meso-1,1,1,4,4,4-Hexafluor-2,3-diphenylbutandiol(2,3) | 1547-69-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: meso-1,1,1,4,4,4-Hexafluor-2,3-diphenylbutandiol(2,3)
• 英文别名: 1,1,1,4,4,4-Hexafluor-2,3-diphenyl-butandiol-2,3；1,1,1,4,4,4-Hexafluor-2,3-diphenylbutan-2,3-diol；Hexafluorpinakol；1,1,1,4,4,4-Hexafluoro-2,3-diphenylbutane-2,3-diol
• CAS: 1547-69-9
• 化学式: C₁₆H₁₂F₆O₂
• 分子量: 350.26
• InChiKey: AJBYSHYIHCXTJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 meso-1,1,1,4,4,4-Hexafluor-2,3-diphenylbutandiol(2,3) 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Lund, Torben; Lundgren, Birger; Lund, Henning, Acta Chemica Scandinavica, 1995, vol. 49, # 10, p. 755 - 761

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2,2-三氟苯乙酮 在 盐酸 作用下， 以 异丙醇 为溶剂， 生成 meso-1,1,1,4,4,4-Hexafluor-2,3-diphenylbutandiol(2,3)
  参考文献：
  名称：

  Fluorinated Alkoxides. Part IX. The Resolution Of Perfluoro(2,3-diphenylbutane-2,3-diol) and its use in preparing Optically Active Complexes Of Ni²⁺ and Cu²⁺

  摘要：

  全氟(2,3-二苯基丁烷-2,3-二醇)，CF₃(C₆F₅)C(OH)C(OH)(C₆F₅)CF₃，通过C₆F₅COCF₃的还原二聚化制备，已分离为中间型和DL型异构体，并通过其奎宁盐分离为光学对映体。双离子二醇PDBD²⁻作为二阴配位配体，可以分离出中性络合物(PDBD)-ML₂，其中L是中性含氮或含磷配体，M = Ni²⁺或Cu²⁺。使用分离的二醇可以制备光学活性金属配合物，并从其o.r.d./c.d.光谱中确定二醇的绝对构型。部分氟化二醇CF₃(C₆H₅)C(OH)C(OH)(C₆H₅)CF₃和CH₃(C₆F₅)C(OH)C(OH)(C₆F₅)CH₃也已从适当的酮类制备。前者似乎仅为中间型异构体，其螯合能力比完全氟化的类似物有限，而后者则没有配体性质；这些差异归因于低氟化程度导致的酸度降低。核磁共振研究表明，在全氟(2,3-二苯基丁烷-2,3-二醇)中，C₆F₅基团受到CF₃基团的空间位阻影响而受到阻碍旋转；从羟基质子到芳香氟原子的氢键作用的替代解释被认为不太可能。

  DOI：

  10.1139/v75-114

文献信息

• Extent of charge transfer in the photoreduction of phenyl ketones by alkylbenzenes
  作者：Peter J. Wagner、Royal J. Truman、Alan E. Puchalski、Ronald. Wake

  DOI：10.1021/ja00284a041

  日期：1986.11

  Rate constants for triplet-state reaction of various ring-substituted benzophenones (BPs), acetophenones (APs), and ..cap alpha..,..cap alpha..,..cap alpha..-trifluoroacetophenones (TFAs) with toluene and p-xylene have been determined by a combination of flash kinetics, steady-state quenching, and quantum yield measurements. The relative amounts of primary and tertiary radicals formed by reaction of

  各种环取代二苯甲酮 (BPs)、苯乙酮 (APs) 和 ..cap alpha..,..cap alpha..,..cap alpha..-三氟苯乙酮 (TFA) 与甲苯的三重态反应的速率常数和对二甲苯是通过闪光动力学、稳态猝灭和量子产率测量的组合来确定的。还测量了由相同酮与对伞花烃反应形成的伯基和叔基的相对量。对于所有三种类型的酮，速率常数与三线态酮还原电位密切相关。用甲苯-d/sub 8/ 和对二甲苯-d/sub 10/ 观察到的动力学同位素效应的大小随着酮变得更容易还原而减小。所有酮三联体主要通过电荷转移机制与烷基苯反应，随着酮变得更难还原，速率决定步骤从络合变为氢转移。反应性最低的 AP 三联体也可能通过简单的氢原子提取产生显着的反应。那些具有 n,..pi..* 最低三联体的酮（所有 BPs 和一些 APs）与对伞花烃反应，得到与叔丁氧基显示的 0.40 值相差不超过 2 倍的伯/叔自由基比率自由基；那些具有
• Cobalt-electrocatalytic C–H hydroxyalkylation of <i>N</i>-heteroarenes with trifluoromethyl ketones
  作者：Tianyu He、Chaoqiang Liang、Shenlin Huang

