N,N-diethylamino-2-(3',4'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthyloxymrthanone | 302587-06-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-diethylamino-2-(3',4'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthyloxymrthanone
• 英文别名: [2-(3,4-dimethoxyphenyl)-6,7-dimethoxynaphthalen-1-yl] N,N-diethylcarbamate
• CAS: 302587-06-0
• 化学式: C₂₅H₂₉NO₆
• 分子量: 439.508
• InChiKey: OKBKHFSCXDRJQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.38
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66.46
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N,N-diethylamino-2-(3',4'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthyloxymrthanone 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以41%的产率得到N,N-diethyl-6-(1'-hydroxy-6',7'-dimethoxy-2'-naphthyl)-2,3-dimethoxybenzamide
  参考文献：
  名称：

  From Phenylacetylphenylacetic Acids and 1-Benzylisoquinolines to 6,11-Dihydrobenzo[b]naphtho[2,3-d]furan-6,11-diones, 6H-Dibenzo[c,h]chroman-6-ones and 7,12-Dihydro-5H-dibenzo[c,g]chroman-5,7,12-triones via 2-Phenyl-3-hydroxy-1,4-dihydro-1,4-naphthalenediones or 2-Phenyl-1-naphthols

  摘要：

  We describe the synthesis of 6,11-dihydrobenzo[b]naphtho[2,3-d]furane 6H-Dibenzo[c,h]chroman-6-ones and 7, 12-dihydro-5H-dibenzo[c,g]chroman-5,7, 12-triones from 2-(2'-phenyl)-3-hydroxy-1,4-dihydro-1,4-naphthalenediones or 2-phenyl-1-naphthols obtained from 2-(2'-bromophenylacetyl)-phenylacetic acids or l-benzylisoquinolines. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00551-2
• 作为产物：
  描述：

  2-Methylpapaverinium iodide 在 吡啶 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 128.0h， 生成 N,N-diethylamino-2-(3',4'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthyloxymrthanone
  参考文献：
  名称：

  From Phenylacetylphenylacetic Acids and 1-Benzylisoquinolines to 6,11-Dihydrobenzo[b]naphtho[2,3-d]furan-6,11-diones, 6H-Dibenzo[c,h]chroman-6-ones and 7,12-Dihydro-5H-dibenzo[c,g]chroman-5,7,12-triones via 2-Phenyl-3-hydroxy-1,4-dihydro-1,4-naphthalenediones or 2-Phenyl-1-naphthols

  摘要：

  We describe the synthesis of 6,11-dihydrobenzo[b]naphtho[2,3-d]furane 6H-Dibenzo[c,h]chroman-6-ones and 7, 12-dihydro-5H-dibenzo[c,g]chroman-5,7, 12-triones from 2-(2'-phenyl)-3-hydroxy-1,4-dihydro-1,4-naphthalenediones or 2-phenyl-1-naphthols obtained from 2-(2'-bromophenylacetyl)-phenylacetic acids or l-benzylisoquinolines. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00551-2

文献信息

• From Phenylacetylphenylacetic Acids and 1-Benzylisoquinolines to 6,11-Dihydrobenzo[b]naphtho[2,3-d]furan-6,11-diones, 6H-Dibenzo[c,h]chroman-6-ones and 7,12-Dihydro-5H-dibenzo[c,g]chroman-5,7,12-triones via 2-Phenyl-3-hydroxy-1,4-dihydro-1,4-naphthalenediones or 2-Phenyl-1-naphthols
  作者：Elena Martı́nez、Luis Martı́nez、Mónica Treus、Juan C. Estévez、Ramón J. Estévez、Luis Castedo

  DOI：10.1016/s0040-4020(00)00551-2

  日期：2000.8

  We describe the synthesis of 6,11-dihydrobenzo[b]naphtho[2,3-d]furane 6H-Dibenzo[c,h]chroman-6-ones and 7, 12-dihydro-5H-dibenzo[c,g]chroman-5,7, 12-triones from 2-(2'-phenyl)-3-hydroxy-1,4-dihydro-1,4-naphthalenediones or 2-phenyl-1-naphthols obtained from 2-(2'-bromophenylacetyl)-phenylacetic acids or l-benzylisoquinolines. (C) 2000 Elsevier Science Ltd. All rights reserved.