5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯 | 521-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 二苯并环庚烯
• 中文名称: 5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯
• 英文名称: N,N-dimethyl-3-(5H-dibenzo[a,d]cyclohepten-5-yl)-propylamine
• 英文别名: N-Methylprotriptyline；5-(3-N,N-dimethylaminopropyl)-5H-dibenzocycloheptene；protriptyline；protriptylin；5-(3-dimethylaminopropyl)-5H-dibenzo[a,d]cycloheptene；N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-5-propylamine；N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine
• CAS: 521-80-2
• 化学式: C₂₀H₂₃N
• 分子量: 277.409
• InChiKey: YVBGGZGCBWNVDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯 在 氯甲酸乙烯酯 作用下， 生成 普罗替林
  参考文献：
  名称：

  Reactions of Sodiurn Borohydride in Acidic Media; IV. Reduction of Diarylmethanols and Triarylmethanols in Trifluoroacetic Acid^1-3

  摘要：

  DOI：

  10.1055/s-1977-24308
• 作为产物：
  描述：

  5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯-5-醇 在 sodium tetrahydroborate 、 三氟乙酸 作用下， 生成 5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯
  参考文献：
  名称：

  Reactions of Sodiurn Borohydride in Acidic Media; IV. Reduction of Diarylmethanols and Triarylmethanols in Trifluoroacetic Acid^1-3

  摘要：

  DOI：

  10.1055/s-1977-24308

文献信息

• Process for dibenzocycloheptene compounds
  申请人：Merck & Co., Inc.

  公开号：US04235820A1

  公开（公告）日：1980-11-25

  This invention relates to a process for the preparation of 5H-dibenzo[a,d]cycloheptene compounds and derivatives having aminoalkyl substituents at the 5-position by reducing the corresponding 5-aminoalkyl-5-hydroxy compounds with an alkali metal borohydride in trifluoroacetic acid.

  本发明涉及一种制备在5位具有氨基烷基取代基的5H-二苯并[a,d]环庚烯化合物和衍生物的方法，通过在三氟乙酸中用碱金属硼氢化物还原相应的5-氨基烷基-5-羟基化合物来实现。
• Antidepressants. Tetrabenazine-antagonizing activity in a series of 5H-dibenzo[cycloheptene-5-propylamines
  作者：Edward L. Engelhardt、Marcia E. Christy、C. Dylion Colton、Mark B. Freedman、Carole C. Boland、Lawrence M. Halpern、Vernon G. Vernier、Clement Addison Stone

  DOI：10.1021/jm00308a031

  日期：1968.3
• TRICYCLIC COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF
  申请人：ORLOW Seth J.

  公开号：US20090304615A1

  公开（公告）日：2009-12-10

  A method of identification of tricyclic compounds (formula I) that control melanin synthesis (melanogenesis), and the use of such compounds and compositions thereof to modify (e.g., inhibit) melanin production are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including by way of non-limiting example, hyperpigmentation and others.
• TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS
  申请人：Arbiser Jack L.

  公开号：US20100189762A1

  公开（公告）日：2010-07-29

  Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.
• US3978121A
  申请人：——

  公开号：US3978121A

  公开（公告）日：1976-08-31