9-甲基-9-氮杂双环[3.3.1]壬烷 | 491-25-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 9-甲基-9-氮杂双环[3.3.1]壬烷
• 英文名称: 9-methyl-9-aza-bicyclo[3.3.1]nonane
• 英文别名: 9-Methyl-9-azabicyclo<3.3.1>nonan；N-Methylgranatanin；9-methyl-9-azabicyclo<3.3.1>nonane；9-Methyl-9-azabicyclo[3.3.1]nonane
• CAS: 491-25-8
• 化学式: C₉H₁₇N
• 分子量: 139.241
• InChiKey: ODWVFJUVKLPMDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-甲基-9-氮杂双环[3.3.1]壬烷 在 甲醇 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 9-氮杂双环[3.3.1]壬烷盐酸盐
  参考文献：
  名称：

  Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

  摘要：

  A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects or, biological activity, especially in uterine tissue. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.074
• 作为产物：
  描述：

  9-甲基-9-氮杂双环[3.3.1]壬-3-酮 在 一水合肼 作用下， 生成 9-甲基-9-氮杂双环[3.3.1]壬烷
  参考文献：
  名称：

  Unsaturated Amines. XII. Steric Requirements of Mercuric Acetate Oxidation of Tertiary Amines¹

  摘要：

  DOI：

  10.1021/ja01535a031

文献信息

• ORGANO-1-OXA-4-AZONIUM CYCLOHEXANE COMPOUNDS
  申请人：UOP LLC

  公开号：US20160159760A1

  公开（公告）日：2016-06-09

  Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.

  描述了新型的1-oxa-4-azonium环己烷盐。这些化合物可用作结构导向剂，并且克服了与OSDA合成和随后的沸石合成相关许多典型问题。还描述了从各种起始材料合成1-oxa-4-azonium环己烷盐的方法。 将取代的烃加入水中形成混合物，然后加入1-oxa-4-azacyclohexane衍生物。搅拌反应混合物，直到获得含有1-oxa-4-azonium环己烷盐的溶液。
• Chemical Studies on Drug Metabolism II.N-Demethylation andN-Oxidation of Some Alicyclic Amines by Ruthenium Tetroxide
  作者：Roberto Perrone、Giuseppe Carbonara、Vincenzo Tortorella

  DOI：10.1002/ardp.19843170712

  日期：——

  Oxidation with ruthenium tetroxide of alicyclic N‐methylamines such as pempidine (1a), 9‐methyl‐9‐azabicyclo[3.3.1]nonane (2a), and 8‐methyl‐8‐azabicyclo[3.2.1]octane (3a), in which carbon atoms linked to nitrogen are sterically hindered, leads to the N‐formyl and N‐demethylated derivatives. The latter, when further oxidized, give the N‐oxides in good yields.

  用四氧化钌氧化脂环族 N-甲胺，如哌啶 (1a)、9-甲基-9-氮杂双环 [3.3.1] 壬烷 (2a) 和 8-甲基-8-氮杂双环 [3.2.1] 辛烷 (3a) ，其中与氮连接的碳原子受到空间位阻，导致 N-甲酰基和 N-去甲基化衍生物。后者，当进一步氧化时，以良好的产率得到 N-氧化物。
• Cyclic Polyolefins. I. Synthesis of Cycloöctatetraene from Pseudopelletierine¹
  作者：Arthur C. Cope、C. G. Overberger

  DOI：10.1021/ja01184a041

  日期：1948.4

  This paper presents data amplifying our recent communication3 which reported duplication of the Willstatter synthesis of cyclooctatetraene from p~eudopelletierine.'~~ Indirect evidence of three kinds had been interpreted as indicating that the Willstatter product might not have been 1,3,5,7cyclooctatetraene6 : Similarity of the product to styrene ; the fact that catalytic dehydrogenation of cyclooctene

