ethyl 2-(1-butylsulfonyl)acetate | 66102-14-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: ethyl 2-(1-butylsulfonyl)acetate
• 英文别名: ethyl 2-(butylsulfonyl)acetate；(butane-1-sulfonyl)-acetic acid ethyl ester；(Butan-1-sulfonyl)-essigsaeure-aethylester；Aethyl-tert.-butylsulfonylacetat；Aethyl-n-butylsulfonylacetat；Ethyl 2-butylsulfonylacetate
• CAS: 66102-14-5
• 化学式: C₈H₁₆O₄S
• 分子量: 208.279
• InChiKey: FVUNMBHVFQQLBD-UHFFFAOYSA-N

物化性质

• 沸点：
  170-175 °C(Press: 15 Torr)
• 密度：
  1.1184 g/cm3(Temp: 27 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-(1-butylsulfonyl)acetate 在 aqueous alkali 作用下， 生成 n-butylsulfonylacetic acid
  参考文献：
  名称：

  Shainyan, B. A.; Mirskova, A. N., Journal of Organic Chemistry USSR (English Translation), 1980, p. 1518 - 1523

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl butylthioacetate 在 双氧水 作用下， 以 乙酸酐 、 溶剂黄146 为溶剂， 生成 ethyl 2-(1-butylsulfonyl)acetate
  参考文献：
  名称：

  van Leusen,A.M.; Strating,J., Recueil des Travaux Chimiques des Pays-Bas, 1965, vol. 84, p. 140 - 150

  摘要：

  DOI：

文献信息

• Efficient synthesis of aliphatic sulfones by Mg mediated coupling reactions of sulfonyl chlorides and aliphatic halides
  作者：Ying Fu、Qin-Shan Xu、Quan-Zhou Li、Zhengyin Du、Ke-Hu Wang、Danfeng Huang、Yulai Hu

  DOI：10.1039/c7ob00251c

  日期：——

  Sulfonyl chlorides were reduced to anhydrous sulfinate salts with magnesium under sonication. These sulfinates were alkylated to sulfones with alkyl chlorides in the presence of catalytic sodium iodide under sonication. A variety of aliphatic sulfones was efficiently prepared by this one-pot two-step procedure.

  在超声处理下，磺酰氯与镁还原为无水亚磺酸盐。在催化的碘化钠存在下，在超声处理下，用烷基氯将这些亚磺酸盐烷基化为砜。通过这一一锅两步程序，可以有效地制备各种脂肪族砜。
• Design and synthesis of stable α-diazo-β-oxo sulfoxides
  作者：Stuart G. Collins、Orlagh C. M. O'Sullivan、Patrick G. Kelleher、Anita R. Maguire

  DOI：10.1039/c3ob27061k

  日期：——

  Diazo transfer adjacent to a sulfoxide moiety to provide stable, isolable α-diazo-β-oxo sulfoxides has been achieved. Use of monocyclic and bicyclic sulfoxide precursors is critical in enabling isolation of stable derivatives, through introduction of conformational constraint, while acyclic α-diazo-β-oxo sulfoxides are too labile to isolate and characterize.

  已经实现了与亚砜部分相邻的重氮转移，以提供稳定的，可分离的α-重氮-β-氧代亚砜。使用单环和双环亚砜前体对于通过引入构象约束条件分离稳定的衍生物至关重要，而无环α-重氮-β-氧代亚砜过于不稳定，无法分离和表征。
• New 1,3-dithiol-2-ylidene-alkylsulfonylacetates and their uses
  申请人：HOKKO CHEMICAL INDUSTRY CO., LTD

  公开号：EP0242061A2

  公开（公告）日：1987-10-21

  As new compounds are provided alkyl 1,3-dithiol-2-ylidene- alkylsulfonylacetates which are useful as fungicidal agents and agents for therapeutically treating or preventing a liver disorder as well as agents for reducing the internal fat deposit or preventing excessive accumulation of the internal fat deposit in the body of animals, including humans. These new compounds have improved activities for these applications, as compared to known similar compounds.

  作为新化合物，1,3-二硫醇-2-亚基-烷基磺酰基乙酸烷基酯可用作杀真菌剂、治疗或预防肝脏疾病的药物以及减少动物（包括人类）体内脂肪沉积或防止体内脂肪沉积过度积累的药物。与已知的类似化合物相比，这些新化合物在这些应用方面具有更好的活性。
• Mirskova, A.N.; Kryukova, Yu.I.; Levkovskaya, G.G., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, # 3, p. 545 - 550
  作者：Mirskova, A.N.、Kryukova, Yu.I.、Levkovskaya, G.G.、Guseva, S.A.、Voronkov, M.G.

  DOI：——

  日期：——
• Bu₄NI-Catalyzed Cross-Coupling between Sulfonyl Hydrazides and Diazo Compounds To Construct β-Carbonyl Sulfones Using Molecular Oxygen
  作者：Yaxiong Wang、Liang Ma、Meihua Ma、Hao Zheng、Ying Shao、Xiaobing Wan

  DOI：10.1021/acs.orglett.6b02532

  日期：2016.10.7

  A new cross-coupling reaction between sulfonyl hydrazides and diazo compounds has been established, leading to a variety of beta-carbonyl sulfones in good yields. This methodology was distinguished by simple manipulation, easily available starting materials, and wide substrate scope. A plausible mechanism involving a radical process was proposed based upon the experimental observations and literature.