bis(8-hydroxyquinolinato)platinum(II) | 69176-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: bis(8-hydroxyquinolinato)platinum(II)
• 英文别名: platinum(II) bis-(8-hydroxyquinolinate)；[Ptq₂]；bis(8-quinolinolato-N,O)platinum(II)；bis(8-hydroxyquinolinato)platinum；platinum(II) complex with 8-quinolinol；trans-[platinum(II)(8-quinolinol-1H)2]；bis(8-hydroxyquinoinato)platinum(II)；bis(8-hydroxyquinolato)platinum(II)；[Pt(qol)2]；trans-Pt(II)(8-quinolinol-1H)2；trans-[Pt(qol)2]；Platinum(2+);quinolin-8-olate
• CAS: 69176-88-1
• 化学式: C₁₈H₁₂N₂O₂Pt
• 分子量: 483.385
• InChiKey: KBQCLXJHWJTXJJ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis(8-hydroxyquinolinato)platinum(II) 在 air 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Photochemical reactions in solutions of the platinum(II) complex with 8-quinolinol

  摘要：

  The rate of photochemical reaction in solutions of luminescent platinum(II) complex with 8-quinolinol was studied in relation to the type of solvent, irradiation time, photon energy and intensity of a luminous flux, concentration of the complex, and presence of oxygen. The structure of the photochemical reaction product was studied by X-ray photoelectron, IR, and electronic absorption spectroscopy. The quantitative kinetic parameters and quantum yield of the photochemical reaction performed under various irradiation conditions are reported.

  DOI：

  10.1134/s1070427207120145
• 作为产物：
  描述：

  8-羟基喹啉 、 bis(hexafluoroacetylacetonate)platinum(II) 以 甲苯 为溶剂， 反应 20.0h， 以67%的产率得到bis(8-hydroxyquinolinato)platinum(II)
  参考文献：
  名称：

  基于简单Pt（II）OˆN-络合物的高效红色有机发光二极管

  摘要：

  首次观察到作为发射层的掺杂剂组分掺入多层OLED结构中的双（8-羟基喹啉）铂（II）的红橙色电致发光（CIE色度坐标X = 0.5389，Y = 0.3842）。据估计，上述配合物的高化学纯度对于良好的电致发光性质至关重要。此外，已开发出新的可靠的合成途径至PtQ 2，并对其光物理性质进行了研究。

  DOI：

  10.1016/j.dyepig.2016.06.018

文献信息

• Bis(8-quinolinolato-<i>N</i>,<i>O</i>)platinum(II) and its synthetic intermediate, 8-hydroxyquinolinium dichloro(8-quinolinolato-<i>N</i>,<i>O</i>)platinate(II) tetrahydrate
  作者：Masako Kato、Yuki Ogawa、Mikiko Kozakai、Yukihiro Sugimoto

  DOI：10.1107/s0108270102000045

  日期：2002.3.15

  Bis(8-quinolinolato-N,O)platinum(II), [Pt(C(9)H(6)NO)(2)], (I), has a centrosymmetric planar structure with trans coordination. The molecules form an inclined pi stack, with an interplanar spacing of 3.400 (6) A. 8-Hydroxyquinolinium dichloro(8-quinolinolato-N,O)platinate(II) tetrahydrate, (C(9)H(8)NO)[PtCl(2)(C(9)H(6)NO)] x 4H(2)O, (II), is soluble in water and is regarded as the synthetic intermediate

  Bis（8-quinolinolato-N，O）platinum（II），[Pt（C（9）H（6）NO）（2）]，（I）具有中心对称的平面结构，具有反式配位。这些分子形成一个倾斜的pi堆栈，其平面间距为3.400（6）A。四水合八水合羟基喹啉二氯（8-喹啉基-N，O）铂盐（II）（（C（9）H（8）NO）[ PtCl（2）（C（9）H（6）NO）] x 4H（2）O（II）溶于水，被认为是不溶性中性化合物（I）的合成中间体。未配位的8-羟基喹啉阳离子和单喹啉酸酯络合物形成交替的pi堆栈。（II）中荧光和磷光的起源分别与8-羟基喹啉阳离子和单喹啉酸酯-Pt络合物有关。
• Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: Synthesis, characterization, cytotoxicity, cell cycle and apoptosis
  作者：Qi-Pin Qin、Zhen-Feng Chen、Jiao-Lan Qin、Xiao-Ju He、Yu-Lan Li、Yan-Cheng Liu、Ke-Bin Huang、Hong Liang

