1-(4-dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-propan-1-one | 1035495-01-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 1-(4-dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-propan-1-one
• 英文别名: 1-(4-Benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)propan-1-one
• CAS: 1035495-01-2
• 化学式: C₂₀H₂₁N₃OS
• 分子量: 351.472
• InChiKey: UEBRXMASPQYHGG-UHFFFAOYSA-N

物化性质

• 沸点：
  549.7±60.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  11-(1-哌嗪基)二苯并[B,F][1,4]硫氮杂卓 、 丙酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 1-(4-dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-propan-1-one
  参考文献：
  名称：

  WO2008/79838

  摘要：

  公开号：

文献信息

• COMPOUNDS AND USES THEREOF - 177
  申请人：Bernstein Peter

  公开号：US20100093699A1

  公开（公告）日：2010-04-15

  This invention relates to novel compounds having the structural Formula (I) below: and their pharmaceutically acceptable salts, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of at least one symptom or condition associated with schizophrenia and other psychotic disorders, dementia and other cognitive disorders, anxiety disorders, mood disorders, sleep disorders, disorders usually first diagnosed in infancy, childhood, or adolescence, and neurodegenerative disorders.
• [EN] COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ET LEURS UTILISATIONS
  申请人：ASTRAZENECA AB

  公开号：WO2008079838A1

  公开（公告）日：2008-07-03

  [EN] This invention relates to novel compounds having the structural Formula (I) below:and their pharmaceutically acceptable salts, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of at least one symptom or condition associated with schizophrenia and other psychotic disorders, dementia and other cognitive disorders, anxiety disorders, mood disorders, sleep disorders, disorders usually first diagnosed in infancy, childhood, or adolescence, and neurodegenerative disorders.
  [FR] L'invention concerne de nouveaux composés représentés par la formule développée (I), ainsi que leurs sels pharmaceutiquement acceptables, des compositions contenant ces composés et des procédés d'utilisation de ces composés. Ces nouveaux composés permettent de traiter ou de prévenir au moins un symptôme ou un état associé à la schizophrénie et à d'autres troubles psychotiques, la démence et d'autres troubles cognitifs, des troubles anxieux, des troubles de l'humeur, des troubles du sommeil, des troubles habituellement diagnostiqués pour la première fois pendant la petite enfance, l'enfance ou l'adolescence et des troubles neurodégénératifs.
• [EN] NOVEL DERIVATIVES OF 11-PIPERAZIN-L-YLDIBENZO [B,F] [L,4] THIAZEPINE FOR TREATING AT LEAST ONE SYNDROME OR CONDITION ASSOCIATED WITH SCHIZOPHRENIA AND OTHER PSYCHOTIC DISORDERS<br/>[FR] NOUVEAUX DÉRIVÉS DE LA 11-PIPÉRAZIN-L-YLDIBENZO[B,F][L,4]THIAZÉPINE POUR TRAITER AU MOINS UN SYNDROME OU UN ÉTAT ASSOCIÉ À LA SCHIZOPHRÉNIE ET AUTRES TROUBLES PSYCHOTIQUES
  申请人：ASTRAZENECA AB

  公开号：WO2009151393A1

  公开（公告）日：2009-12-17

  This invention relates to novel compounds having the structural Formula I below: (I) and their pharmaceutically acceptable salts, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of at least one symptom or condition associated with schizophrenia and other psychotic disorders, dementia and other cognitive disorders, anxiety disorders, mood disorders, sleep disorders, disorders usually first diagnosed in infancy, childhood, or adolescence, and neurodegenerative disorders.
• WO2008/79838
  申请人：——

  公开号：——

  公开（公告）日：——