1-((2R,3R,4R,5R)-3-fluoro-5-(hydroxymethyl)-4-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 1445384-26-8
中文名称
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中文别名
——
英文名称
1-((2R,3R,4R,5R)-3-fluoro-5-(hydroxymethyl)-4-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
英文别名
——
CAS
1445384-26-8
化学式
C29H27FN2O6
mdl
——
分子量
518.542
InChiKey
SXIOLRAAAIHOPR-MIRJVGOZSA-N
BEILSTEIN
——
EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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密度：1.38±0.1 g/cm3(Predicted)
计算性质
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辛醇/水分配系数(LogP)：3.15
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重原子数：38.0
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可旋转键数：8.0
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环数：5.0
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sp3杂化的碳原子比例：0.24
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拓扑面积：102.78
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氢给体数：2.0
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氢受体数：7.0
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 2'-氟-2'-脱氧尿苷 2'-deoxy-2'-fluorouridine 784-71-4 C9H11FN2O5 246.195 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 1-((2R,3R,4R)-3-fluoro-5,5-bis(hydroxymethyl)-4-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445384-29-1 C30H29FN2O7 548.568 —— 1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-5-(hydroxymethyl)-4-[(4-methoxyphenyl)-diphenylmethoxy]oxolan-2-yl]pyrimidine-2,4-dione 1445384-35-9 C30H28ClFN2O6 567.014 —— 1-((2R,3R,4R,5R)-5-(bromomethyl)-3-fluoro-5-(hydroxymethyl)-4-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445389-11-6 C30H28BrFN2O6 611.465 —— 1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445389-64-9 C50H44ClFN2O7 839.36 —— 1-((2R,3R,4R,5R)-5-(bromomethyl)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445389-01-4 C50H44BrFN2O7 883.811 —— 1-((2R,3R,4R,5R)-3-fluoro-5-(hydroxymethyl)-4-((4-methoxyphenyl)diphenylmethoxy)-5-((methylthio)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445388-71-5 C31H31FN2O6S 578.661 —— ((3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2,2-diyl)bis(methylene) bis(trifluoromethanesulfonate) 1445384-32-6 C32H27F7N2O11S2 812.694 —— 1-((2R,3R,4R,5R)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-((methylthio)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445388-76-0 C51H47FN2O7S 851.008 —— 1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-5-(hydroxymethyl)-4-[(4-methoxyphenyl)diphenylmethoxy]oxolan-2-yl]-5-methyl-3H-pyrimidine-2,4-dione 1445389-26-3 C31H30ClFN2O6 581.04 —— 1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 1445389-31-0 C51H46ClFN2O7 853.387 —— 1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-5-(hydroxymethyl)-4-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione 1445389-21-8 C31H30ClFN2O7 597.04 —— 1-((2R,3R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445384-38-2 C36H42ClFN2O6Si 681.276 —— 1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2-yl)-4-(methylamino)pyrimidin-2(1H)-one 1445389-69-4 C51H47ClFN3O6 852.402 —— 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-((methylthio)methyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445388-81-7 C51H48FN3O6S 850.023 —— 4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one 1445389-36-5 C51H47ClFN3O6 852.402 —— 4-amino-1-((2R,3R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluoro-4-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445387-86-9 C36H43ClFN3O5Si 680.291 —— [(2R,3R,4R,5R)-3-benzoyloxy-2-(chloromethyl)-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-2-yl]methyl benzoate 1445389-50-3 C24H20ClFN2O7 502.883 —— 4-((bis(4-methoxyphenyl)(phenyl)methyl)amino)-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-5-(hydroxymethyl)-4-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445384-41-7 C51H47ClFN3O7 868.401 —— (2S,3R,4R,5R)-5-(4-((bis(4-methoxyphenyl)(phenyl)methyl)amino)-2-oxopyrimidin-1(2H)-yl)-2-(chloromethyl)-4-fluoro-3-((4-methoxyphenyl)diphenylmethoxy)tetrahydrofuran-2-carbaldehyde 1445384-44-0 C51H45ClFN3O7 866.386 —— (6R,7R,8R,9R)-9-(bromomethyl)-7-fluoro-8-((4-methoxyphenyl)diphenylmethoxy)-7,8,9,10-tetrahydro-2H,6H-6,9-epoxypyrimido[2,1-b][1,3]oxazocin-2-one 1445388-96-4 C30H26BrFN2O5 593.449 —— (6R,7R,8R,9R)-9-(chloromethyl)-7-fluoro-8-((4-methoxyphenyl)diphenylmethoxy)-7,8,9,10-tetrahydro-2H,6H-6,9-epoxypyrimido[2,1-b][1,3]oxazocin-2-one 1445387-76-7 C30H26ClFN2O5 548.998 —— ((6R,7R,8R,9S)-7-fluoro-8-((4-methoxyphenyl)diphenylmethoxy)-2-oxo-7,8-dihydro-2H,6H-6,9-epoxypyrimido[2,1-b][1,3]oxazocin-9(10H)-yl)methyl trifluoromethanesulfonate 1445388-66-8 C31H26F4N2O8S 662.616 —— [(2R,3R,4R,5R)-3-acetyloxy-2-(chloromethyl)-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-2-yl]methyl acetate 1445390-24-8 C14H16ClFN2O7 378.742 —— ALS-8112 1445379-94-1 C10H12ClFN2O5 294.667 —— (2R,3R,4R,5R)-2-(chloromethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((isobutyryloxy)methyl)tetrahydrofuran-3-yl isobutyrate 1445388-91-9 C18H24ClFN2O7 434.849 —— [(2R,3R,4R,5R)-3-ben