Tropigline | 533-08-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Tropigline
• 英文别名: (E)-tropan-3α-yl 2-methylbutenoate；3α-tigloyloxytropane；tiglic acid tropane-3endo-yl ester；Tiglinsaeure-tropan-3endo-ylester；3α-Tigloyloxy-tropan
• CAS: 533-08-4
• 化学式: C₁₃H₂₁NO₂
• 分子量: 223.315
• InChiKey: UVHGSMZRSVGWDJ-LKQNJMEQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.12
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  29.54
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  (E)-2-甲基-2-丁烯酰氯 、 3-tropanol 生成 Tropigline
  参考文献：
  名称：

  Al-Said, Mansour S.; Evans, William C.; Grout, Raymond J., Journal of the Chemical Society. Perkin transactions I, 1986, p. 957 - 960

  摘要：

  DOI：

文献信息

• Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura
  作者：Henry D. Boswell、Birgit Dräger、W.Russell McLauchlan、Andreas Portsteffen、David J. Robins、Richard J. Robins、Nicholas J. Walton

  DOI：10.1016/s0031-9422(99)00293-9

  日期：1999.11

  The enzymes N-methylputrescine oxidase (MPO), the tropine-forming tropinone reductase (TRI), the pseudotropine-forming tropinone reductase (TRII), the tropine:acyl-CoA transferase (TAT) and the pseudotropine:acyl-CoA transferase (PAT) extracted from transformed root cultures of Datura stramonium and a Brugmansia candida x aurea hybrid were tested for their ability to accept a range of alternative substrates

  酶 N-甲基腐胺氧化酶 (MPO)、形成托品的托品酮还原酶 (TRI)、形成假托品的托品酮还原酶 (TRII)、托品：酰基辅酶 A 转移酶 (TAT) 和拟托品：酰基辅酶 A 转移酶 (PAT) ) 从曼陀罗和 Brugmansia candida x aurea 杂交体的转化根培养物中提取的 ) 接受了一系列替代底物的能力进行了测试。MPO 活性用 N-烷基腐胺和 N-烷基尸胺作为底物进行测试。针对一系列 N-烷基去甲托品酮、N-烷基去甲片碱和结构相关的酮作为底物测试了 TRI 和 TRII 还原。TAT 和 PAT 酯化测试使用一系列 N 取代的托品、拟托品、丸剂和拟丸剂作为底物来评估它们各自的乙酰基酯和 tigloyl 酯的形成。结果通常表明，这些酶会在不同程度上接受外来底物。这样的研究可能会揭示有关酶的活性位点的整体拓扑结构。
• Barger et al., Journal of the Chemical Society, 1937, p. 1820,1823
  作者：Barger et al.

  DOI：——

  日期：——
• METHOD OF SENSITIZING CANCER CELLS TO THE CYTOTOXIC EFFECTS OF DEATH RECEPTOR LIGANDS IN CANCER TREATMENT
  申请人：Sayers Thomas Joseph

  公开号：US20130039883A1

  公开（公告）日：2013-02-14

  Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.
• Method of Improving the Growth and Production Output of Plants of the Family Solanaceae
  申请人：Ankner Charles E.

  公开号：US20170280643A1

  公开（公告）日：2017-10-05

  A method and system of improving the growth of plants belonging to the family Solanaceae by providing a plant nutrient solution about the plant roots and a gas mixture circulating about the plant shoot; by selecting the gas mixture and plant nutrient solution temperature independently of the other; and providing a plant nutrient solution to gas mixture temperature differential of approximately at least approximately 10° F. during different phases of plant development. The method and system improves plant development to improve a desired plant organ for industrial, scientific, and medical purposes. A method of improving the growth and development of Solanaceae plants by providing a shoot-to-root temperature differential to treat or prevent infection by a plant pathogen and/or infestation by pests.
• US6866872B1
  申请人：——

  公开号：US6866872B1

  公开（公告）日：2005-03-15