(1-chloroethyl)phosphonyl dichloride | 22864-41-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: (1-chloroethyl)phosphonyl dichloride
• 英文别名: 1-Chlorethanphosponsaeuredichlorid；1-chloroethylphosphonic dichloride；(1-chloro-ethyl)-phosphonic acid dichloride；(1-Chlor-aethyl)-phosphonsaeure-dichlorid；(1-Chlor-aethyl)-phosphonylchlorid；dichoro-(1-chloroethyl)-phosphine oxide；(1-Chloroethyl)phosphonic dichloride；1-chloro-1-dichlorophosphorylethane
• CAS: 22864-41-1
• 化学式: C₂H₄Cl₃OP
• 分子量: 181.386
• InChiKey: SPYUGXBMJVRZBP-UHFFFAOYSA-N

物化性质

• 沸点：
  70 °C(Press: 8 Torr)
• 密度：
  1.5424 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1-chloroethyl)phosphonyl dichloride 在 水 作用下， 生成 (1-chloro-ethyl)-phosphonic acid
  参考文献：
  名称：

  Jakubowitsch; Ginsburg, Zhurnal Obshchei Khimii, 1952, vol. 22, p. 1534,1540; engl. Ausg. S. 1575, 1581

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-二氯乙烷 在 三氯化铝 、 三氯化磷 作用下， 生成 (1-chloroethyl)phosphonyl dichloride
  参考文献：
  名称：

  in vivo Cell Lineage Analysis During Chemical Hepatocarcinogenesis in Rats Using Retroviral-Mediated Gene Transfer: Evidence for Dedifferentiation of Mature Hepatocytes

  摘要：

  Feeding adult rats with a diet containing 2-acetylaminofluorene (2-AAF) results in suppression of hepatocyte proliferation and stimulation of oval cell proliferation. Although oval cells may be facultative liver stem cells, the actual relationship between oval cells and liver cancer has not been clearly established in vivo. Our goal was to label hepatic cells in vivo using retroviral vectors and follow their fate during the early steps of chemically induced hepatocarcinogenesis. Oval cell proliferation was induced by continuous feeding with a carcinogenic diet containing 2-AAF. We used two different strategies to genetically label hepatic cells: (a) labeling of proliferating cells in rats fed 2-AAF by injecting recombinant retroviral vectors containing the beta-galactosidase gene either in a peripheral vein or in the common bile duct at the peak of oval cell proliferation and (b) prelabeling of hepatocytes by intravenously injecting recombinant vectors 1 day after partial hepatectomy and 1 week before subsequent administration of 2-AAF. Using the first strategy, transgene expression occurred in both oval cells and hepatocytes. Using the second strategy, we could selectively label, and hence study the fate of, differentiated hepatocytes. In the latter case, we observed clusters of beta-galactosidase-positive hepatocytes, some of them also expressing preneoplastic markers such as gamma-glutamyl transpeptidase as well as the placental form of glutathione-S-transferase. These results demonstrate that preneoplastic foci can originate from mature hepatocytes and are consistent with the hypothesis that dedifferentiation of mature hepatocytes may occur during the course of carcinogenic regimen.

  DOI：

  10.1097/01.lab.0000017363.11489.ad

文献信息

• Methoxide-induced rearrangement of some N-t-butyl α-chlorophosphonamidates evidence for azaphosphiridine oxide intermediates
  作者：Martin J.P Harger、Andrew Williams

  DOI：10.1016/s0040-4039(00)84517-7

  日期：——

  -t-Butyl α-chlorophosphonamidates () undergo methoxide-induced rearrangement to give products ( and ) in which either the P-N or PC bond has been broken. This implies the intermediacy of a cyclic azaphosphiridine oxide .

  α-氯代膦酸叔丁基酯（）受到甲醇盐诱导的重排，生成PN或PC键已断裂的产物（和）。这暗示着环状氮杂磷吡啶氧化物的中间体。
• Patois, C.; Berte-Verrando, S.; Savignac, P., Bulletin de la Societe Chimique de France, 1993, vol. 130, p. 485 - 487
  作者：Patois, C.、Berte-Verrando, S.、Savignac, P.

  DOI：——

  日期：——
• Bauer, Gert; Haegele, Gerhard; Sartori, Peter, Phosphorus and Sulfur and the Related Elements, 1980, vol. 8, p. 95 - 98
  作者：Bauer, Gert、Haegele, Gerhard、Sartori, Peter

  DOI：——

  日期：——
• Harger, Martin J. P.; Williams, Andrew, Journal of the Chemical Society. Perkin transactions I, 1986, p. 1681 - 1686
  作者：Harger, Martin J. P.、Williams, Andrew

  DOI：——

  日期：——
• Kabatschnik; Schepelewa, Doklady Akademii Nauk SSSR, 1950, vol. 75, p. 219,220
  作者：Kabatschnik、Schepelewa

  DOI：——

  日期：——