garcinone B | 76996-28-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: garcinone B
• 英文别名: 5,9,11-trihydroxy-3,3-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-a]xanthen-12-one
• CAS: 76996-28-6
• 化学式: C₂₃H₂₂O₆
• 分子量: 394.424
• InChiKey: HVXHJNVYRXRHNX-UHFFFAOYSA-N

物化性质

• 沸点：
  645.7±55.0 °C(Predicted)
• 密度：
  1.340±0.06 g/cm3(Predicted)
• 物理描述：
  Solid
• 熔点：
  190-192°C

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

制备方法与用途

Garcinone B 是一种源自山竹果皮的氧杂蒽酮衍生物，它是一种有效的ACE2和Mpro抑制剂，并可用于COVID-19的研究。

反应信息

• 作为反应物：
  描述：

  garcinone B 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 苯 为溶剂， 反应 3.0h， 以30 mg的产率得到brasilixanthone B
  参考文献：
  名称：

  The structures of garcinones a, b and c: Three new xanthones from Garcinia mangostana

  摘要：

  DOI：

  10.1016/s0031-9422(82)85052-8
• 作为产物：
  描述：

  gamma-倒捻子素 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 苯 为溶剂， 反应 0.75h， 以60 mg的产率得到garcinone B
  参考文献：
  名称：

  The structures of garcinones a, b and c: Three new xanthones from Garcinia mangostana

  摘要：

  DOI：

  10.1016/s0031-9422(82)85052-8

文献信息

• Xanthone-rich plant extracts or compounds therefrom for modulating diseases of the central nervous system and related disorders
  申请人：Deakin University

  公开号：US10568862B2

  公开（公告）日：2020-02-25

  The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal in need thereof an effective amount of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract. The invention also relates to use of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, in the preparation of a medicament for the treatment and/or prophylaxis of a disease or disorder of the central nervous system and to a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, for use in the treatment and/or prophylaxis of a disease or disorder of the central nervous system.

  本发明涉及一种治疗和/或预防中枢神经系统疾病或紊乱的方法，包括向需要的哺乳动物施用有效量的富含黄酮的植物提取物或从富含黄酮的植物提取物衍生的化合物。 本发明还涉及富含黄酮的植物提取物或由富含黄酮的植物提取物衍生的化合物在制备治疗和/或预防中枢神经系统疾病或紊乱的药物中的用途，以及富含黄酮的植物提取物或由富含黄酮的植物提取物衍生的化合物在治疗和/或预防中枢神经系统疾病或紊乱中的用途。
• XANTHONE-RICH PLANT EXTRACTS OR COMPOUNDS THEREFROM FOR MODULATING DISEASES OF THE CENTRAL NERVOUS SYSTEM AND RELATED DISORDERS
  申请人：DEAKIN UNIVERSITY

  公开号：EP3110414B1

  公开（公告）日：2020-09-30
• [EN] XANTHONE-RICH PLANT EXTRACTS OR COMPOUNDS THEREFROM FOR MODULATING DISEASES OF THE CENTRAL NERVOUS SYSTEM AND RELATED DISORDERS<br/>[FR] EXTRAITS DE PLANTE RICHES EN XANTHONE OU COMPOSÉS DÉRIVÉS DE CEUX-CI POUR LA MODULATION DE MALADIES DU SYSTÈME NERVEUX CENTRAL ET DE TROUBLES ASSOCIÉS
  申请人：UNIV DEAKIN

  公开号：WO2015127512A1

  公开（公告）日：2015-09-03

  The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal in need thereof an effective amount of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract. The invention also relates to use of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, in the preparation of a medicament for the treatment and/or prophylaxis of a disease or disorder of the central nervous system and to a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, for use in the treatment and/or prophylaxis of a disease or disorder of the central nervous system.
• Sen, A. K.; Sarkar, K. K.; Majumder, P. C., Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980, vol. 19, # 11, p. 1008
  作者：Sen, A. K.、Sarkar, K. K.、Majumder, P. C.、Banerji, N.

  DOI：——

  日期：——
• The structures of garcinones a, b and c: Three new xanthones from Garcinia mangostana
  作者：Ashis K. Sen、Kalyan K. Sarkar、Pronobesh C. Mazumder、Nilima Banerji、Raimo Uusvuori、Tapio A. Hase

  DOI：10.1016/s0031-9422(82)85052-8

  日期：1982.1