bis-N,N-diethylamidocholesterylphosphite | 5559-55-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: bis-N,N-diethylamidocholesterylphosphite
• 英文别名: cholesteryl tetraethylphosphorodiamidite；Phosphorigsaeure-(cholest-5-en-3β-ylester)-bis-diethylamid；N-[diethylamino-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]phosphanyl]-N-ethylethanamine
• CAS: 5559-55-7
• 化学式: C₃₅H₆₅N₂OP
• 分子量: 560.888
• InChiKey: KKGYHEANDLOWQQ-QQCVONIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.32
• 重原子数：
  39.0
• 可旋转键数：
  13.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  15.71
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  bis-N,N-diethylamidocholesterylphosphite 生成 N-[diethylamino-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]phosphinoselenoyl]-N-ethylethanamine
  参考文献：
  名称：

  STAMATOV, STEPHAN D., CHEM. AND PHYS. LIPIDS, 50,(1989) N, C. 79-82

  摘要：

  DOI：
• 作为产物：
  描述：

  N-二(二乙基氨基)磷酰-N-乙基乙胺 、 胆固醇 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 bis-N,N-diethylamidocholesterylphosphite
  参考文献：
  名称：

  Cholesterol Thiophospholipids

  摘要：

  A method for synthesis of cyclic cholesteryl thiophosphates and amidothiophosphates was developed. These compounds were used to prepare the first representatives of a new class of cholesterol thiophospholipids: phosphocholines, phosphomethylcholamines, and phosphodiols.

  DOI：

  10.1023/b:rugc.0000025145.72937.14

文献信息

• Approaches to the Synthesis of Conjugates of Phosphocavitands and Natural Compounds
  作者：V. I. Maslennikova、R. V. Merkulov、L. K. Vasyanina、I. Bauer、D. Weber、G. Theumer、W. D. Habicher、E. E. Nifantyev

  DOI：10.1080/10426500307874

  日期：2003.7

  Possibilities for the design of phosphocavitand conjugates with natural alcohols and phenols were studied. First cavitand conjugates bearing biomolecular fragments at the periphery of the molecular cup were obtained by alcoholysis of tetrachlorophosphitocavitands and cyclophosphorylation of calix[4]resorcinarenes.

  研究了设计具有天然醇和酚的磷酸化空腔结合物的可能性。在分子杯的外围带有生物分子片段的第一个 cavitand 共轭物是通过四氯磷酸化的醇解和杯 [4] 间苯二酚的环磷酸化获得的。
• Nifant'ev,E.E. et al., Journal of general chemistry of the USSR, 1966, vol. 36, p. 327 - 329
  作者：Nifant'ev,E.E. et al.

  DOI：——

  日期：——
• Stamatov, Stephan D.; Ivanov, Stephan A., Phosphorus and Sulfur and the Related Elements, 1988, vol. 40, p. 167 - 172
  作者：Stamatov, Stephan D.、Ivanov, Stephan A.

  DOI：——

  日期：——
• Maslennikova; Merkulov; Nifant'ev, Russian Journal of General Chemistry, 1998, vol. 68, # 9, p. 1511 - 1512
  作者：Maslennikova、Merkulov、Nifant'ev

  DOI：——

  日期：——
• CTAMATOB, STEFAN DIMITROV;IVANOV, STEFAN ARAXANGELOV
  作者：CTAMATOB, STEFAN DIMITROV、IVANOV, STEFAN ARAXANGELOV

  DOI：——

  日期：——