3-butenyltributylstannane | 36635-36-6

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• 英文名称: 3-butenyltributylstannane
• CAS: 36635-36-6
• 化学式: C₁₆H₃₄Sn
• 分子量: 345.156
• InChiKey: JDFFKGOJOSVFJB-UHFFFAOYSA-N

物化性质

• 沸点：
  328.9±35.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.41
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  3-butenyltributylstannane 在 HgCl₂ 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 三正丁基溴化锡
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Sn: Org.Verb.2, 1.1.2.5.4, page 307 - 315

  摘要：

  DOI：
• 作为产物：
  描述：

  三丁基氯化锡 、 3-Butenylmagnesium bromide 以 四氢呋喃 为溶剂， 以81%的产率得到3-butenyltributylstannane
  参考文献：
  名称：

  A simple method for preparing some cyclopropylcarbinyl compounds

  摘要：

  DOI：

  10.1016/s0040-4039(01)84787-0

文献信息

• DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR
  申请人：Carnegie Mellon University

  公开号：US20160083434A1

  公开（公告）日：2016-03-24

  Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.

  本文描述了一种新颖的二价核碱基，每个核碱基可以结合两条核酸链，无论是匹配还是不匹配，当它们被合并到核酸或核酸类似物的骨架中（一种遗传识别试剂，或遗传识别试剂）。在一个实施例中，遗传识别试剂是肽核酸（PNA）或γ PNA（？PNA）寡聚体。还提供了含有二价核碱基的单体和遗传识别试剂的用途。
• [EN] MACROCYCLIC COMPOUNDS HAVING ASPARTIC PROTEASE INHIBITING ACTIVITY AND PHARMACEUTICAL USES THEREOF<br/>[FR] COMPOSES MACROCYLIQUES PRESENTANT UNE ACTIVITE D'INHIBITION DE PROTEASE ASPARTIQUE ET UTILISATIONS PHARMACEUTIQUES DE CEUX-CI
  申请人：NOVARTIS AG

  公开号：WO2005003106A1

  公开（公告）日：2005-01-13

  The present invention relates to macrocyclic compounds of formula (I), wherein R1, is (C1-8)alkyl, (C1-4)alkoxy(C1-4)alkyl, hydroxy(C1-6)alkyl, (C1-4)alkylthio(C1-4)alkyl, (C1-6)alkenyl, (C3-­7)cycloalkyl, (C3-7)cycloalkyl(C1-4)alkyl, piperidinyl or pyrrolidinyl, R2 and R4, independently, are hydrogen or optionally substituted (C1-8)alkyl, (C3-7) cycloalkyl, (C3-7)cycloalkyl(C1-4)alkyl, aryl, aryl(C1-4)alkyl, heteroaryl or heteroaryl(C1-4) alkyl, or R2 and R4, together with the nitrogen to which they are attached, form an optionally substituted piperidino, pyrrolidinyl, morpholino or piperazinyl group, R3 is hydrogen or (C1-4)alkyl, X1 is CH2, X2 is CH2, O, S, CO, COO, OCO, NHCO, CONH, or NR, R being hydrogen or (C1-4)alkyl, Y is (C1-8)alkylen or (C1-­8)alkylenoxy(C1-6)alkylen, (C1-8)alkenylen or (C1-8)alkenylenoxy(C1-6)alkylen, Ar is a phenyl ring optionally mono- di­ or trisubstituted by, independently, hydroxy or halogen, whereby X1, and X2 are in meta or para position to each other, and either Z is CO, AA is a natural or unnatural alpha-amino-acid, and n is 0 or 1, or Z is S02, AA is an optionally substituted ethylencarbonyl group (derived from a natural or unnatural alpha-amino acid by replacement of the nitrogen by a methylen group), and n is 1; processes for the preparation of these compounds; pharmaceutical compositions and combinations comprising the same; and their use in the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation.

