N-methyl-10,11-dihydro-5H-dibenzocyclohepten-5-imine | 59864-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 二苯并环庚烯
• 英文名称: N-methyl-10,11-dihydro-5H-dibenzocyclohepten-5-imine
• 英文别名: N-Methyl-10,11-dihydro-5H-dibenzocyclohepten-5-imin；N-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-imine；N-methyl-10,11-dihydro5H-dibenzo[a,d]cyclohepten-5-imine；N-methyltricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-imine
• CAS: 59864-51-6
• 化学式: C₁₆H₁₅N
• 分子量: 221.302
• InChiKey: CHJDOMSUALIXKA-UHFFFAOYSA-N

物化性质

• 沸点：
  332.1±42.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-methyl-10,11-dihydro-5H-dibenzocyclohepten-5-imine 、 N-甲基乙二胺 在 对甲苯磺酸 作用下， 反应 64.0h， 以68%的产率得到N-(2-methylamino-ethyl)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-imine
  参考文献：
  名称：

  Imine analogs of tricyclic antidepressants

  摘要：

  Analogues of tricyclic antidepressants were synthesized in which the alpha-carbon of the side chain was replaced by nitrogen. The antidepressant activity of these imines, as measured by the reversal of the effects of tetrabenazine in mice, showed a structure-activity relationship similar to that of the carbon analogues. The most active imine (19) was six times as potent as amitriptyline. Some of the compounds differed from amitriptyline in that they produced stimulation in mice.

  DOI：

  10.1021/jm00135a018
• 作为产物：
  描述：

  10,11-二氢二苯并[a,b]环庚烯-5-酮 、 甲胺 在 四氯化钛 作用下， 以 苯 为溶剂， 反应 288.0h， 以88%的产率得到N-methyl-10,11-dihydro-5H-dibenzocyclohepten-5-imine
  参考文献：
  名称：

  Imine analogs of tricyclic antidepressants

  摘要：

  Analogues of tricyclic antidepressants were synthesized in which the alpha-carbon of the side chain was replaced by nitrogen. The antidepressant activity of these imines, as measured by the reversal of the effects of tetrabenazine in mice, showed a structure-activity relationship similar to that of the carbon analogues. The most active imine (19) was six times as potent as amitriptyline. Some of the compounds differed from amitriptyline in that they produced stimulation in mice.

  DOI：

  10.1021/jm00135a018

文献信息

• N-cycloalkyl substituted-10,11-dihydro 5H-dibenzo[a,d]
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US03954865A1

  公开（公告）日：1976-05-04

  5H-dibenzo[a,d]cyclohepten-5-imines having a cyclic alkyl group, such as cyclopropyl or cyclobutyl, and their 10,11-dihydro derivatives, are useful as plasticizers for polymers and also for their effect on the central nervous systems of mammals.

  具有环状烷基，例如环丙基或环丁基的5H-二苯并[a，d]环庚烯-5-亚胺及其10,11-二氢衍生物，可用作聚合物的增塑剂，也可用于对哺乳动物中枢神经系统的影响。
• US3954865A
  申请人：——

  公开号：US3954865A

  公开（公告）日：1976-05-04
• Imine analogs of tricyclic antidepressants
  作者：Engelbert Ciganek、Roy T. Uyeda、Marvin Cohen、Dewey H. Smith

  DOI：10.1021/jm00135a018

  日期：1981.3

  Analogues of tricyclic antidepressants were synthesized in which the alpha-carbon of the side chain was replaced by nitrogen. The antidepressant activity of these imines, as measured by the reversal of the effects of tetrabenazine in mice, showed a structure-activity relationship similar to that of the carbon analogues. The most active imine (19) was six times as potent as amitriptyline. Some of the compounds differed from amitriptyline in that they produced stimulation in mice.