(2E,4E)-5-(3,4-dihydroxyphenyl)penta-2,4-dienoyl chloride | 1073666-66-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (2E,4E)-5-(3,4-dihydroxyphenyl)penta-2,4-dienoyl chloride
• CAS: 1073666-66-6
• 化学式: C₁₁H₉ClO₃
• 分子量: 224.644
• InChiKey: WDQPNXXTAYUTHV-ZPUQHVIOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.43
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.53
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (2E,4E)-5-(3,4-dihydroxyphenyl)penta-2,4-dienoyl chloride 、 姜黄素 在 吡啶 作用下， 反应 6.0h， 以45%的产率得到[4-[(1E,6E)-7-[4-[(2E,4E)-5-(3,4-dihydroxyphenyl)penta-2,4-dienoyl]oxy-3-methoxyphenyl]-3,5-dioxohepta-1,6-dienyl]-2-methoxyphenyl] (2E,4E)-5-(3,4-dihydroxyphenyl)penta-2,4-dienoate
  参考文献：
  名称：

  Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease

  摘要：

  Oxidative stress is implicated in mitochondrial dysfunction associated with neurodegeneration in Parkinson's disease (PD). Depletion of the cellular antioxidant glutathione (GSH) resulting in oxidative stress is considered as an early event in neurodegeneration. We previously showed that curcumin, a dietary polyphenol from turmeric induced GSH synthesis in experimental models and protected against oxidative stress. Here we tested the effect of three bioconjugates of curcumin ( involving diesters of demethylenated piperic acid, valine and glutamic acid) against GSH depletion mediated oxidative stress in dopaminergic neuronal cells and found that the glutamic acid derivative displayed improved neuroprotection compared to curcumin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.02.029

文献信息

• [EN] BENZENESULFONAMIDE DERIVATIVE
  申请人：EISAI CO., LTD.

  公开号：WO1991012237A1

  公开（公告）日：1991-08-22

  (EN) A novel benzenesulfonamide derivative of formula (I) which has an action of inhibiting phospholipase A2 and therefore is effective in treating diseases for which this action is used to advantage.(FR) Un nouveau dérivé de sulfonamide de benzène ayant la formule (I) a un effet inhibiteur de la phospholipase A2 et est par conséquent utile pour traiter des maladies lorsque cet effet inhibiteur est requis.

  一种新的苯磺酰胺衍生物，化学式为(I)，具有抑制磷脂酶A2的作用，因此在治疗需要利用这种作用的疾病中有效。