cis-4-Methoxy-3'-nitro-stilben | 17555-96-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: cis-4-Methoxy-3'-nitro-stilben
• 英文别名: cis-4-Methoxy-4'-nitro-stilben；(Z)-1-methoxy-4-[2-(3-nitrophenyl)ethenyl]benzene；(Z)-1-(4-methoxystyryl)-3-nitrobenzene；1-[(Z)-2-(4-methoxyphenyl)ethenyl]-3-nitrobenzene
• CAS: 17555-96-3
• 化学式: C₁₅H₁₃NO₃
• 分子量: 255.273
• InChiKey: OQTPCVHPYCNENY-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-4-Methoxy-3'-nitro-stilben 在 硫酸 作用下， 以 乙醇 为溶剂， 生成 (E)-4-methoxy-3'-nitrostilbene
  参考文献：
  名称：

  The kinetics and mechanism of the acid-catalyzed isomerization of cis-stilbene

  摘要：

  DOI：

  10.1021/ja01019a021
• 作为产物：
  描述：

  对甲氧基苯乙酸 在 喹啉 、 copper chromite 作用下， 生成 cis-4-Methoxy-3'-nitro-stilben
  参考文献：
  名称：

  The kinetics and mechanism of the acid-catalyzed isomerization of cis-stilbene

  摘要：

  DOI：

  10.1021/ja01019a021

文献信息

• Microwave-Assisted Wittig Reaction of Semistabilized Nitro-Substituted Benzyltriphenyl-Phosphorous Ylides with Aldehydes in Phase-Transfer Conditions
  作者：Tiago Rodrigues、Francisca Lopes、Rui Moreira

  DOI：10.1080/00397911.2010.530378

  日期：2012.3.1

  Abstract We report here a simple entry into the nitrostilbene system in very short reaction times and good yields using the microwave-assisted Wittig reaction in phase-transfer conditions of nitro-substituted benzyltriphenylphosphonium ylides with aldehydes. GRAPHICAL ABSTRACT

  摘要 我们在此报告了在硝基取代的苄基三苯基鏻叶立德与醛的相转移条件下，使用微波辅助的 Wittig 反应，在非常短的反应时间和良好的收率下简单地进入硝基二苯乙烯系统。图形概要
• Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonists
  作者：Kazunori Motoshima、Tomomi Noguchi-Yachide、Kazuyuki Sugita、Yuichi Hashimoto、Minoru Ishikawa

  DOI：10.1016/j.bmc.2009.05.066

  日期：2009.7

  Liver X receptor (LXR) alpha/beta dual agonists are candidate medicaments for the treatment of metabolic syndrome, because their biological actions include increasing cholesterol efflux mediated by LXR beta. However, their clinical application is currently limited by their enhancing effect on triglyceride (TG) synthesis mediated by LXR alpha. Combination of an LXR alpha-selective antagonist with an LXR alpha/beta dual agonist may overcome this disadvantage. In the present work, structural development studies of phenethylphenyl phthalimide 9, which possesses LXR alpha/beta dual-antagonistic activity and alpha-glucosidase-inhibitory activity, led to the LXR alpha-selective antagonist 23f. Specific alpha-glucosidase inhibitors were also obtained. (C) 2009 Elsevier Ltd. All rights reserved.