O,O-diethyl N-methylamino(phenyl)methylphosphonate | 51909-56-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: O,O-diethyl N-methylamino(phenyl)methylphosphonate
• 英文别名: diethyl [(methylamino)(phenyl)methyl]phosphonate；diethyl (α-methylamino)benzylphosphonate；diethyl N-methylamino(phenyl)methylphosphonate；diethyl (aminophenylmethyl)phosphonate；diethyl methylaminobenzylphosphonate；α-Methylamino-benzylphosphonsaeurediaethylester；Phosphonic acid, [(methylamino)phenylmethyl]-, diethyl ester；1-diethoxyphosphoryl-N-methyl-1-phenylmethanamine
• CAS: 51909-56-9
• 化学式: C₁₂H₂₀NO₃P
• 分子量: 257.269
• InChiKey: CGQXIFHQRDVVEX-UHFFFAOYSA-N

物化性质

• 沸点：
  123 °C(Press: 1 Torr)
• 密度：
  1.096±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  O,O-diethyl N-methylamino(phenyl)methylphosphonate 在 ammonium sulfate 作用下， 反应 26.0h， 生成 {[Methyl-(1-methyl-1-trimethylsilanyloxy-ethyl)-amino]-phenyl-methyl}-phosphonic acid diethyl ester
  参考文献：
  名称：

  Pudovik; Saakyan; Khairullin, Russian Journal of General Chemistry, 1997, vol. 67, # 12, p. 1878 - 1880

  摘要：

  DOI：
• 作为产物：
  描述：

  {[Methyl-(phenyl-trimethylsilanyloxy-methyl)-amino]-phenyl-methyl}-phosphonic acid diethyl ester 以 甲醇 为溶剂， 反应 2.0h， 生成 O,O-diethyl N-methylamino(phenyl)methylphosphonate
  参考文献：
  名称：

  Pudovik; Saakyan; Khairullin, Russian Journal of General Chemistry, 1997, vol. 67, # 12, p. 1878 - 1880

  摘要：

  DOI：

文献信息

• Synthesis of the new adducts of imines and enamines with PH acids and their derivatives
  作者：Andrey A. Prishchenko、Mikhail V. Livantsov、Olga P. Novikova、Ludmila I. Livantsova、Elena R. Milaeva

  DOI：10.1002/hc.20513

  日期：——

  organophosphorus acids with PH fragments to various imines and enamines is proposed as convenient methods for the synthesis of new substituted aminomethyl organophosphorus compounds with three-, four-, and five-coordinated phosphorus. Also the new functionalized derivatives of these compounds with acyl and methanesulfonyl moieties are synthesized, and some properties of the obtained compounds are presented

  三价有机磷酸与 PH 片段的酯与各种亚胺和烯胺的亲核或自由基加成被认为是合成具有三、四和五配位磷的新型取代氨基甲基有机磷化合物的便捷方法。还合成了这些具有酰基和甲磺酰基部分的化合物的新官能化衍生物，并介绍了所得化合物的一些性质。© 2009 Wiley Periodicals, Inc. 杂原子化学 20:70–80, 2009; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.20513
• Synthesis of phosphonamides of methane- and benzenesulfonic acids bearing the P—C—N fragments
  作者：A. A. Prishchenko、M. V. Livantsov、O. P. Novikova、L. I. Livantsova、V. S. Petrosyan

  DOI：10.1007/s11172-017-1825-5

  日期：2017.5

  Preparative synthetic procedures towards new phosphorus-containing benzenesulfon-amides were elaborated. The synthesis is involved the reactions of trivalent phosphorus acids with high reactive N-methyl-N-chloromethylsulfonamide, phosphorylated methylamines bearing the NH and NSi groups, and methane-and benzenesulfonyl chlorides.

  详细阐述了新的含磷苯磺酰胺的制备合成程序。该合成涉及三价磷酸与高活性 N-甲基-N-氯甲基磺酰胺、带有 NH 和 NSi 基团的磷酸化甲胺以及甲烷和苯磺酰氯的反应。
• New functionalized organophosphorus derivatives of methane- and ethanesulfonic acids with P-C-N moieties
  作者：Andrey A. Prishchenko、Mikhail V. Livantsov、Olga P. Novikova、Ludmila I. Livantsova、Valery S. Petrosyan

  DOI：10.1080/10426507.2016.1252369

  日期：2017.2.1

  syntheses of new organophosphorus alkanesulfonylamides from the trivalent organophosphorus acid esters and reactive N-methyl N-chloromethyl methanesulfonylamide, phosphorylated methylamines with NH- and NSi moieties, trimethylsilyl vinylsulfonate, and N,N-diethylvinylsulfonamide were developed. The new types of functionalized organophosphorus derivatives of methane- and ethanesulfonic acids with P-C-N

  图形摘要摘要开发了从三价有机磷酸酯和反应性 N-甲基 N-氯甲基甲磺酰胺、具有 NH- 和 NSi 部分的磷酸化甲胺、乙烯基磺酸三甲基甲硅烷酯和 N,N-二乙基乙烯基磺酰胺合成新型有机磷烷烃磺酰胺的便捷方法。具有 PCN 部分的新型功能化的甲磺酸和乙磺酸有机磷衍生物以良好的收率获得。
• Prokof'eva, A. F.; Aleshnikova, T. V.; Nazarova, E. B., Journal of general chemistry of the USSR, 1983, vol. 53, # 2, p. 280 - 283
  作者：Prokof'eva, A. F.、Aleshnikova, T. V.、Nazarova, E. B.、Mel'nikov, N. N.

  DOI：——

  日期：——
• ——
  作者：M. M. Kabachnik、T. N. Ternovskaya、E. V. Zobnina、I. P. Beletskaya

  DOI：10.1023/a:1016578602100

  日期：——

  The reaction of hydrophosphoryl compounds with aldimines and ketimines in the presence of catalytic amounts of cadmium iodide was investigated. A simple preparative method for the synthesis of alpha-aminophosphonates, phosphinates, and tertiary phosphine oxides was developed.