(+/-)-3-[6-(hydroxy)-2naphthyl]-8-methyl-8-azabicyclo[3.2.1]oct-2-ene

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (+/-)-3-[6-(hydroxy)-2naphthyl]-8-methyl-8-azabicyclo[3.2.1]oct-2-ene
• 英文别名: 3-[6-(hydroxy)-2-naphthyl]-8-methyl-8-azabicyclo[3.2.1]oct-2-ene；6-(8-Methyl-8-azabicyclo[3.2.1]oct-2-en-3-yl)naphthalen-2-ol
• 化学式: C₁₈H₁₉NO
• 分子量: 265.355
• InChiKey: SHIOOTUSJNGFSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  sodium hydroxide 、 (+/-)-3-[6-(hydroxy)-2naphthyl]-8-methyl-8-azabicyclo[3.2.1]oct-2-ene 在 乙酸酐 作用下， 以 二氯甲烷 为溶剂， 生成 (+/-)-3-[6-(Acetyloxy)-2-naphthyl]-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumaric acid salt
  参考文献：
  名称：

  8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives

  摘要：

  本发明涉及新颖的8-azabicyclo［3.2.1.］辛-2-烯和-辛烷衍生物，发现它们在尼古丁乙酰胆碱受体上是胆碱能配体。由于它们的药理特性，本发明的化合物可能有助于治疗与中枢神经系统（CNS）的胆碱能系统、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由化学物质终止引起的戒断症状等多种疾病或紊乱。

  公开号：

  US20020035122A1

文献信息

• 8-Azabicyclo[3.2.1]oct-2-ene and -octane derivatives technical field
  申请人：NEUROSEARCH A/S

  公开号：US20040116703A1

  公开（公告）日：2004-06-17

  The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及一种新型的8-氮杂双环[3.2.1]辛-2-烯和-辛烷衍生物，这些衍生物被发现是乙酰胆碱受体的胆碱能配体。由于它们的药理特性，本发明的化合物可能对与中枢神经系统（CNS）的胆碱能系统相关的疾病或障碍，平滑肌收缩相关的疾病或障碍，内分泌疾病或障碍，神经退行性疾病或障碍，炎症、疼痛以及因滥用化学物质而引起的戒断症状等多种疾病或障碍的治疗有用。
• 8-azabicyclo(3.2.1)oct-2-ene derivatives and their use as nAChR ligands
  申请人：NEUROSEARCH A/S

  公开号：EP1382605A2

  公开（公告）日：2004-01-21

  The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型 8-氮杂双环[3.2.1]辛-2-烯衍生物，发现它们是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理特性，本发明化合物可用于治疗各种疾病或紊乱，如与中枢神经系统（CNS）胆碱能系统有关的疾病或紊乱、与平滑肌收缩有关的疾病或紊乱、内分泌疾病或紊乱、与神经变性有关的疾病或紊乱、与炎症有关的疾病或紊乱、疼痛以及终止滥用化学物质引起的戒断症状。
• 8-AZABICYCLO 3.2.1]OCT-2-ENE AND -OCTANE DERIVATIVES
  申请人：NEUROSEARCH A/S

  公开号：EP1133494B1

  公开（公告）日：2004-02-18
• US6680328B2
  申请人：——

  公开号：US6680328B2

  公开（公告）日：2004-01-20
• US7045522B2
  申请人：——

  公开号：US7045522B2

  公开（公告）日：2006-05-16