N,O-Dibenzoyltyramine | 41859-53-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: N,O-Dibenzoyltyramine
• 英文别名: O,N-dibenzoyltyramine；1-(2-benzoylamino-ethyl)-4-benzoyloxy-benzene；1-(2-Benzoylamino-aethyl)-4-benzoyloxy-benzol；N-[β-(4-Benzoyloxy-phenyl)-aethyl]-benzamid；4-[2-(Benzoylamine)ethyl]phenylbenzoate；[4-(2-benzamidoethyl)phenyl] benzoate
• CAS: 41859-53-4
• 化学式: C₂₂H₁₉NO₃
• 分子量: 345.398
• InChiKey: USWFQUUWZNITBV-UHFFFAOYSA-N

物化性质

• 熔点：
  172-173 °C
• 沸点：
  580.3±43.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,O-Dibenzoyltyramine 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以85%的产率得到N-[2-(4-羟基苯基)乙基]苯甲酰胺
  参考文献：
  名称：

  Cascade Cyclization: Synthesis of (+)-Tuberine

  摘要：

  Asymmetric dihydroxylation of epoxide 12 led, via biomimetic epoxide opening, to tetrahydrofuran 13. Acetylation of 13 then gave the antibiotic terpene (+)-tuberine (14). In the course of this work, the absolute configuration of (+)-tuberine was corrected.

  DOI：

  10.1021/jo00091a038
• 作为产物：
  描述：

  对羟基苯乙腈 在 sodium hydroxide 、 乙醇 、 sodium 作用下， 生成 N,O-Dibenzoyltyramine
  参考文献：
  名称：

  Barger, Journal of the Chemical Society, 1909, vol. 95, p. 1127

  摘要：

  DOI：

文献信息

• Water-Soluble Acylating Agents: Preparation of 2-Acylthio-1-alkylpyridinium Salts and Acylation of Phenols, Acids, and/or Amines with These Salts in an Aqueous Phase
  作者：Tohru Sakakibara、Yukie Watabe、Masahide Yamada、Rokuro Sudoh

  DOI：10.1246/bcsj.61.247

  日期：1988.1

  Reaction of phenols, amines, and acids with 2-benzoylthio-1-methylpyridinium chloride prepared in situ from benzoyl chloride and 1-methyl-2(1H)-pyridinethione, afforded the corresponding benzoyl derivatives in good yields. In the reaction of p-nitrophenol, even a catalytic amount of 1-methyl-2(1H)-pyridinethione proved to be effective. Similar reactions of p-nitrophenol with isobutyryl chloride and acetyl

  苯甲酰氯和 1-甲基-2(1H)-吡啶硫酮原位制备的 2-苯甲酰硫基-1-甲基氯化吡啶鎓与苯酚、胺和酸反应，以良好的收率得到相应的苯甲酰衍生物。在对硝基苯酚的反应中，即使是催化量的 1-甲基-2(1H)-吡啶硫酮也被证明是有效的。在 1-甲基-2(1H)-吡啶硫酮存在下，对硝基苯酚与异丁酰氯和乙酰氯的类似反应分别以 63% 和 44% 的产率得到对硝基苯异丁酸酯和对硝基苯乙酸酯。2-苯甲酰硫基-、2-乙酰硫基-和2-异丁酰硫基-1-乙基吡啶鎓四氟硼酸盐通过用四氟硼酸三乙基氧鎓处理相应的2-酰基硫代吡啶鎓来制备。这些吡啶鎓盐还在水相中充当酰化剂。
• Preparation of N,N-difluoroamines
  申请人：Research Institute for Medicine & Chemistry Inc.

  公开号：US04234515A1

  公开（公告）日：1980-11-18

  N,N-difluoroamines are prepared by fluorination of compounds containing a >C.dbd.N-- bond using molecular fluorine or a hypofluorite in which the fluoroxy group is bonded to an inert electron attracting group, such hypofluorites including fluoroalkyl hypofluorites such as trifluoromethyl hypofluorite. The fluorination is advantageously conducted in the presence of an alkanol or other nucleophilic compound. Suitable starting materials include imino ethers and esters and aliphatic and aromatic Schiff's bases, use of the latter being particularly convenient.

  N,N-二氟胺是通过使用分子氟或含有氟氧基与惰性电子吸引基团结合的次氟酸盐对含有>C.dbd.N--键的化合物进行氟化制备的，这些次氟酸盐包括三氟甲基次氟酸盐等。氟化反应在存在烷醇或其他亲核化合物的情况下有利地进行。适合的起始物质包括亚胺醚和酯以及脂肪和芳香亚胺碱，后者的使用特别方便。
• Specific synthesis of N-fluoro-compounds using perfluorofluoroxy-reagents
  作者：Derek H. R. Barton、Robert H. Hesse、Maurice M. Pechet、Hee T. Toh

  DOI：10.1039/p19740000732

  日期：——

  NN-difluoroamines. An aromatic ring that is not deactivated towards electrophilic attack reacts in preference to an amide. Conversion of amides into the more reactive imino-ethers overcomes this problem. This is illustrated by the synthesis of the NN-difluoro-derivatives of amphetamine and tyramine. Evidence is presented for the mechanism of these reactions.

  仲磺酰胺与全氟氟氧基化合物反应以高收率得到N-氟衍生物。对于仲羧酰胺，最初形成的N-氟酰胺进一步与酰胺键的裂解反应，并形成NN-二氟胺。不会对亲电攻击失活的芳环优先于酰胺反应。酰胺转化成更具反应性的亚氨基醚克服了这个问题。苯丙胺和酪胺的NN-二氟衍生物的合成说明了这一点。提供了这些反应机理的证据。
• Antiplasmodial Metabolites Isolated from the Marine Octocoral <i>Muricea austera</i>
  作者：Marcelino Gutiérrez、Todd L. Capson、Héctor M. Guzmán、José González、Eduardo Ortega-Barría、Emilio Quiñoá、Ricardo Riguera

  DOI：10.1021/np060007f

  日期：2006.10.1

  Bioassay-guided fractionation of the MeOH extract from the octocoral Muricea austera collected in the Pacific coast of Panama led to the isolation of eight compounds, including three tyramine derivatives (1-3), two steroidal pregnane glycosides ( 4, 5), and three sesquiterpenoids (6-8). Compounds 2-5 are new natural products, and their structures were determined on the basis of their spectroscopic data (HRMS, 1D and 2D NMR, and CD studies). The antiprotozoal activities of the natural compounds 1-8 as well as those of a series of synthetic glycosides (11-22) and tyramine derivatives (23-35) were evaluated in vitro against a drug-resistant Plasmodium falciparum and intracellular form of Trypanosoma cruzi.
• Barger; Walpole, Journal of the Chemical Society, 1909, vol. 95, p. 1722
  作者：Barger、Walpole

  DOI：——

  日期：——