3,6,9,12,15,18-hexaaza-eicosanediyldiamine | 4617-43-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,6,9,12,15,18-hexaaza-eicosanediyldiamine
• 英文别名: 3,6,9,12,15,18-Hexaaza-eicosandiyldiamin；heptaethyleneoctamine；N'-[2-[2-[2-[2-[2-(2-aminoethylamino)ethylamino]ethylamino]ethylamino]ethylamino]ethyl]ethane-1,2-diamine
• CAS: 4617-43-0
• 化学式: C₁₄H₃₈N₈
• 分子量: 318.509
• InChiKey: IMENJLNZKOMSMC-UHFFFAOYSA-N

物化性质

• 沸点：
  109-110 °C(Press: 0.5 Torr)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  22
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  124
• 氢给体数：
  8
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,2-二溴乙烷 、 三乙烯四胺 在 乙醇 作用下， 生成 3,6,9,12,15,18-hexaaza-eicosanediyldiamine
  参考文献：
  名称：

  Jones et al., Journal of Organic Chemistry, 1944, vol. 9, p. 137

  摘要：

  DOI：

文献信息

• METHOD FOR SELECTIVELY SYNTHESIZING CATIONIC LIPIDS
  申请人：Samyang Biopharmaceuticals Corporation

  公开号：US20180346410A1

  公开（公告）日：2018-12-06

  Disclosed is a method capable of selectively synthesizing cationic lipids by controlling the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of reaction conditions.

  本方法揭示了一种能够通过控制脂肪酸基团相对于寡聚烯胺的引入速率来选择性合成阳离子脂质的方法，通过改变反应条件实现。
• FUNCTIONALIZED HIGHLY BRANCHED MELAMINE-POLYAMINE POLYMERS
  申请人：Peretolchin Maxim

  公开号：US20120252987A1

  公开（公告）日：2012-10-04

  The present invention relates to a method for producing amphiphilic functionalized highly branched melamine-polyamine polymers by condensing melamine and optionally a melamine derivate having at least one different amine having at least two primary amino groups and optionally also with urea and/or at least one urea derivative and/or with at least one at least difunctional diisocyanate or polyisocyanate and/or at least one carbolic acid having at least two carboxyl groups or at least one derivative thereof, optionally quaternizing a portion of the amino groups of the polymer thereby obtained, reacting the polymer thus obtained with at least one compound capable of undergoing a condensation or addition reaction with amino groups, and optionally quaternizing at least part of the amino groups of the polymer obtained in the first step. The invention further relates to the amphiphilic functionalized highly branched melamine-polyamine polymers that can be obtained by the method according to the invention, and to the use thereof as surface active agents.

  本发明涉及一种通过将三聚氰胺和至少一种具有至少两个主要氨基的不同氨基的三聚氰胺衍生物以及可能还包括尿素和/或至少一种尿素衍生物和/或至少一种至少双官能团二异氰酸酯或多异氰酸酯和/或至少一种至少具有两个羧基的羧酸或其衍生物缩合，从而制备含有两性功能化的高支化三聚氰胺-多胺聚合物的方法。可选地，对所获得的聚合物的部分氨基进行季铵化，然后将所获得的聚合物与至少一种能够与氨基发生缩合或加成反应的化合物反应，并可选地对第一步中获得的聚合物的部分氨基进行季铵化。本发明还涉及通过本发明的方法可以获得的含有两性功能化的高支化三聚氰胺-多胺聚合物，以及将其用作表面活性剂的用途。
• [EN] METHOD FOR PREPARING TERTIARY AMINES COMPRISING ETHYNYLBENZYL SUBSTITUENTS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'AMINES TERTIAIRES COMPRENANT DES SUBSTITUANTS ÉTHYNYLBENZYLE
  申请人：SIBUR HOLDING PUBLIC JOINT STOCK CO

  公开号：WO2017116272A1

  公开（公告）日：2017-07-06

  The invention relates to the field of the organic chemistry and, in particular to a method for preparing a compound of formula (I) or (II), and/or a mixture of isomers thereof, wherein R is -Alk, -AlkN(Alk)2, -AlkN(Ar)2, -AlkNAlkAr, -AlkOH, -AlkOAlk, -AlkOAr, -AlkSAlk, -AlkSAr, or -Ar; R1, R2, R3, and R4 are independently -Alk, -Hal, - OH, -OAlk, -OAr, -SAlk, -SAr, or -NR2, wherein R is -Alk, - AlkN(Alk)2, -AlkN(Ar)2, -AlkNAlkAr, -AlkOH, -AlkOAlk, -AlkOAr, -AlkSAlk, -AlkSAr, or -Ar, wherein Alk is C1- C16alkyl, C3-C16cycloalkyl, C2-C16alkenyl, C2-C16alkynyl; Ar is phenyl; Hal is halogen selected from -Cl, -Br, and -I,

  该发明涉及有机化学领域，特别是一种制备化合物的方法，该化合物的化学式为(I)或(II)，和/或其异构体混合物，其中R为-Alk，-AlkN(Alk)2，-AlkN(Ar)2，-AlkNAlkAr，-AlkOH，-AlkOAlk，-AlkOAr，-AlkSAlk，-AlkSAr或-Ar；R1、R2、R3和R4独立地为-Alk、-Hal、-OH、-OAlk、-OAr、-SAlk、-SAr或-NR2，其中R为-Alk、-AlkN(Alk)2、-AlkN(Ar)2、-AlkNAlkAr、-AlkOH、-AlkOAlk、-AlkOAr、-AlkSAlk、-AlkSAr或-Ar，其中Alk为C1-C16烷基，C3-C16环烷基，C2-C16烯基，C2-C16炔基；Ar为苯基；Hal为从-Cl，-Br和-I中选择的卤素。
• Method for producing cyclic carbamate ester
  申请人：Ikemoto Kazuto

  公开号：US20050154200A1

  公开（公告）日：2005-07-14

  A method for producing a cyclic carbamate ester produces the cyclic carbamate ester by reacting an organic compound having at least two halogen atoms per molecule, an amine having at least two hydrogen atoms on a nitrogen atom, and carbon dioxide.

  一种生产环状碳酸酯的方法，通过将每个分子至少具有两个卤原子的有机化合物，至少具有一个氮原子上的两个氢原子的胺和二氧化碳反应来产生环状碳酸酯。
• CARRIER FOR NEGATIVELY CHARGED DRUGS COMPRISING A CATIONIC LIPID AND A PREPARATION METHOD THEREOF
  申请人：Choi Sung-Won

  公开号：US20130266641A1

  公开（公告）日：2013-10-10

  Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase the in vivo stability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.

  本发明公开了一种用于传递负电药物的载体，包括由公式1表示的阳离子脂质以及其制备方法。还公开了一种药物组合物，包括由公式1表示的阳离子脂质和负电药物，其中负电药物与阳离子脂质形成复合物。该组合物可以增加局部或全身给药后负电药物的体内稳定性，并允许负电药物的细胞内传递。因此，该组合物对于提高负电药物的治疗效果将是有用的。