12-(2,2-Diethoxy-ethoxy)-2,3,8,9-tetramethoxy-benzo[c]phenanthridine | 852527-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 12-(2,2-Diethoxy-ethoxy)-2,3,8,9-tetramethoxy-benzo[c]phenanthridine
• CAS: 852527-91-4
• 化学式: C₂₇H₃₁NO₇
• 分子量: 481.546
• InChiKey: QUOWXTHDJCKYQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.35
• 重原子数：
  35.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  77.5
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  12-(2,2-Diethoxy-ethoxy)-2,3,8,9-tetramethoxy-benzo[c]phenanthridine 在 PPA 作用下， 生成
  参考文献：
  名称：

  Antimalarial benzo[c]phenanthridines

  摘要：

  Analogues of the antimalarial alkaloid nitidine have been prepared with high potency against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. Simple modifications, using an established synthetic route, resulted in an analogue with IC50 below 5 ng/mL against a chloroquine-sensitive strain of P. falciparum. N-Ethylethoxidine had IC50 below 30 ng/ mL against both chloroquine-sensitive and chloroquine-resistant strains of P. falciparum. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.074
• 作为产物：
  描述：

  2,3,8,9-Tetramethoxybenzophenanthridin-12-ol 、 2-溴-1,1-二乙氧基乙烷 生成 12-(2,2-Diethoxy-ethoxy)-2,3,8,9-tetramethoxy-benzo[c]phenanthridine
  参考文献：
  名称：

  Antimalarial benzo[c]phenanthridines

  摘要：

  Analogues of the antimalarial alkaloid nitidine have been prepared with high potency against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. Simple modifications, using an established synthetic route, resulted in an analogue with IC50 below 5 ng/mL against a chloroquine-sensitive strain of P. falciparum. N-Ethylethoxidine had IC50 below 30 ng/ mL against both chloroquine-sensitive and chloroquine-resistant strains of P. falciparum. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.074