  DOI：10.1039/d2sc05198b

  日期：——

  by radical addition to heteroarenes and rearomatization to afford tertiary alcohol products. Importantly, the merging of paired electrolysis and cobalt catalysis is crucial to this regioselective C–H hydroxyalkylation of heteroarenes, and thus avoids several known competing pathways including the spin-center shift (SCS) process. Collectively, this protocol provides straightforward access to heteroaryl

  三氟甲基甲醇和N -杂芳烃在生物活性分子中都很普遍。然而，获得结合这两个功能组的高价值药效团仍然是一个挑战。在此，我们报告了一种电化学氧化还原-中性偶联，用于从容易获得的N合成N -杂芳基三氟甲基甲醇- 杂芳烃和三氟甲基酮。该反应首先通过电催化质子偶联电子转移 (PCET) 将酮的极性逆转为亲核羰基自由基，然后对杂芳烃进行自由基加成并重芳构化，得到叔醇产物。重要的是，配对电解和钴催化的结合对于杂芳烃的这种区域选择性 C-H 羟烷基化至关重要，从而避免了几种已知的竞争途径，包括自旋中心偏移 (SCS) 过程。总的来说，该协议提供了对杂芳基三氟甲基甲醇的直接访问，具有理想的原子经济性、出色的区域选择性和成对的氧化还原中性电解。
• Reactive plastisol dispersion
  申请人：W.R. Grace & Co.-Conn.

  公开号：EP0124808A1

  公开（公告）日：1984-11-14

  This invention reiates to a reactive plastisol dispersion composition comprising (1) at least one polyvinyl acetal thermoplast in powder form, which is insoluble in the plasticizer at room temperature and plasticizable at a temperature at or above fluxing temperature, and which thermoplast has a flow temperature at 1,000 psi of between 100° and 200°C; (2) a liquid plasticizer comprising an epoxide resin having on average more than one epoxide group in the molecule or a mixture of said epoxide resins in combination with a member of the group consisting of (a) at least one ethylenically unsaturated monomer, oligomer or prepolymer of the formula: wherein R is H or CH3, R, is an organic moiety and n is 1 or more, (b) at least one unsaturated polyester containing the group: wherein R2 and R3 are organic moieties, x is 0-20 and y is 1-20 and y is 1-20, and (c) a mixture of (a) and (b); (3) an effective amount of a latent curing agent for said epoxide resin, which is inactive in the epoxide resin at room temperature and which is selected from the group consisting of dicyandiamide, melamine,guanamine, polycarboxylic acid polyhydrazides, carboxylic acid imides, imidazole derivatives, BF3 adducts and diaryliodonium salts; and, optionally, (4) a curing agent for the plasticizer group member comprising a free radical thermal initiator. The plastisol dispersion after fluxing can form a thermoset sealant, coating or adhesive on exposure to heat.

  本发明涉及一种反应性塑溶胶分散体组合物，其中包括 (1) 至少一种粉末状的聚乙烯醇缩醛热塑性塑料，它在室温下不溶于增塑剂，在助熔温度或更高的温度下可增塑，该热塑性塑料在 1,000 psi 下的流动温度在 100° 至 200°C 之间； (2) 液体增塑剂，包括分子中平均含有一个以上环氧基团的环氧树脂或上述环氧 树脂的混合物，并与以下组成成分结合使用 (a) 至少一种乙烯基不饱和单体、低聚物或预聚物，其式如下 其中 R 为 H 或 CH3，R 为有机分子，n 为 1 或更多、 (b) 至少一种含有以下基团的不饱和聚酯： 其中 R2 和 R3 为有机分子，x 为 0-20，y 为 1-20，以及 (c) (a)和(b)的混合物； (3) 有效量的用于所述环氧树脂的潜伏固化剂，该固化剂在室温下在环氧树脂中不活跃，且选 自二氰胺、三聚氰胺、胍胺、聚羧酸多酰肼、羧酸酰亚胺、咪唑衍生物、BF3 加合物和二元碘鎓盐组成的组； 以及 (4) 用于增塑剂基团成员的固化剂，包括自由基热引发剂。 经过助熔处理的塑溶胶分散体受热后可形成热固性密封剂、涂层或粘合剂。
• One component thermoset composition
  申请人：W.R. GRACE & CO.

