2-O-monoethylisosorbide | 1054798-97-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: 2-O-monoethylisosorbide
• 英文别名: ethylisosorbide；(3R,3aR,6S,6aR)-6-ethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol
• CAS: 1054798-97-8
• 化学式: C₈H₁₄O₄
• 分子量: 174.197
• InChiKey: XTYOEVMXPKXCCN-ULAWRXDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙醇 、 异山梨醇 在 dodecatungstosilic acid 作用下， 以 甲苯 为溶剂， 反应 0.17h， 以5.2%的产率得到2-O-monoethylisosorbide
  参考文献：
  名称：

  Hydrogen bond distinction and activation upon catalytic etherification of hydroxyl compounds

  摘要：

  ln δ与1/T之间的线性相关性的斜率（A）可以区分分子内和分子间氢键，并预测它们的反应性。

  DOI：

  10.1039/c4cc08467e

文献信息

• [EN] SYNTHESIS OF ISOHEXIDE ETHERS AND CARBONATES<br/>[FR] SYNTHÈSE D'ÉTHERS ET DE CARBONATES D'ISOHEXIDE
  申请人：ARCHER DANIELS MIDLAND CO

  公开号：WO2015094716A1

  公开（公告）日：2015-06-25

  A facile, straightforward method for alkylation of anhydrosugar alcohols (isohexides) using a carbonate reagent is described. The alkylation method involves: a) contacting in a solution of an isohexide with a dialkyl, diallyl, or diaryl carbonate, and the solution includes a Brnsted base; and b) producing either an alkyl ether or alkyl carbonate of the isohexide compound. The alkylation reaction is in situ, that is, performed without an extrinsic catalyst. According to the method, one can synthesize various ethers and carbonates.

  这是一种简单、直接的方法，用碳酸盐试剂对无水糖醇（异己六糖）进行烷基化。烷基化方法包括：a）将异己六糖在含有Brnsted碱的溶液中与二烷基、二烯丙基或二芳基碳酸酯接触；b）产生异己六糖化合物的烷基醚或烷基碳酸酯。烷基化反应是原位的，即在没有外部催化剂的情况下进行。根据该方法，可以合成各种醚和碳酸酯。
• Method for preparing dialkyloxydianhyrohexitol by etherification of dianhydrohexitol using a light alcohol, in the presence of an acidic catalyst
  申请人：ROQUETTE FRERES

  公开号：US09321783B2

  公开（公告）日：2016-04-26

  A method for preparing a dialkyloxydianhyrohexitol (dimethylisosorbide) composition by etherification of dianhydrohexitol (isosorbide). The aim is to achieve a “clean” method that avoids the use of a methylation agent such as dimethyl sulfate or methyl chloride, which generates stoechiometric quantities of salts, or expensive dialkyl-carbonates, wherein only one of the two methyl groups participates in the preparation of mixed isosorbide ethers. The method involves using at least one O-alkylation agent and a catalyst including an acid or an acid salt, preferably a catalyst having Lewis or BrØnsted acid properties. A device for carrying out the method wherein the device includes a vaporization oven and a reaction oven is also described.

  一种制备二烷氧基二环己基醇（二甲基异山梨醇）组合物的方法，通过对二环己基醇（山梨醇）进行醚化反应来实现。该方法的目的是实现一种“清洁”方法，避免使用甲基化剂如二甲基硫酸酯或氯甲烷，这些甲基化剂会产生化学计量的盐或昂贵的双烷基碳酸酯，其中只有其中一个甲基参与混合异山梨醇醚的制备。该方法涉及使用至少一种O-烷基化剂和一个催化剂，包括酸或酸盐，优选具有Lewis或BrØnsted酸性能的催化剂。还描述了一种用于执行该方法的装置，其中该装置包括一个蒸发炉和一个反应炉。
• Oral hygiene composition
  申请人：ICI AMERICAS INC.

  公开号：EP0186276A2

  公开（公告）日：1986-07-02

  Oral hygiene composition containing monoalkyl and dialkyl ethers of dianhydrohexitols in the form of toothpate, mouthwash, chewing gums, confections, toothpicks and dental floss are effective in the cleaning of oral surfaces and cavities to reduce plaque accumulation caused by the action of bacteria.

  含有二氢己糖醇单烷基和二烷基醚的牙膏、漱口水、口香糖、糖果、牙签和牙线形式的口腔卫生组合物能有效清洁口腔表面和龋齿，减少细菌作用造成的牙菌斑堆积。
• HAIR COLORING COMPOSITIONS AND METHODS THEREOF
  申请人：Kao USA, Inc.

  公开号：EP3520769A1

  公开（公告）日：2019-08-07

  A hair coloring composition that includes about 5 to 25 wt.% of a first monosaccharide having 2 to 4 carbon atoms, up to about 10 wt.% of a second monosaccharide having 2 to 4 carbon atoms, about 0.1 to 5 wt.% of a surfactant, and about 0.1 to 5 wt.% of a delivery agent, each based on a total weight of the hair coloring composition. A method for coloring hair, that involves applying the hair coloring composition onto the hair, and optionally applying heat to the hair at a dyeing temperature of 30 to 205°C.

  一种染发组合物，包括约 5 至 25 重量％的具有 2 至 4 个碳原子的第一单糖、最多约 10 重量％的具有 2 至 4 个碳原子的第二单糖、约 0.1 至 5 重量％的表面活性剂和约 0.1 至 5 重量％的递送剂，每种物质均基于染发组合物的总重量。一种染发方法，包括将染发组合物涂抹在头发上，并可选择在 30 至 205°C 的染色温度下对头发进行加热。
• Controlled release delivery device comprising an organosol coat
  申请人：Intellipharmaceutics Corp.

  公开号：US10314787B2

  公开（公告）日：2019-06-11

  A controlled release delivery device for controlled release of an active ingredient comprising: (i) a core particle comprising the active ingredient homogenously dispersed or dissolved therein; and (ii) an organosol polymeric coat comprising a homogenous mixture of, (a) a water soluble gel forming polymer and a water insoluble organosoluble polymer in a dry weight ratio of from about 20:80 to about 50:50, (b) an organosolvent, and (c) an anti-tacking agent; the organosol polymeric coat being applied directly to and substantially enveloping the core particle.

  一种用于控制活性成分释放的控释给药装置，包括：(i)核心颗粒，其中包含均 匀分散或溶解的活性成分；和(ii)有机溶胶聚合物包衣，其中包含以下物质的均 匀混合物：(a)水溶性凝胶形成聚合物和水不溶性有机溶胶聚合物，干重比约为 20：80至约50:50，(b)有机溶剂，和(c)抗粘连剂；有机溶剂聚合涂层直接应用于核心颗粒并基本上包覆核心颗粒。