  本发明涉及式(I)的大环化合物，其中R1为(C1-8)烷基，(C1-4)烷氧基(C1-4)烷基，羟基(C1-6)烷基，(C1-4)烷基硫基(C1-4)烷基，(C1-6)烯基，(C3-7)环烷基，(C3-7)环烷基(C1-4)烷基，哌啶基或吡咯啉基，R2和R4，独立地，为氢或可选择取代的(C1-8)烷基，(C3-7)环烷基，(C3-7)环烷基(C1-4)烷基，芳基，芳基(C1-4)烷基，杂环芳基或杂环芳基(C1-4)烷基，或R2和R4与它们连接的氮一起形成可选择取代的哌啶基，吡咯啉基，吗啉基或哌嗪基，R3为氢或(C1-4)烷基，X1为CH2，X2为 ，O，S，CO，COO，OCO，NHCO，CONH或NR，R为氢或(C1-4)烷基，Y为(C1-8)烷基或(C1-8)烷氧基(C1-6)烷基，(C1-8)烯基或(C1-8)烯氧基(C1-6)烷基，Ar为苯环，可选择单取代、双取代或三取代，取代基为羟基或卤素，其中X1和X2在彼此的间位或对位，且Z为CO时，AA为天然或非天然的α-氨基酸，n为0或1；或Z为SO2时，AA为可选择取代的乙烯羰基团（由天然或非天然的α-氨基酸通过用甲基烷基替换氮而得到），n为1；制备这些化合物的方法；包含这些化合物的药物组合物和药物组合物；以及它们在治疗与β-淀粉样蛋白生成和/或聚集相关的神经和血管疾病中的用途。
• Electrophilically-induced cyclodestannylation reactions
  作者：Donald J. Peterson、M.Dwight Robbins、John R. Hansen

  DOI：10.1016/s0022-328x(00)85640-5

  日期：1974.7

  alk-3-en-1-yltin compounds to form electron deficient carbon atoms γ to tin. These incipient carbonium ions the electrophilically induce heterolytic fragmentations of the carbon-tin σ bonds (electrophilic displacement of R3Sn+) with concurrent ring formation. Cyclopropylmethoxy derivatives were similarly obtained from thermal and Lewis acid catalyzed cyclodestannylation reactions of 3,4-epoxybutyltri-n-butyltin.

  通过烷基-3-烯丙基锡化合物的环去锡烷基化反应，已经制备了各种环丙基羰基化合物。认为环脱锡反应的初始阶段包括将亲电子试剂加到alk-3-en-1-yltin化合物的双键上，从而形成锡的电子不足的碳原子γ。这些初期的碳离子通过亲电方式诱导碳-锡σ键的杂溶裂解（R 3 Sn +的亲电置换）并同时形成环。环丙基甲氧基衍生物类似地从3，4-环氧丁基三正丁基锡的热和路易斯酸催化的环脱锡反应中获得。
• Alkyltin cyclopropylcarbinylsulfonate
  申请人：The Procter & Gamble Company

  公开号：US03959324A1

  公开（公告）日：1976-05-25

  Pesticidal and anti-inflammatory cyclopropyl compounds, cyclopropyl intermediates for the preparation of pesticidal compounds, especially chrysanthemic acid-like intermediates, and a process for preparing same.

  杀虫和抗炎的环丙基化合物，用于制备杀虫化合物的环丙基中间体，特别是菊酯酸类似物的中间体，以及其制备方法。
• Reactions of homoallylstannanes with carbon electrophiles: stereoselective cyclopropylmethylation based on the γ-effect of tin
  作者：Masanobu Sugawara、Jun-ichi Yoshida

  DOI：10.1039/a900228f

  日期：——

  Homoallylstannanes reacted with carbon electrophiles such as acetals, acid chlorides and aldehydes in the presence of Lewis acids to give the cyclopropylmethylated products with high stereoselectivities.

  同戊基锡在路易斯酸的存在下与醛类、酸氯和醛等碳电ophile反应，生成具有高立体选择性的环丙基甲基化产物。