3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanoic acid | 1202273-69-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanoic acid
• 英文别名: 3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid；3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)-phenyl]-propionic acid；3-Imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanoic acid
• CAS: 1202273-69-5
• 化学式: C₂₄H₂₃N₃O₂
• 分子量: 385.466
• InChiKey: RTYXQMMUWJBPMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  67.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanoic acid 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 氨 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 反应 0.5h， 以71%的产率得到3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanamide
  参考文献：
  名称：

  作为视黄酸小分子抑制剂的3-（1 H-咪唑-和三唑-1-基）-2,2-二甲基-3- [4-（萘-2-基氨基）苯基]丙基衍生物的合成及生物学评价4-羟化酶（CYP26）

  摘要：

  新型3-（1 H-咪唑-和三唑-1-基）-2,2-二甲基-3-（4-（萘-2-基氨基）苯基）丙基衍生物的合成及其强抑制活性描述了7种CYP26A1微粒体测定法。这项研究的重点是修饰血红素结合唑基和柔性C3链对抑制活性和选择性的影响。最有希望的抑制剂2,2-二甲基-3- [4-（萘-2-基氨基）-苯基] -3- [1,2,4]三唑-1-基-丙酸甲酯（17）（IC与利拉唑IC 50 = 540 nM和R116010 IC 50 = 10 nM相比，评估了50 = 0.35 nM的CYP选择性和肝稳定性。具有CYP26抑制IC 50的化合物值≤50nM增强外源性ATRA的生物活性，与单独使用ATRA相比，SH-SY5Y神经母细胞瘤细胞中CYP26A1 mRNA的增加3.7-5.8倍证明了这一点。所有化合物均显示出与R116010相当或更好的活性，且诱导作用与CYP26抑制数据密切相关。这些研究突

  DOI：

  10.1021/jm200695m
• 作为产物：
  描述：

  3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester 在 N,N'-羰基二咪唑 、 potassium hydroxide 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 73.0h， 生成 3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanoic acid
  参考文献：
  名称：

  [EN] CYP26 INHIBITORS
  [FR] INHIBITEURS DE CYP26

  摘要：

  公式（I）的化合物，其中X选择自O、S、NH或CH2；Rd和Rp是可选的萘基取代物；RHet是咪唑基、三唑基或吡啶基；Rc是C1-4烷基，通过选择的基团取代，包括：羟基、氨基、酰胺基、羧基、C1-7烷基酯、C5-7芳基-C1-2烷基酯、磺胺基、亚砜胺基、羟胺基和四唑基。

  公开号：

  WO2009153566A1

文献信息

• IMIDAZOLE COMPOUND, METAL SURFACE TREATMENT LIQUID, METAL SURFACE TREATMENT METHOD, AND LAMINATE PRODUCTION METHOD
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20170247334A1

  公开（公告）日：2017-08-31

  A novel imidazole compound that yields a surface treatment liquid that is very effective at suppressing migration and oxidation of a wiring surface; a metal surface treatment liquid that contains the imidazole compound; a metal surface treatment method that uses the metal surface treatment liquid; and a laminate production method that uses the surface treatment liquid. A metal is surface-treated using the surface treatment liquid which includes a saturated fatty acid or a saturated fatty acid ester of a specific structure, in which a prescribed position is substituted by an aromatic group of a prescribed structure and an imidazolyl group that may have a substituent group.

  一种新型咪唑化合物，可产生一种表面处理液，该液非常有效地抑制导线表面的迁移和氧化；一种含有咪唑化合物的金属表面处理液；一种使用金属表面处理液的金属表面处理方法；以及一种使用表面处理液的层压板生产方法。使用包含饱和脂肪酸或饱和脂肪酸酯的表面处理液对金属进行表面处理，其中，预定位置被预定结构的芳基取代，并且可能带有取代基的咪唑基。
• CURABLE COMPOSITION
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：EP3228641A1

  公开（公告）日：2017-10-11

  Provided are: a curable composition that can be cured at low temperature in a short time regardless of the type of epoxy compound that is mixed therewith, and has a long pot life; an adhesive comprising said curable composition; a method for producing a fiber-reinforced composite material that uses the curable composition; and a fiber-reinforced composite material containing a matrix comprising the curable composition. Furthermore, the present invention provides a curing agent mixture composition that can be cured at low temperature and in a short time, and provides the curable composition with a long pot life. Furthermore, provided is a curing agent mixture composition that can be cured at low temperature and in a short time, and provides the curable composition with a long pot life. An epoxy compound (A) and an imidazole compound (B) having a specific structure are blended in with the curable composition. In addition, the imidazole compound (B) having a specific structure and at least one type of crosslinking agent (C) selected from the group comprising a polyvalent amide compound and a polyvalent carboxylic acid anhydride are blended in with the curing agent mixture composition.

