2,2'-(dibenzo[b,d]furan-2,8-diyl)bis(1H-indole-3-carbaldehyde) | 1402073-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2,2'-(dibenzo[b,d]furan-2,8-diyl)bis(1H-indole-3-carbaldehyde)
• 英文别名: 2-[8-(3-formyl-1H-indol-2-yl)dibenzofuran-2-yl]-1H-indole-3-carbaldehyde
• CAS: 1402073-82-8
• 化学式: C₃₀H₁₈N₂O₃
• 分子量: 454.485
• InChiKey: QCRJKZYIYLORPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2'-(dibenzo[b,d]furan-2,8-diyl)bis(1H-indole-3-carbaldehyde) 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以78%的产率得到(2,2'-(dibenzo[b,d]furan-2,8-diyl)bis(1H-indole-3,2-diyl))dimethanol
  参考文献：
  名称：

  Some electrophilic reactivity studies of di-(2-indolyl)dibenzofurans and di-(2-indolyl)carbazoles

  摘要：

  3,6-Bis-(2-indolyl)dibenzofurans 1,2, and carbazoles 3-6 underwent a range of electrophilic substitution reactions to produce formyl indoles 7-12, biindolyls 24-28 and 33-34, glyoxylamides 40-42, and amides 48. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.11.014
• 作为产物：
  描述：

  二苯并呋喃 在 aluminum (III) chloride 、 甲烷磺酸 、 溶剂黄146 、 三氯氧磷 作用下， 以 二硫化碳 、 乙醇 为溶剂， 反应 9.33h， 生成 2,2'-(dibenzo[b,d]furan-2,8-diyl)bis(1H-indole-3-carbaldehyde)
  参考文献：
  名称：

  Synthesis of macrocyclic systems derived from di-(2-indolyl)heteroarenes

  摘要：

  A number of new 3,6-di-(2-indolyl)-dibenzofuran and carbazole derivatives have been prepared from dibenzofuran and carbazole linkers via the Fischer indole synthesis. The bis-indoles were successfully formylated at C3 and the resulting dicarbaldehydes were combined with diamines to generate indole based imine macrocyclic systems. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.063

文献信息

• Synthesis of macrocyclic systems derived from di-(2-indolyl)heteroarenes
  作者：Ibrahim F. Sengul、Kasey Wood、Naresh Kumar、David StC. Black

  DOI：10.1016/j.tet.2012.08.063

  日期：2012.11

  A number of new 3,6-di-(2-indolyl)-dibenzofuran and carbazole derivatives have been prepared from dibenzofuran and carbazole linkers via the Fischer indole synthesis. The bis-indoles were successfully formylated at C3 and the resulting dicarbaldehydes were combined with diamines to generate indole based imine macrocyclic systems. (C) 2012 Elsevier Ltd. All rights reserved.
• Some electrophilic reactivity studies of di-(2-indolyl)dibenzofurans and di-(2-indolyl)carbazoles
  作者：Ibrahim F. Sengul、Kittiya Somphol、Hakan Kandemir、Naresh Kumar、David StC. Black

  DOI：10.1016/j.tet.2014.11.014

  日期：2014.12

  3,6-Bis-(2-indolyl)dibenzofurans 1,2, and carbazoles 3-6 underwent a range of electrophilic substitution reactions to produce formyl indoles 7-12, biindolyls 24-28 and 33-34, glyoxylamides 40-42, and amides 48. (C) 2014 Elsevier Ltd. All rights reserved.