hexahydro-pyrrolizine-1-carboxylic acid ethyl ester | 90978-65-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯里西啶类
• 英文名称: hexahydro-pyrrolizine-1-carboxylic acid ethyl ester
• 英文别名: hexahydropyrrolizine-1-carboxylic acid ethyl ester；Pyrrolyzidin-carbonsaeure-(1)-ethylester；Pyrrolisidin-1-carboonsaeure-ethylester；Pyrrolizidincarbonsaeure-(1)-ethylester；(+/-)-Isoretronecanolsaeure-ethylester；dl-Trachelantamidinsaeure-ethylester；ethyl hexahydro-1H-pyrrolizine-1-carboxylate；ethyl 2,3,5,6,7,8-hexahydro-1H-pyrrolizine-1-carboxylate
• CAS: 90978-65-7
• 化学式: C₁₀H₁₇NO₂
• 分子量: 183.25
• InChiKey: FBZMBOHWVBVEDR-UHFFFAOYSA-N

物化性质

• 沸点：
  240.8±23.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  hexahydro-pyrrolizine-1-carboxylic acid ethyl ester 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 trans-1-Azabicyclo<3.3.0>octan-4-ylmethyl benzoate
  参考文献：
  名称：

  Pandey, Ganesh; Lakshmaiah; Gadre, Smita R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 2, p. 91 - 98

  摘要：

  DOI：
• 作为产物：
  描述：

  Ethyl [1-(2-chloroethyl)pyrrolidin-2-yl]acetate 生成 hexahydro-pyrrolizine-1-carboxylic acid ethyl ester
  参考文献：
  名称：

  KAMEHTANI, TEHTSUDZI;XONDA, TOSIO

  摘要：

  DOI：

文献信息

• A 1,3-dipolar cycloaddition of alicyclic methylene iminium ylide to form pyrrolizidine nuclei and its application to synthesis of pyrrolizidine alkaloids.
  作者：YOSHIYASU TERAO、NOBUYUKI IMAI、KAZUO ACHIWA、MINORU SEKIYA

  DOI：10.1248/cpb.30.3167

  日期：——

  Efficient synthesis of pyrrolizidines and indolizidines has been achieved by reacting tetracyclic hexahydro-1, 3, 5-triazines with olefinic and acetylenic compounds in the presence of trimethylsilylmethyl trifluoromethanesulfonate and cesium fluoride. This reaction was applied to the synthesis of several pyrrolizidine alkaloids, (±)-trachelanthamidine, (±)-supinidine, and (±)-isoretronecanol.

  通过在三甲基硅甲基三氟甲磺酸酯和氟化铯存在下，将四环己烷-1,3,5-三嗪与烯烃和炔烃化合物反应，实现了吡咯并吡嗪和吲哚并吡嗪的高效合成。该反应应用于几种吡咯并吡嗪生物碱的合成，包括（±）-刺桐胺、（±）-苦参碱和（±）-异雷公藤醇。
• ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
  申请人：SCHWINK Lothar

  公开号：US20070197584A1

  公开（公告）日：2007-08-23

  The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description as well as to pharmaceutical compositions and medical treatments employing these compounds.

  该发明涉及公式I的芳基取代的多环胺，特别是双环胺，以及其生理耐受的盐和生理功能衍生物；其中符号和基团在描述中有解释，还涉及使用这些化合物的药物组合物和医疗治疗。
• USE OF ARYL-SUBSTITUTED POLYCYCLIC AMINES AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090258872A1

  公开（公告）日：2009-10-15

  The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description.

  本发明涉及公式I的芳基取代多环胺的治疗用途，特别是双环胺，以及其生理上耐受的盐和生理上功能性衍生物；其中符号和基团在说明中解释。
• Use of aryl-substituted polycyclic amines as medicaments
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：US08163741B2

  公开（公告）日：2012-04-24

  The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description.

  该发明涉及公式I中芳基取代的多环胺的治疗用途，特别是双环胺，以及其生理耐受的盐和生理功能衍生物的使用；其中符号和基团在说明中解释。
• Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：US07569583B2

  公开（公告）日：2009-08-04

  The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description as well as to pharmaceutical compositions and medical treatments employing these compounds.

  本发明涉及公式I的芳基取代的多环胺，特别是双环胺，以及其生理耐受的盐和生理功能衍生物；其中符号和基团在说明中解释，以及使用这些化合物的药物组合物和医疗治疗。