3,5-Di-chloroacetoxy-4-isopropyl-trans-stilbene | 344396-15-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3,5-Di-chloroacetoxy-4-isopropyl-trans-stilbene
• 英文别名: [3-(2-chloroacetyl)oxy-5-[(E)-2-phenylethenyl]-2-propan-2-ylphenyl] 2-chloroacetate
• CAS: 344396-15-2
• 化学式: C₂₁H₂₀Cl₂O₄
• 分子量: 407.293
• InChiKey: XVILJZAZIIZHHO-CMDGGOBGSA-N

物化性质

• 沸点：
  500.0±50.0 °C(Predicted)
• 密度：
  1.269±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-3,5-二羟基-4-异丙基二苯乙烯 、 氯乙酸酐 在 三乙胺 作用下， 生成 3,5-Di-chloroacetoxy-4-isopropyl-trans-stilbene
  参考文献：
  名称：

  Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues

  摘要：

  本发明提供了新颖的二苯乙烯化合物及其药用可接受的盐。还提供了制备本发明化合物的方法，以及在免疫、炎症和自身免疫疾病治疗中使用这些化合物的方法。

  公开号：

  US20050059733A1

文献信息

• Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxyltilbenes and novel stilbene derivatives and analogues
  申请人：——

  公开号：US20030171429A1

  公开（公告）日：2003-09-11

  Disclosed herein are compositions containing hydroxylstilbenes or their derivatives or analogues. The compositions are useful to inhibit protein kinease, and for the treatment of inflammatory diseases, including psoriasis, multiple sclerosis, rhumatoid arthritis, restinosis, inflammatory bowel disease, and inflammatory lung disease. They are also useful to treat surgical adhesions and graft rejection. Novel derivatives and analogues are also disclosed.

  本文揭示了含有羟基苯乙烯或其衍生物或类似物的组合物。这些组合物可用于抑制蛋白激酶，并用于治疗炎症性疾病，包括牛皮癣、多发性硬化症、类风湿性关节炎、再狭窄、炎症性肠病和炎症性肺病。它们还可用于治疗手术粘连和移植排斥。本文还揭示了新的衍生物和类似物。
• Anti-Inflammatory and Psoriasis Treatment and Protein Kinase Inhibition by Hydroxy Stilbenes and Novel Stilbene Derivatives and Analogues
  申请人：Chen Genhui

  公开号：US20080139666A1

  公开（公告）日：2008-06-12

  The present invention provides novel methods of treating psoriasis, protein tyrosine kinase-associated disorders, inflammation, epidermal hyperproliferation, diabetes, immune and autoimmune diseases, eczema, and inflammatory bowel disease, inhibiting protein kinase, neutrophil activation, cell proliferation, tumour growth, metastasis, and the development of atheromatous plaque and restonosis, controlling angiogenesis, and preventing inflammatory bowel disease, using hydroxystilbenes and novel stilbene derivatives.

  本发明提供了使用羟基芝芝醇和新型芝芝醇衍生物来治疗银屑病、蛋白酪氨酸激酶相关疾病、炎症、表皮过度增生、糖尿病、免疫和自身免疫性疾病、湿疹和炎症性肠病，抑制蛋白激酶、中性粒细胞活化、细胞增殖、肿瘤生长、转移和动脉粥样硬化斑块和再狭窄的发展，控制血管生成和预防炎症性肠病的新方法。
• Anti-Inflammatory and Psoriasis Treatment and Protein Kinase Inhibition by Hydroxystilbenes and Novel Stilbene Derivatives and Analogues
  申请人：Chen Genhui

  公开号：US20080255245A1

  公开（公告）日：2008-10-16

  The present invention provides novel diphenyl ethene compounds and pharmaceutically-acceptable salts thereof. Also provided are methods for making the compounds of the invention as well as methods for the use thereof in the treatment of immune, inflammatory, and auto-immune diseases.

  本发明提供了新型的二苯乙烯化合物及其药用盐。还提供了制备本发明化合物的方法以及在治疗免疫、炎症和自身免疫性疾病中使用它们的方法。
• ANTI-INFLAMMATORY AND PSORIASIS TREATMENT AND PROTEIN KINASE INHIBITION BY HYDROXY STILBENES AND NOVEL STILBENE DERIVATIVES AND ANALOGUES
  申请人：Chen Genhui

  公开号：US20100094041A1

  公开（公告）日：2010-04-15

  The present invention provides pharmaceutical compositions containing hydroxystilbenes or their derivatives or analogues. The pharmaceutical compositions are useful for protein kinase inhibition, and for treatment of psoriasis, eczema and inflammation.

  本发明提供含有羟基芪类或其衍生物或类似物的制药组合物。该制药组合物可用于蛋白激酶抑制和治疗牛皮癣、湿疹和炎症。
• POLYHYDROXYSTILBENES AND STILBENE OXIDES AS ANTIPSORIATIC AGENTS AND PROTEIN KINASE INHIBITORS
  申请人：Welichem Biotech Inc.

  公开号：EP1248774B1

  公开（公告）日：2009-10-07