  DOI：10.1016/j.ejmech.2014.12.052

  日期：2015.3

  Although 1, 2 and pifithrin-α caused serious inhibition on p53, 1 and 2 significantly cause the loss of mitochondrial membrane potential and increase of the reactive oxygen species level, cytochrome c, apaf-1 and caspase-3/9 ratio in BEL-7404 cells. 1 and 2 may trigger the cell apoptosis through a mitochondrial dysfunction pathway whereas pifithrin-α does not. The interactions of 1 and 2 with DNA are most

  [Pt（Q）2 ]（1）和[Pt（MQ）2 ]（2）对BEL-7404，Hep-G2，NCI-H460，T-24，A549肿瘤细胞表现出增强的细胞毒性，但对正常HL的细胞毒性较低-7702细胞。1和2可能分别导致细胞周期停滞在G2和S期。特定的p53抑制剂pifithrin-α诱导细胞周期停滞在G1期。尽管1，2和pifithrin-α引起的对p53，严重抑制1和2显著原因线粒体膜电位和活性氧物质的水平，细胞色素增加的损失Ç，BEL-7404细胞中apaf-1和caspase-3 / 9的比例。1和2可能通过线粒体功能障碍途径触发细胞凋亡，而pifithrin-α则不会。1和2与DNA的相互作用极有可能是通过插层作用。
• Excited state processes of dinuclear Pt(<scp>ii</scp>) complexes bridged by 8-hydroxyquinoline
  作者：Sarah Kromer、Subhangi Roy、James E. Yarnell、Chelsea M. Taliaferro、Felix N. Castellano

  DOI：10.1039/d3dt00348e

  日期：——

  Dinuclear d8 Pt(II) complexes, where two mononuclear square planar Pt(II) units are bridged in an “A-frame” geometry, possess photophysical properties characterised by either metal-to-ligand-(MLCT) or metal–metal–ligand-to-ligand charge transfer (MMLCT) transitions determined by the distance between the two Pt(II) centres. When using 8-hydroxyquinoline (8HQH) as the bridging ligand to construct novel

  双核 d 8 Pt( II ) 配合物，其中两个单核方形平面 Pt( II ) 单元以“A 框架”几何结构桥接，具有以金属对配体 (MLCT) 或金属-金属-为特征的光物理特性配体到配体电荷转移 (MMLCT) 跃迁由两个 Pt( II ) 中心之间的距离决定。以8-羟基喹啉(8HQH)为桥联配体构建通式为[C^NPt(μ-8HQ)] 2的新型双核配合物，其中C^N为2-苯基吡啶( 1 )或7,8-苯并喹啉( 2 )，以配体为中心的三重态 ( 3 LC) 光物理学结果与单核模型发色团中的结果相呼应，[Pt(8HQ)2 ] ( 3 )。3.255 Å ( 1 ) 和 3.243 Å ( 2 )的加长 Pt-Pt 距离导致以 480 nm 为中心的最低能量吸收被 TD-DFT 指定为具有混合 LC/MLCT 特征，反映了 3 的可见吸收光谱。此外， 1和2表现出3 LC 光致发光，量子产率有限
• Umapathy, P.; Chandrasekhar, S.; Ghuge, K. D., Journal of the Indian Chemical Society, 1981, vol. 58, p. 220 - 224
  作者：Umapathy, P.、Chandrasekhar, S.、Ghuge, K. D.

  DOI：——

  日期：——
• Thin-film conducting polymers based on Ni(II), Pd(II), and Pt(II) complexes with 8-quinolinol
  作者：M. S. Masalovich、L. P. Ardasheva、G. A. Shagisultanova

  DOI：10.1134/s1070427207080332

  日期：2007.8

  New thin polymeric films were prepared electrochemically on the basis of Ni(II), Pd(II), and Pt(II) complexes with 8-quinolinol, and conditions of synthesis were optimized. Basic characteristics of the films such as the thickness, charge transfer rate in the polymeric matrix, and photovoltaic effect were determined.