广和官能团耐受性的特点，能够以中等至良好的收率产生多种线性烷基芳烃。建议该反应通过自由基-极性交叉途径进行。

  DOI：

  10.1021/acs.orglett.4c00106
• 作为产物：
  描述：

  (E)-3-chlorostilbene 在 乙醇 、 镍 作用下， 生成 1-氯-3-(2-苯基乙基)苯
  参考文献：
  名称：

  Alcohol Drinkers Overreport Their Energy Intake in the BIRNH Study: Evaluation by 24-Hour Urinary Excretion of Cations

  摘要：

  Objective: Alcohol drinkers are generally considered to underreport their alcohol intake, but little is known about whether they correctly report their energy intake (EI). We assessed the validity of the reported energy intake of alcohol drinkers using the 24-hour urinary (U) excretion of potassium (K) and sodium (Na) as biomarkers.Methods: A total of 2,124 men and 1,998 women 25 to 74 years of age with a 24-hour urine collection. a random sample of the Belgian Interuniversity Research on Nutrition and Health (BIRNH), were studied. Dietary intake (D), including alcohol consumption, was assessed by a one-day food record, Basal metabolic rate (BMR) was predicted from age gender and weight. As a measure for the degree of reporting error. D-K/U-K, D-Na/U-Na, EI/U-K, Non-alcohol EI/U-Na (NAEI/U-Na), Ei/U-Na, EVU-creatinine and EI/BMR ratios were calculated and compared among non-, moderate and heavy drinkers in both genders.Results: El, NAEI and all seven ratios examined generally increased with the level of alcohol intake in both genders. After adjustment for age, body mass index, smoking and educational level, most ratios were significantly higher in moderate drinkers (p < 0.02 to p < 0.0001) and in heavy drinkers (all p < 0.0001) than in non-drinkers. These differences were most significant in male heavy drinkers. The exceptions were D-K/U-K. D-Na/U-Na and NAEI/U-Na in moderate and female heavy drinkers and EI/U-K in male moderate drinkers. The estimated amount of the overreporting of El by heavy drinkers was 27.8% in men and 13.7% in women.Conclusions: This study provides evidence that El and NAEI obtained from the BIRNH study was overreported among alcohol drinkers, especially among male heavy drinkers. It also indicates that El from alcohol replaced El from food.

  DOI：

  10.1080/07315724.2001.10719060

文献信息

• Friedel-Crafts Aralkylation. II. The AlCl₃·CH₃NO₂-catalyzed Phenethylation of Benzene and Toluene with 2-Arylethyl Chlorides in a Nitromethane Solution
  作者：Makoto Ichii

  DOI：10.1246/bcsj.45.2810

  日期：1972.9

  attack by the aromatic substrate on the phenethyl chloride-catalyst system is proposed for the reactions. Competitive phenethylations of benzene and toluene were also carried out at 50°C. Both the isomer distribution and the relative reactivity of toluene to benzene are affected by the ring-substituents, the effects of which are correlated closer with the substrate selectivity. These results suggest

  在均相硝基甲烷溶液中测量 AlCl3·CH3NO2 催化苯（50°C）或甲苯（25°C）与 2-芳基乙基（环取代的苯乙基）氯化物的苯乙基化反应的速率。芳烃组分为一级反应，苯乙基氯为一级反应，氯化铝为二级反应。苯乙基氯中的取代基效应与哈米特的 σ 常数呈线性关系。提出了一种置换机制，包括芳族底物对苯乙基氯-催化剂体系的亲核攻击。苯和甲苯的竞争性苯乙基化也在 50°C 下进行。异构体分布和甲苯对苯的相对反应性都受环取代基的影响，其影响与底物选择性更密切相关。这些结果表明，苯乙基化速率决定步骤中的过渡态本质上是（定向的）π 复合物，而不是 σ co...
• General and selective homogeneous Ru-catalyzed transfer hydrogenation, deuteration, and methylation of functional compounds using methanol
  作者：Murugan Subaramanian、Ganesan Sivakumar、Vinod G. Landge、Rohit Kumar、Kishore Natte、Rajenahally V. Jagadeesh、Ekambaram Balaraman

  DOI：10.1016/j.jcat.2023.06.035

  日期：2023.9

  pharmaceuticals such as d-Cloperastine, d-Buclizine, d-Diphendyarmine, d-Modafinil, and d-Adrafinil using CD3OD. In addition, the application of methanol as a C1 source for the preparation of N-methylated products is showcased. Finally, kinetic and mechanistic investigations for this Ru-catalyzed transfer hydrogenation and deuteration protocols have been performed.

  有机合成和能源技术中甲醇的催化增值对于基础研究和工业应用来说都是有趣且重要的。特别是，它作为氢、氘和甲基源用于选择性还原和氘化反应以及获得N-甲基化产物是非常理想的，并且可以被认为是放大转移氢化和C1化学的潜在方法。在这里，我们报道了均相 Ru-MACHO 配合物催化不同官能化化合物（如酮、醛、炔烃、烯烃、亚胺、偶氮苯和硝基化合物）的转移氢化以及N的脱氧使用甲醇作为负担得起的氢供体和溶剂的氧化物衍生物。这种基于钌的策略已被证明对于合成先进氘标记化合物的氘化过程非常方便，包括克级合成氘代药物，如d-氯哌斯汀、d-布克利嗪、d-苯地亚明、d-莫达非尼和d -Adrafinil 使用 CD 3 OD。此外，还展示了甲醇作为C1源用于制备N-甲基化产物的应用。最后，对这种钌催化的转移氢化和氘化方案进行了动力学和机理研究。
• Organic electroluminescent materials and devices
  申请人：Universal Display Corporation

  公开号：US10941170B2

  公开（公告）日：2021-03-09

  The present invention includes novel hexadentate metal complexes. The complexes hexadentate ligands of the present invention may be useful as improved emitters in an OLED device.

  本发明包括新型六价金属配合物。本发明的六价配体络合物可用作 OLED 设备中的改进型发光体。
• Chemistry of the tert-butyl radical: polar character, .rho. value for reaction with toluenes, and the effect of radical polarity on the ratio of benzylic hydrogen abstraction to addition to aromatic rings
  作者：William A. Pryor、Felicia Y. Tang、Robert H. Tang、Daniel F. Church

  DOI：10.1021/ja00374a031

  日期：1982.5
• Structure of .omega.-arylalkyl radicals: a carbon-13 CIDNP investigation
  作者：George A. Olah、V. V. Krishnamurthy、Brij P. Singh、Pradeep S. Iyer

  DOI：10.1021/jo00155a006

  日期：1983.4

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