  公开号：EP0130389A2

  公开（公告）日：1985-01-09

  @ This invention relates to a one component thermosettable reactive plastisol composition comprising (1) at least one thermoplast in powder form containing at least two active hydrogen groups, e.g., polyvinyl acetals, polyvinyl alcohol, acrylic or methacrylic acid copolymers, acrylamides, hydroxyethyl acrylate or methacrylate copolymer; (2) a liquid plasticizer having isocyanate or blocked isocyanate terminal groups, either per se or in combination with a plasticizer group member selected from the group consisting of (a) an acrylate terminated monomer, oligomer or propolymer, (b) an epoxide resin containing more than one epoxide group per molecule, and (c) a mixture of (a) and (b). The composition can optionally also contain a conventional accelerator for the reaction between isocyanate and active hydrogen groups as well as latent curing agents for the epoxide resin and free radical thermal initiators for the acrylate terminated monomer, oligomer or prepolymer. The composition is useful as an adhesive, sealant or coating and when heated at or above its fluxing temperature acquires good handling strength due to plasticization and good structural strength after heat curing. Further curing on aging is obtained through the reaction of moisture with any isocyanate residue.

  @ 本发明涉及一种单组分热固性反应型塑溶胶组合物，其中包括 (1) 至少一种含有至少两个活性氢基的粉末状热塑性塑料，例如聚乙烯醇、聚乙烯醇、丙烯酸或甲基丙烯酸共聚物、丙烯酰胺、丙烯酸羟乙酯或甲基丙烯酸酯共聚物； (2) 具有异氰酸酯或嵌段异氰酸酯末端基团的液体增塑剂，其本身或与增塑剂基 团成员结合使用均可，增塑剂基团成员选自以下组别 (a) 以丙烯酸酯为末端的单体、低聚物或预聚物、 (b) 分子中含有一个以上环氧基团的环氧树脂，以及 (c) (a) 和 (b) 的混合物。 该组合物还可选择含有异氰酸酯与活性氢基反应的常规促进剂，以及环氧化物树脂的潜在固化剂和丙烯酸酯端单体、低聚物或预聚物的自由基热引发剂。 该组合物可用作粘合剂、密封剂或涂料，在助熔温度或更高的温度下加热时，由于塑化作用可获得良好的操作强度，热固化后可获得良好的结构强度。通过水分与异氰酸酯残留物的反应，可在老化过程中进一步固化。
• Reactive plastisol
  申请人：W.R. GRACE & CO.

  公开号：EP0209658A2

  公开（公告）日：1987-01-28

  This invention relates to a thermosetting plastisol dispersion composition comprising (1) poly(phenylene oxide) (PPO) in powder form, which is insoluble in the reactive plasticizer at room temperature and plasticizable at a temperature at or above the fluxing temperature; (2) a liquid reactive plasticizer member of the group consisting of (a) at least one epoxide resin having an average of more than one epoxide group in the molecule, (b) at least one liquid monomer, oligomer or prepolymer containing at least one ethylenically unsaturated group and (c) a mixture of - (a) and (b); said liquid reactive plasticizer being capable of solvating the PPO at the fluxing temperature and being present in an amount ranging from 5 to 2,000 parts per 100 parts by weight of (1); and (3) 0.01 to 10% by weight of (2) of either a thermal initiator or photoinitiator for plasticizers present in the composition. The plastisol dispersion after fluxing can form a thermoset after the crosslinking reaction.

  本发明涉及一种热固性塑料溶胶分散体组合物，其中包括 (1) 粉末状聚环氧苯(PPO)，常温下不溶于活性增塑剂，在助熔温度或更高的温度下可增塑； (2) 一种液态活性增塑剂，属于以下组别：(a) 分子中平均含有一个以上环氧基团的 至少一种环氧树脂，(b) 含有至少一个乙烯不饱和基团的至少一种液态单体、 低聚物或预聚物，(c) (a)和(b)的混合物；所述液态活性增塑剂能在助熔温度下溶解 PPO，其含量为每 100 份（重量）(1) 含 5 至 2,000 份；以及 (3) 以重量计，(2)中的热引发剂或光引发剂占组合物中增塑剂的 0.01 至 10%。 经助焊剂处理后的塑料溶胶分散体可在交联反应后形成热固性塑料。