  本发明提供了：一种可固化组合物，无论与哪种环氧化合物混合，都能在短时间内低温固化，并具有较长的固化寿命；一种包含所述可固化组合物的粘合剂；一种使用该可固化组合物生产纤维增强复合材料的方法；以及一种含有包含该可固化组合物的基体的纤维增强复合材料。此外，本发明还提供了一种固化剂混合物组合物，可在低温和短时间内固化，并使固化组合物具有较长的固化寿命。此外，本发明还提供了一种固化剂混合物组合物，可在低温和短时间内固化，并使固化组合物具有较长的固化寿命。环氧化合物（A）和具有特定结构的咪唑化合物（B）与固化剂混合物混合。此外，具有特定结构的咪唑化合物（B）和至少一种从包括多价酰胺化合物和多价羧酸酐的组中选出的交联剂（C）也混入固化剂混合物中。
• Hydrogen barrier agent, hydrogen barrier film forming composition, hydrogen barrier film, method for producing hydrogen barrier film, and electronic element
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US10023540B2

  公开（公告）日：2018-07-17

  To provide a hydrogen barrier agent capable of imparting hydrogen barrier performance to various materials; a hydrogen barrier film forming composition including the hydrogen barrier agent; a hydrogen barrier film including the hydrogen barrier agent; a method for producing a hydrogen barrier film, which uses the hydrogen barrier film forming composition; and an electronic element provided with the hydrogen barrier film. A compound having a specific structure including an imidazolyl group is used as the hydrogen barrier agent. Furthermore, the hydrogen barrier film forming composition is prepared by blending the above-mentioned hydrogen barrier agent into the base material component. In addition, the hydrogen barrier film is formed using the hydrogen barrier film forming composition.

  提供一种能使各种材料具有氢阻隔性能的氢阻隔剂；一种包括该氢阻隔剂的氢阻隔薄膜形成组合物；一种包括该氢阻隔剂的氢阻隔薄膜；一种使用该氢阻隔薄膜形成组合物生产氢阻隔薄膜的方法；以及一种带有该氢阻隔薄膜的电子元件。氢阻隔剂使用了一种具有特定结构的化合物，其中包括咪唑基团。此外，氢阻隔膜形成组合物是通过将上述氢阻隔剂与基础材料成分混合而制备的。此外，使用氢阻隔膜形成组合物形成氢阻隔膜。
• Curable composition
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US10239989B2

  公开（公告）日：2019-03-26

  A curable composition that can be cured at low temperature in a short time regardless of the type of epoxy compound that is mixed therewith, and has a long pot life; an adhesive comprising said curable composition; a method for producing a fiber-reinforced composite material that uses the curable composition; and a fiber-reinforced composite material containing a matrix comprising the curable composition. A curing agent mixture composition that can be cured at low temperature and in a short time, and provides the curable composition with a long pot life. An epoxy compound (A) and an imidazole compound (B) are blended in with the curable composition. In addition, the imidazole compound (B) and at least one type of crosslinking agent (C) are blended in with the curing agent mixture composition.

  一种可在短时间内低温固化的固化组合物，无论与之混合的环氧化合物类型如何，均具有较长的固化寿命；一种包含所述固化组合物的粘合剂；一种使用该固化组合物生产纤维增强复合材料的方法；以及一种含有包含该固化组合物的基体的纤维增强复合材料。一种固化剂混合物组合物，可在低温和短时间内固化，并使固化组合物具有较长的固化寿命。环氧化合物（A）和咪唑化合物（B）与可固化组合物混合。此外，咪唑化合物（B）和至少一种交联剂（C）也混入固化剂混合物中。
• Imidazole compound, metal surface treatment liquid, metal surface treatment method, and laminate production method
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US10336708B2

  公开（公告）日：2019-07-02

  A novel imidazole compound that yields a surface treatment liquid that is very effective at suppressing migration and oxidation of a wiring surface; a metal surface treatment liquid that contains the imidazole compound; a metal surface treatment method that uses the metal surface treatment liquid; and a laminate production method that uses the surface treatment liquid. A metal is surface-treated using the surface treatment liquid which includes a saturated fatty acid or a saturated fatty acid ester of a specific structure, in which a prescribed position is substituted by an aromatic group of a prescribed structure and an imidazolyl group that may have a substituent group.

  一种新型咪唑化合物，它能产生一种非常有效地抑制线路表面迁移和氧化的表面处理液；一种含有该咪唑化合物的金属表面处理液；一种使用该金属表面处理液的金属表面处理方法；以及一种使用该表面处理液的层压板生产方法。使用表面处理液对金属进行表面处理，该表面处理液包括特定结构的饱和脂肪酸或饱和脂肪酸酯，其中规定的位置被规定结构的芳香基团和可能具有取代基团的咪唑基团取代。