3-(2-吡啶基)苯胺 | 39930-11-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-(2-吡啶基)苯胺
• 中文别名: 苯基(吡啶-2-基)甲胺
• 英文名称: 1-phenyl-1-(pyridin-2-yl)methanamine
• 英文别名: phenyl(pyridin-2-yl)methanamine；α-phenyl-2-pyridinemethylamine；phenyl-(pyridin-2-yl)-methylamine
• CAS: 39930-11-5
• 化学式: C₁₂H₁₂N₂
• mdl: MFCD00514135
• 分子量: 184.241
• InChiKey: BAEZXIOBOOEPOS-UHFFFAOYSA-N

物化性质

• 熔点：
  54-55 °C
• 沸点：
  159-165 °C(Press: 3 Torr)
• 密度：
  1.106±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 包装等级：
  III
• 危险类别：
  8
• 危险性防范说明：
  P260,P264,P280,P301+P310+P330+P331,P303+P361+P353+P310,P304+P340+P310,P305+P351+P338+P310,P363,P405,P501
• 危险品运输编号：
  2735
• 危险性描述：
  H314
• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  3-(2-吡啶基)苯胺 在 氧气 、 三乙胺 、 copper dichloride 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 4.0h， 生成 3-(1-methyl-1H-imidazol-2-yl)-1-phenyl-1-(pyridin-2-yl)-1H-benzo[f]isoindole-4,9-diol
  参考文献：
  名称：

  Copper-Mediated Oxidative Cyclization of Heterocyclically Substituted Aldimines

  摘要：

  Copper-mediated cascade reactions were performed with heterocyclically substituted aldimines. These oxidative heterocyclizations include sequences of oxidations and cycloadditions or nucleophilic additions which take place in the coordination sphere of copper ions. When two heterocyclically substituted aldimines were reacted in the presence of copper (II) salts under air, pyridine derivatives were produced. In one case a 1,4-diazatricyclo-[3.2.1.0(2,7)]oct-3-ene was also formed. The basic structure of this new tetracyclic compound contains five new chirale carbon atoms. This cage-like structure has been revealed by X-ray crystallography. The synthesis of 2H-pyrroles by copper-assisted conversions of the aldimines with dimethylacetylene carboxylate or quinones was also described.

  DOI：

  10.3987/com-10-11966
• 作为产物：
  描述：

  2-氰基吡啶 生成 3-(2-吡啶基)苯胺
  参考文献：
  名称：

  Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds

  摘要：

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。

  公开号：

  US06506782B1

文献信息

• New substituted imidazo[1,5-a]pyridine and imidazo[5,1-a]isoquinoline derivatives and their application in fluorescence cell imaging
  作者：G. Volpi、B. Lace、C. Garino、E. Priola、E. Artuso、P. Cerreia Vioglio、C. Barolo、A. Fin、A. Genre、C. Prandi

  DOI：10.1016/j.dyepig.2018.04.037

  日期：2018.10

  A series of new dyes based on the fluorescent imidazo[1,5-a]pyridine moiety has been designed and synthesized specifically for fluorescence cell imaging application. The obtained molecules contain a carboxylic functional group inserted to increase the water solubility and to provide an effective conjugation site. Their structural and optical properties have been deeply investigated and compared with

  已经设计并合成了一系列基于荧光咪唑并[1,5- a ]吡啶部分的新型染料，专门用于荧光细胞成像应用。所获得的分子包含插入的羧基官能团以增加水溶性并提供有效的缀合位点。对它们的结构和光学性质进行了深入研究，并与理论计算进行了比较。已经通过激光扫描共聚焦显微镜在拟南芥幼苗体内和体外研究了该产品作为荧光标记物在细胞成像中的适用性。，在小鼠成纤维细胞上。该化合物对植物细胞壁和质膜具有良好的渗透性，可以有效地内化在植物内部组织中，并在水性介质中保持强荧光。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020045747A1

  公开（公告）日：2002-04-18

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性治疗阿尔茨海默病的方法。
• Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation and their use
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1193248A1

  公开（公告）日：2002-04-03

  The present invention relates to compounds of the of the formula I, in which R1, R2, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

  本发明涉及式I化合物的化合物，其中R1，R2，A和B具有权利要求中指出的含义。式I的化合物是有价值的药理活性化合物。它们展现出强大的抗血栓作用，并适用于例如治疗和预防血栓栓塞性疾病和再狭窄。它们是血液凝固酶因子VIIa的可逆抑制剂，通常可以应用于因子VIIa存在不需要活性或治疗或预防因子VIIa抑制的情况。本发明还涉及用于制备式I化合物的方法，其用途，尤其是作为药品中的活性成分，以及包含它们的药物制剂。
• Synthesis and gastric antisecretory activity of N-cyano-N'-(phenyl-pyridinylmethyl)guanidine derivatives.
  作者：KATSUTOSHI SHIMADA、HIDEAKI FUJISAKI、KIYOSHI OKETANI、MANABU MURAKAMI、TADAO SHOJI、TSUNEO WAKABAYASHI、KOICHIRO UEDA、KIICHI EMA、KAZUNORI HASHIMOTO、SATORU TANAKA

  DOI：10.1248/cpb.32.4893

  日期：——

  N-Alkyl-N'-cyano-N"-(substituted phenyl-pyridinylmethyl) guanidine derivatives were synthesized and tested for inhibitory activity against gastric secretion in rats. Several of the compounds synthesized showed an inhibiting activity as potent as that of cimetidine against basal gastric secretion but showed less potent activity than cimetidine against histamine-stimulated gastric secretion. Some structure-activity relationships are discussed.

  N-烷基-N'-氰基-N"-(取代苯基吡啶甲基)胍衍生物被合成并测试了对大鼠胃分泌的抑制活性。合成的化合物中，有几个展现了对基础胃分泌的抑制活性，与西咪替丁相当，但在对抗组胺刺激的胃分泌方面，活性不如西咪替丁。还讨论了一些结构-活性关系。
• [EN] SUBSTITUTED QUINOLINE COMPOUNDS<br/>[FR] COMPOSES DE QUINOLINE SUBSTITUES
  申请人：PFIZER PROD INC

  公开号：WO2005080373A1

  公开（公告）日：2005-09-01

  This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.

  本发明涉及式(I)的MTP/Apo-B分泌抑制剂，其中R1-R7、X1、m和n的定义如说明书中所述，以及包含这些化合物的药物组合物，以及这些化合物和组合物的使用方法。本发明的化合物可用于治疗肥胖及其相关疾病、状况或失调。