2,5,7,8-Tetramethyl-2-<4-methyl-pent-3-enyl>-chrom-3-en-6-ol | 3726-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,5,7,8-Tetramethyl-2-<4-methyl-pent-3-enyl>-chrom-3-en-6-ol
• 英文别名: 2H-1-Benzopyran-6-ol, 2,5,7,8-tetramethyl-2-(4-methyl-3-pentenyl)-；2,5,7,8-tetramethyl-2-(4-methylpent-3-enyl)chromen-6-ol
• CAS: 3726-80-5
• 化学式: C₁₉H₂₆O₂
• 分子量: 286.414
• InChiKey: LXMAAKXXPANYRE-UHFFFAOYSA-N

物化性质

• 沸点：
  102-108 °C(Press: 1 Torr)
• 密度：
  1.011±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,5,7,8-Tetramethyl-2-<4-methyl-pent-3-enyl>-chrom-3-en-6-ol 在 吡啶 、 barium dihydroxide 、 氧气 、 臭氧 作用下， 以 水 、 丙酮 为溶剂， 反应 3.08h， 生成 (RS)-2,5,7,8-tetramethyl-2-(3-oxoprop-1-yl)-6-acetoxy-3-chromene
  参考文献：
  名称：

  摘要：

  The reactions of trimethylhydroquinone with isoprenoid allylic alcohols catalyzed by a Pentasil type zeolite in the H-form gave trimethyl-1,4-benzoquinones with the corresponding isoprenoid group, which were subsequently transformed into the target Delta(3)-chromenes oil treatment with pyridine. Partial ozonolysis of chromenes proceeded selectively at the Delta-bond of the side chain, resulting in the corresponding chromenes with an omega-carbonyl group.

  DOI：

  10.1023/a:1015528923267
• 作为产物：
  描述：

  芳樟醇 在 吡啶 、 Pentasil ZSM-5/11 作用下， 以 various solvent(s) 为溶剂， 反应 21.5h， 生成 2,5,7,8-Tetramethyl-2-<4-methyl-pent-3-enyl>-chrom-3-en-6-ol
  参考文献：
  名称：

  摘要：

  The reactions of trimethylhydroquinone with isoprenoid allylic alcohols catalyzed by a Pentasil type zeolite in the H-form gave trimethyl-1,4-benzoquinones with the corresponding isoprenoid group, which were subsequently transformed into the target Delta(3)-chromenes oil treatment with pyridine. Partial ozonolysis of chromenes proceeded selectively at the Delta-bond of the side chain, resulting in the corresponding chromenes with an omega-carbonyl group.

  DOI：

  10.1023/a:1015528923267

文献信息

• Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia
  申请人：Bristol-Myers Squibb Company

  公开号：US05217992A1

  公开（公告）日：1993-06-08

  This invention relates to the use of tocotrienol, gamma-tocotrienol and delta-tocotrienol in reducing hypercholesterolemia, hyperlipidemia and thromboembolic disorders in mammals. [The isolation of these tocotrienols from natural sources and their chemical synthesis is disclosed.] The chemical synthesis of these tocotrienols is disclosed. The present invention also relates to prodrugs and pharmaceutical compositions of gamma-tocotrienol, delta-tocotrienol and tocotrienol and uses thereof.

  这项发明涉及在哺乳动物中减少高胆固醇血症、高脂血症和血栓栓塞疾病中使用生育三烯酚、γ-生育三烯酚和δ-生育三烯酚。[从天然来源中分离这些生育三烯酚及其化学合成已被披露。]这些生育三烯酚的化学合成已被披露。本发明还涉及γ-生育三烯酚、δ-生育三烯酚和生育三烯酚的前药和药物组合物及其用途。
• SVISHCHUK A. A.; VYSOTSKIJ N. N., UKR. XIM. ZH. <UKZN-AU>, 1975, 41, HO 5, 506-509
  作者：SVISHCHUK A. A.、 VYSOTSKIJ N. N.

  DOI：——

  日期：——
• US5217992A
  申请人：——

  公开号：US5217992A

  公开（公告）日：1993-06-08
• US5348974A
  申请人：——

  公开号：US5348974A

  公开（公告）日：1994-09-20
• ——
  作者：V. N. Odinokov、A. Yu. Spivak、G. A. Emel"yanova、B. I. Kutepov

  DOI：10.1023/a:1015528923267

  日期：——

  The reactions of trimethylhydroquinone with isoprenoid allylic alcohols catalyzed by a Pentasil type zeolite in the H-form gave trimethyl-1,4-benzoquinones with the corresponding isoprenoid group, which were subsequently transformed into the target Delta(3)-chromenes oil treatment with pyridine. Partial ozonolysis of chromenes proceeded selectively at the Delta-bond of the side chain, resulting in the corresponding chromenes with an omega-carbonyl group.