  本文提供的数据放大了我们最近的通讯 3，其中报告了从 p~eudopelletierine 中 Willstatter 合成环辛四烯的重复。 ~~ 三种间接证据被解释为表明 Willstatter 产物可能不是 1,3,5,7 环辛四烯 6 ：产品与苯乙烯的相似性；环辛烯在 425-455' 催化脱氢生成苯乙烯的事实；证明将 Hofmann 彻底甲基化程序应用于二氨基丁烷（在 Willstatter 合成中作为中间体的开链模型进行研究）除共轭 1,3-丁二烯外还产生乙炔和甲基丙二烯。从乙炔催化合成环辛四烯的发展重新引起了人们对碳氢化合物的兴趣。属性中的对应关系 使催化产品和 Willstatter 产品看起来很可能是相同的。现在，通过重复 Willstatter 合成并将产物与由乙炔催化制备的环辛四烯进行直接比较，这已经完全确定。我们的合成开始于从戊二醛、甲胺和丙酮二羧酸中制备假磷灰石 (I)。8
• PROCESS FOR PREPARING FORMIC ACID BY REACTING CARBON DIOXIDE WITH HYDROGEN
  申请人：Schaub Thomas

  公开号：US20120157711A1

  公开（公告）日：2012-06-21

  The present invention relates to a process for preparing formic acid by reacting carbon dioxide ( 1 ) with hydrogen ( 2 ) in a hydrogenation reactor (I) in the presence of a catalyst comprising an element of group 8, 9 or 10 of the Periodic Table, a tertiary amine comprising at least 12 carbon atoms per molecule and a polar solvent comprising one or more monoalcohols selected from among methanol, ethanol, propanols and butanols, to form formic acid/amine adducts as intermediates which are subsequently thermally dissociated, where a tertiary amine having a boiling point which is at least 5° C. higher than that of formic acid is used and a reaction mixture comprising the polar solvent, the formic acid/amine adducts, the tertiary amine and the catalyst is formed in the reaction in the hydrogenation reactor (I) and is discharged from the reactor as output ( 3 ).

  本发明涉及一种制备甲酸的方法，通过在氢化反应器（I）中，在存在一种催化剂，该催化剂包含周期表第8、9或10族元素，一种含有每个分子至少12个碳原子的三级胺和一种极性溶剂，所述极性溶剂包括从甲醇、乙醇、丙醇和丁醇中选择的一种或多种单醇，将二氧化碳（1）与氢气（2）反应，形成甲酸/胺加合物作为中间体，随后进行热解离，其中使用沸点比甲酸高至少5°C的三级胺，反应混合物包括极性溶剂、甲酸/胺加合物、三级胺和催化剂，在氢化反应器（I）中形成，并作为输出（3）从反应器中排出。
• PROCESS FOR PREPARING FORMIC ACID BY REACTION OF CARBON DIOXIDE WITH HYDROGEN
  申请人：Schaub Thomas

  公开号：US20110319658A1

  公开（公告）日：2011-12-29

  A process for preparing formic acid by reaction of carbon dioxide ( 1 ) with hydrogen ( 2 ) in a hydrogenation reactor (I) in the presence of a catalyst comprising an element of group 8, 9 or 10 of the Periodic Table, a tertiary amine comprising at least 12 carbon atoms per molecule and a polar solvent comprising one or more monoalcohols selected from among methanol, ethanol, propanols and butanols and also water, to form formic acid/amine adducts as intermediates which are subsequently thermally dissociated, with work-up of the output ( 3 ) from the hydrogenation reactor (I) in a plurality of process steps, where a tertiary amine-comprising stream ( 13 ) from the work-up is used as selective solvent for the catalyst, is proposed.

  一种制备甲酸的方法，通过在氢化反应器（I）中，在周期表第8、9或10族元素组成的催化剂存在下，将二氧化碳（1）与氢（2）反应，以及包含每个分子至少12个碳原子的三级胺和包括甲醇、乙醇、丙醇和丁醇中的一种或多种单醇以及水的极性溶剂，形成甲酸/胺加合物作为中间体，随后进行热解离，并通过多个工艺步骤处理来自氢化反应器（I）的产物（3），其中工艺步骤中使用来自工艺处理的三级胺组成流（13）作为催化剂的选择性溶剂。

表征谱图