(3-氯丙基)甲基二乙烯基硅烷 | 123229-38-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: (3-氯丙基)甲基二乙烯基硅烷
• 英文名称: (3-chloropropyl)methyldivinylsilane
• 英文别名: 3-Chloropropylmethyldivinylsilane；3-chloropropyl-bis(ethenyl)-methylsilane
• CAS: 123229-38-9
• 化学式: C₈H₁₅ClSi
• 分子量: 174.746
• InChiKey: ORCHSSOHUOWREO-UHFFFAOYSA-N

物化性质

• 沸点：
  186.1±32.0 °C(Predicted)
• 密度：
  0.882±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.14
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (3-氯丙基)甲基二乙烯基硅烷 在 吡啶 、 magnesium 、 1,2-二溴乙烷 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 2.08h， 生成 [Dimethyl-[2-[tris[2-[4-[bis(ethenyl)-methylsilyl]butanoyloxy-dimethylsilyl]ethyl]silyl]ethyl]silyl] 4-[bis(ethenyl)-methylsilyl]butanoate
  参考文献：
  名称：

  Design and synthesis of readily degradable acyloxysilane dendrimers

  摘要：

  Two types of dendrimers with AB(2) branching, one with acyloxysilanes at the branching position (V type) and the other at the non-branching position (Y type), were synthesized using hydrosilylation with chlorosilanes followed by heterofunctional condensation with olefin-functional carboxylic acids, and examined as readily degradable template materials. The V type dendrimer was much more susceptible to ligand redistribution with chlorosilanes during preparation, whereas the Y type was less. The acyloxysilane linkages in these dendrimers could be cleaved readily by alcoholysis or hydrolysis on demand, making for suitable templates. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.068
• 作为产物：
  描述：

  3-氯丙基甲基二氯硅烷 、 乙烯基溴化镁 以 四氢呋喃 为溶剂， 反应 1.0h， 以76%的产率得到(3-氯丙基)甲基二乙烯基硅烷
  参考文献：
  名称：

  Design and synthesis of readily degradable acyloxysilane dendrimers

  摘要：

  Two types of dendrimers with AB(2) branching, one with acyloxysilanes at the branching position (V type) and the other at the non-branching position (Y type), were synthesized using hydrosilylation with chlorosilanes followed by heterofunctional condensation with olefin-functional carboxylic acids, and examined as readily degradable template materials. The V type dendrimer was much more susceptible to ligand redistribution with chlorosilanes during preparation, whereas the Y type was less. The acyloxysilane linkages in these dendrimers could be cleaved readily by alcoholysis or hydrolysis on demand, making for suitable templates. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.068

文献信息

• Surface Modified Organic Inorganic Hybrid Glass, Protecting Group Induced Alcohol or Its Derivative and Producing Method Thereof
  申请人：Jun Chul-Ho

  公开号：US20090274910A1

  公开（公告）日：2009-11-05

  Disclosed are a protected alcohol or derivative thereof, a surface-modified organic-inorganic hybrid glass, and preparation methods thereof. More specifically, disclosed are a protected alcohol or derivative thereof and a surface-modified organic-inorganic hybrid glass, which are prepared by allowing a silane compound, having vinyl or a vinyl derivative, to react with an alcohol or derivative thereof or with an organic-inorganic hybrid glass, in the presence of an acid catalyst, a transition metal catalyst and an organic solvent, so as to introduce an organic group thereto even at room temperature, as well as preparation methods thereof. The disclosed invention allows a functional group to be effectively introduced into alcohol or a derivative thereof or into an organic-inorganic hybrid glass, not only high temperatures but also room temperature, and thus is highly effective in introducing compounds having a thermally sensitive functional group, for example, natural compounds or proteins. Also, the invention makes it possible to introduce various organic groups and to separate and purify organic macromolecule-bonded organosilane compounds using a silica gel column so as to effectively introduce large organic functional groups to inorganic materials. Accordingly, the invention is highly useful in the chemical industry.

  本文揭示了一种受保护的醇或其衍生物、一种表面改性的有机-无机混合玻璃及其制备方法。更具体地，本文揭示了一种受保护的醇或其衍生物以及一种表面改性的有机-无机混合玻璃，通过让具有乙烯或乙烯衍生物的硅烷化合物在酸催化剂、过渡金属催化剂和有机溶剂的存在下与醇或其衍生物或有机-无机混合玻璃发生反应，从而在室温下引入有机基团，以及其制备方法。本发明允许在醇或其衍生物或有机-无机混合玻璃中有效引入功能基团，不仅在高温下，而且在室温下，因此在引入具有热敏功能基团的化合物方面非常有效，例如天然化合物或蛋白质。此外，该发明使得可以引入各种有机基团，并且利用硅胶柱分离和纯化有机大分子结合的有机硅烷化合物，从而有效地将大有机功能基团引入无机材料中。因此，该发明在化学工业中具有非常高的实用性。
• Strategies for penicillin V dendronization with cationic carbosilane dendrons and study of antibacterial properties
  作者：Elena Fuentes-Paniagua、José M. Hernández-Ros、Juan Soliveri、José L. Copa-Patiño、Rafael Gómez、Javier Sánchez-Nieves、F. Javier de la Mata

  DOI：10.1139/cjc-2017-0059

  日期：2017.9

  Strategies to synthesize a cationic carbosilane dendron containing the antibiotic penicillin V potassium salt (PenVK) at the focal point are discussed. The preparation of such a compound requires the use of systems with no donor atoms such as N or S in their framework, because their presence favours the rupture of the penicillin β-lactam ring. The antibacterial activity of the new dendron containing ammonium groups, at the periphery, and the PenV moiety, at the focal point, against gram-positive Staphylococcus aureus strains was evaluated. These results were compared with those obtained for free PenVK, a related cationic dendron without a penicillin moiety at the focal point, and also compared with an equimolar mixture of this last dendron with free PenV. The data obtained indicate that, on one hand, the conjugation or interaction of PenV with cationic dendrons reduces its activity in comparison with free PenVK. On the other hand, the penicillin dendron is able to release the antibiotic in the presence of esterease, due to the breaking of the ester bond in this derivative.

