4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid methyl ester | 287202-49-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid methyl ester
• 英文别名: methyl 4-(4-but-2-ynoxyphenyl)sulfonylpiperidine-4-carboxylate
• CAS: 287202-49-7
• 化学式: C₁₇H₂₁NO₅S
• 分子量: 351.423
• InChiKey: NYKNZZCWSGCVTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid methyl ester 在 N-甲基吗啉 lithium hydroxide 、 羟胺 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 1-acetyl-4-(4-but-2-ynyloxybenzenesulfonyl)piperidine-4-carboxylic acid hydroxamide
  参考文献：
  名称：

  An efficient method to prepare α-sulfonyl hydroxamic acid derivatives

  摘要：

  alpha -Sulfonyl hydroxamic acid derivatives are biologically important molecules. An efficient protocol has bt en developed to mal;e these molecules via a direct sulfonylation of enolates. Several piperidine containing alpha -sulfonyl hydroxamic acid compounds have been prepared by this procedure. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)00835-8
• 作为产物：
  描述：

  4-but-2-ynyloxy-benzenesulfonyl fluoride 在 盐酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.5h， 生成 4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid methyl ester
  参考文献：
  名称：

  An efficient method to prepare α-sulfonyl hydroxamic acid derivatives

  摘要：

  alpha -Sulfonyl hydroxamic acid derivatives are biologically important molecules. An efficient protocol has bt en developed to mal;e these molecules via a direct sulfonylation of enolates. Several piperidine containing alpha -sulfonyl hydroxamic acid compounds have been prepared by this procedure. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)00835-8

文献信息

• Method for preparing alpha-sulfonyl hydroxamic acid derivatives
  申请人：——

  公开号：US20020099035A1

  公开（公告）日：2002-07-25

  Compounds of the formula: 1 that can be important as matrix metalloproteinase (MMP) and TNF-alpha converting enzyme (TACE) inhibitors, phosphodiesterase inhibitors, renin inhibitors, antithrombotics, and 5 -lipoxygenase inhibitors are prepared by novel methods of the present invention.

  该公式的化合物： 可以作为基质金属蛋白酶（MMP）和TNF-alpha转化酶（TACE）抑制剂、磷酸二酯酶抑制剂、肾素抑制剂、抗血栓药物和5-脂氧合酶抑制剂的重要化合物，通过本发明的新方法制备。
• Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
  申请人：American Cyanamid Company

  公开号：US06358980B1

  公开（公告）日：2002-03-19

  Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.

  该式化合物有助于治疗关节炎、肿瘤转移、组织溃疡、异常伤口愈合、牙周病、骨病、糖尿病（胰岛素抵抗）和HIV感染。
• [EN] METHOD FOR PREPARING ALPHA-SULFONYL HYDROXAMIC ACID DERIVATIVES<br/>[FR] PROCEDE POUR LA PREPARATION DE DERIVES D'ACIDE HYDROXAMIQUE ALPHA-SULFONYLE
  申请人：AMERICAN CYANAMID CO

  公开号：WO2001055112A1

  公开（公告）日：2001-08-02

  Compounds of the formula (I) that can be important as matrix metalloproteinase (MMP) and TNF-alpha converting enzyme (TACE) inhibitors, phosphodiesterase inhibitors, renin inhibitors, antithrombotics, and 5-lipoxygenase inhibitors are prepared by novel methods of the present invention.

  本发明的新方法制备出式(I)的化合物，这些化合物可以作为基质金属蛋白酶(MMP)和TNF-alpha转换酶(TACE)抑制剂、磷酸二酯酶抑制剂、肾素抑制剂、抗血栓剂和5-脂氧合酶抑制剂。
• Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/TACE inhibitors
  申请人：WYETH

  公开号：US20040229924A1

  公开（公告）日：2004-11-18

  Compounds of the formula: 1 useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.

  该式的化合物：1在治疗关节炎、肿瘤转移、组织溃疡、异常伤口愈合、牙周病、骨病、糖尿病（胰岛素抵抗）和HIV感染方面有用。
• ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS
  申请人：Wyeth Holdings Corporation

  公开号：EP1147085B1

  公开（公告）日：2005-11-16