N-乙酰基-L-丙氨酰-L-酪氨酸 | 90021-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 中文名称: N-乙酰基-L-丙氨酰-L-酪氨酸
• 中文别名: 环丙烷甲醛，2-环己基-，(1R，2S)-rel-(9CI)
• 英文名称: 3,6-anhydro-D-glucono-1,4-lactone
• 英文别名: 3,6-anhydro-D-gluconic acid-4-lactone；3,6-Anhydro-D-gluconsaeure-4-lacton；3,6-Anhydro-gluconsaeure-4-lacton；(3R,3aR,6R,6aR)-3,6-dihydroxy-3,3a,6,6a-tetrahydro-2H-furo[3,2-b]furan-5-one
• CAS: 90021-48-0
• 化学式: C₆H₈O₅
• 分子量: 160.127
• InChiKey: PTAYTAIUBPJLNO-TXICZTDVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-乙酰基-L-丙氨酰-L-酪氨酸 在 甲醇 、 氨 作用下， 生成 (R)-((2S)-3c,4c-dihydroxy-tetrahydro-[2r]furyl)-hydroxy-acetic acid amide
  参考文献：
  名称：

  Haworth et al., Journal of the Chemical Society, 1941, p. 88,97

  摘要：

  DOI：
• 作为产物：
  描述：

  3,6-脱水-D-葡萄糖 在 溴 作用下， 生成 N-乙酰基-L-丙氨酰-L-酪氨酸
  参考文献：
  名称：

  Fischer,E.; Zach, Chemische Berichte, 1912, vol. 45, p. 2072

  摘要：

  DOI：

文献信息

• [EN] MICROWAVE ASSISTED SYNTHESIS OF DEHYDRATED SUGAR DERIVATIVES HYDROXYMETHYLFURFURAL, LEVULINIC ACID, ANHYDROSUGAR ALCOHOLS, AND ETHERS THEREOF<br/>[FR] SYNTHÈSE ASSISTÉE PAR RAYONNEMENT MICROONDES DES DÉRIVÉS DE SUCRES DÉSHYDRATÉS HYDROXYMÉTHYLFURFURAL, ACIDE LÉVULINIQUE, ALCOOLS DE SUCRE ANHYDRES ET LEURS ÉTHERS
  申请人：ARCHER DANIELS MIDLAND CO

  公开号：WO2012015616A1

  公开（公告）日：2012-02-02

  Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210C, and typical reaction times are 30 minutes or less.

  本文描述了使用微波辐射（MW）制备脱水糖和脱水糖衍生物的方法，以及纯化它们的方法。脱水糖衍生物包括5-羟甲基-2-呋喃甲醛（HMF）和无水糖醇，如山梨醇和异山梨醇。衍生物包括HMF醚、左旋糖酸酯和无水糖醇的醚衍生物。所述方法需要比已知的非微波介导反应更低的反应温度和更短的反应时间。典型反应条件为120-210℃，典型反应时间为30分钟或更短。
• MICROWAVE ASSISTED SYNTHESIS OF DEHYDRATED SUGAR DERIVATIVES HYDROXYMETHYLFURFURAL, LEVULINIC ACID, ANHYDROSUGAR ALCOHOLS, AND ETHERS THEREOF
  申请人：Howard Stephen J.

  公开号：US20130123520A1

  公开（公告）日：2013-05-16

  Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210° C., and typical reaction times are 30 minutes or less.

  本文介绍了使用微波辐射(MW)制备脱水糖和脱水糖衍生物的方法，以及纯化这些物质的方法。脱水糖衍生物包括5-羟甲基-2-呋喃甲醛(HMF)和无水糖醇如山梨醇和异山梨醇。衍生物包括HMF醚、左旋糖酸酯和无水糖醇的醚衍生物。所述方法需要比已知的非微波介导反应更低的反应温度和更短的反应时间。典型的反应条件为120-210℃，典型的反应时间为30分钟或更短。
• Acyloxonium ions in the high-yielding synthesis of oxolanes from alditols, hexoses, and hexonolactones catalysed by car☐ylic acids in anhydrous hydrogen fluoride
  作者：Jacques Defaye、Andre´e Gadelle、Christian Pedersen

  DOI：10.1016/0008-6215(90)80139-t

  日期：1990.9
• The direct synthesis of 6-amino-6-deoxyaldonic acids as monomers for the preparation of polyhydroxylated nylon 6
  作者：Ludovic Chaveriat、Imane Stasik、Gilles Demailly、Daniel Beaupère

  DOI：10.1016/j.tetasy.2006.04.018

  日期：2006.5

  6-Azido-6-deoxy-D-galactitol and D-mannitol were obtained quantitatively via the reduction of the corresponding 6-azido-6deoxy-D-hexono-1,4-lactones, and 6-azido-6-deoxy-D-glucitol was obtained by the reduction of 6-azido-6-deoxyglucose in good yields. The reduction of monoazidodeoxyhexitols by catalytic hydrogenation gave the monoaminohexitol analogues in 95-98% yields. Oxidation of these afforded the corresponding 6-amino-6-deoxy-D-aldonic acids in moderate yields. Alternatively, saponification of 6-azido-6-deoxy-D-hexonolactones gave 6-azido-6-deoxyaldonic acid salts which, after reduction followed by neutralization, led to the expected compounds in 82-88% overall yields. (c) 2006 Elsevier Ltd. All rights reserved.
• DEFAYE, JACQUES;GADELLE, ANDREE;PEDERSEN, CHRISTIAN, CARBOHYDR. RES., 205,(1990) C. 191-202
  作者：DEFAYE, JACQUES、GADELLE, ANDREE、PEDERSEN, CHRISTIAN

  DOI：——

  日期：——