  讨论了合成含有抗生素青霉素V钾盐（PenVK）的阳离子碳硅烷树枝的策略。制备这种化合物需要使用没有供体原子（如N或S）的系统，因为它们的存在有利于破坏青霉素β-内酰胺环。评估了新树枝含有铵基团在外围和PenV基团在焦点处对革兰氏阳性金黄色葡萄球菌菌株的抗菌活性。这些结果与自由PenVK、焦点处没有青霉素基团的相关阳离子树枝以及这种最后一个树枝与自由PenV的等摩尔混合物所获得的结果进行了比较。所获得的数据表明，一方面，PenV与阳离子树枝的共轭或相互作用使其活性降低，与自由PenVK相比。另一方面，青霉素树枝能够在酯酶存在的情况下释放抗生素，因为这种衍生物中酯键的断裂。
• ORGANIC SILICONE COMPOUND
  申请人：Koike Noriyuki

  公开号：US20100160588A1

  公开（公告）日：2010-06-24

  The purpose of the present invention is to provide an organic silicon compound which has a vinyl group more reactive than those of the conventional organic silicon compounds and can be bonded with another compound. The present organic silicon compound is represented by the following formula (1), wherein R 1 is, independently of each other, a vinyl group or an alkyl group having 1 to 4 carbon atoms, R 2 is an alkylene group having 3 to 6 carbon atoms, and R 3 is, independently of each other, a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and optionally substituted with one or more fluorine atoms.

  本发明的目的是提供一种有机硅化合物，其具有比传统有机硅化合物更具反应性的乙烯基，并且可以与另一种化合物结合。本有机硅化合物由以下式（1）表示，其中R1分别是乙烯基或具有1至4个碳原子的烷基基团，R2是具有3至6个碳原子的烷基基团，R3分别是氢原子或具有1至4个碳原子的烷基基团，并且可以选择地被一个或多个氟原子取代。
• Surface modified organic inorganic hybrid glass, protecting group induced alcohol or its derivative and producing method thereof
  申请人：Industry-Academic Cooperation Foundation Yonsei University

  公开号：US08197903B2

  公开（公告）日：2012-06-12

  Disclosed are a protected alcohol or derivative thereof, a surface-modified organic-inorganic hybrid glass, and preparation methods thereof. More specifically, disclosed are a protected alcohol or derivative thereof and a surface-modified organic-inorganic hybrid glass, which are prepared by allowing a silane compound, having vinyl or a vinyl derivative, to react with an alcohol or derivative thereof or with an organic-inorganic hybrid glass, in the presence of an acid catalyst, a transition metal catalyst and an organic solvent, so as to introduce an organic group thereto even at room temperature, as well as preparation methods thereof. The disclosed invention allows a functional group to be effectively introduced into alcohol or a derivative thereof or into an organic-inorganic hybrid glass, not only high temperatures but also room temperature, and thus is highly effective in introducing compounds having a thermally sensitive functional group, for example, natural compounds or proteins. Also, the invention makes it possible to introduce various organic groups and to separate and purify organic macromolecule-bonded organosilane compounds using a silica gel column so as to effectively introduce large organic functional groups to inorganic materials. Accordingly, the invention is highly useful in the chemical industry.

  本发明涉及一种保护的醇或其衍生物、表面改性的有机-无机杂化玻璃及其制备方法。具体而言，本发明涉及一种通过在酸催化剂、过渡金属催化剂和有机溶剂的存在下，让具有乙烯或乙烯衍生物的硅烷化合物与醇或其衍生物或有机-无机杂化玻璃反应，以便即使在室温下引入有机基团的保护醇或其衍生物或有机-无机杂化玻璃以及其制备方法。本发明不仅可以在高温下，而且可以在室温下有效地引入功能基团到醇或其衍生物或有机-无机杂化玻璃中，因此在引入具有热敏功能基团的化合物，例如天然化合物或蛋白质时具有高效性。此外，本发明使得引入各种有机基团成为可能，并且可以使用硅胶柱分离和纯化有机大分子键合的有机硅烷化合物，以便将大的有机功能基团有效地引入无机材料中。因此，本发明在化学工业中具有高度的实用性。
• Organic silicone compound
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US08143359B2

  公开（公告）日：2012-03-27

  The purpose of the present invention is to provide an organic silicon compound which has a vinyl group more reactive than those of the conventional organic silicon compounds and can be bonded with another compound. The present organic silicon compound is represented by the following formula (1), wherein R1 is, independently of each other, a vinyl group or an alkyl group having 1 to 4 carbon atoms, R2 is an alkylene group having 3 to 6 carbon atoms, and R3 is, independently of each other, a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and optionally substituted with one or more fluorine atoms.

  本发明的目的是提供一种有机硅化合物，其具有比传统有机硅化合物更具反应性的乙烯基，并且可以与另一化合物结合。该有机硅化合物由以下公式（1）表示，其中R1独立地表示乙烯基或具有1至4个碳原子的烷基，R2表示具有3至6个碳原子的烷基，而R3独立地表示氢原子或具有1至4个碳原子并可选择地取代一个或多个氟原子的烷基。