HS-1141

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并异恶唑
• 英文名称: HS-1141
• 英文别名: N,N-diisopropyl-4-[4-(3-aminobenzo[d]isoxazol-6-yloxy)butoxy]-3-methoxybenzamide；4-[4-(3-Amino-benzo[d]isoxazol-6-yloxy)-butoxy]-N,N-diisopropyl-3-methoxy-benzamide；4-[4-[(3-amino-1,2-benzoxazol-6-yl)oxy]butoxy]-3-methoxy-N,N-di(propan-2-yl)benzamide
• 化学式: C₂₅H₃₃N₃O₅
• 分子量: 455.554
• InChiKey: WSFOBNFSFIDIJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  香草酸 在 盐酸 、 氯化亚砜 、 potassium tert-butylate 、 sodium hydride 、 potassium carbonate 、 sodium iodide 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 、 丙酮 、 乙腈 为溶剂， 生成 HS-1141
  参考文献：
  名称：

  3-Amino-1,2-benzisoxazoles: A new family of potent inhibitors of LTB4 binding to the human neutrophils

  摘要：

  A new family of 3-amino-1,2-benzisoxazoles was designed and synthesized to be a potent inhibitors of LTB(4) binding to the human neutrophils. HS-1141 appears to be one of the strongest inhibitors of LTB(4) binding reported so far (IC50 = 7nM). (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00025-5

文献信息

• 3-AMINO-1,2-BENZOISOXAZOLE DERIVATIVES, PROCESS FOR PREPARATION, AND USE THEREOF
  申请人：DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD.

  公开号：EP1019384A1

  公开（公告）日：2000-07-19
• USE OF 4- (4-THIAZOLYL)PHENOXL ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS
  申请人：Dong Wha Pharmaceutical Co., Ltd.

  公开号：EP1411935B1

  公开（公告）日：2010-05-19
• USE OF 4-[(4-THIAZOLYL)PHENOXY]ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS
  申请人：SUH Hong-Suk

  公开号：US20100120875A1

  公开（公告）日：2010-05-13

  A method of treating osteoporosis comprising administering to a subject a composition comprising a compound, 4-5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine or a salt thereof, is described. A method of inhibiting osteoclast activity and stimulating osteoblast activity in a subject also is described.
• USE OF 4-[(4- THIAZOLYL)PHENOXY]ALKOXY-BENZAMIDINE DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF OSTEOPOROSIS
  申请人：SUH Hong-Suk

  公开号：US20100160394A1

  公开（公告）日：2010-06-24

  This invention relates to a pharmaceutical composition containing 4-[(4-thiazolyl)phenoxyl]alkoxy-benzamidine derivatives expressed by the following formula 1 for the prophylaxis and treatment of osteoporosis and more particularly, to the use of 4-5-[4-(5-isoproply-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine or N-hydroxy-4-5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine expressed by the following formula 1 as a pharmaceutical composition for the prophylaxis and treatment of osteoporosis.
• US6150390A
  申请人：——

  公开号：US6150390A

  公开（公告）日：2000-11-21