[4H]-1,3-benzodioxin-2-carboxylic acid | 73050-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: [4H]-1,3-benzodioxin-2-carboxylic acid
• 英文别名: 4H-1,3-benzodioxine-2-carboxylic acid
• CAS: 73050-88-1
• 化学式: C₉H₈O₄
• 分子量: 180.16
• InChiKey: ICDZRZKGMHSATO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲醇 、 [4H]-1,3-benzodioxin-2-carboxylic acid 在 Redex CF resin 作用下， 生成 methyl 4H-1,3-benzodioxine-2-carboxylate
  参考文献：
  名称：

  Humbert; Dagnaux; Cohen, European Journal of Medicinal Chemistry, 1983, vol. 18, # 1, p. 67 - 78

  摘要：

  DOI：
• 作为产物：
  描述：

  二氯乙酸 、 水杨醇 在 18-冠醚-6 、 sodium hydride 、 mineral oil 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 生成 [4H]-1,3-benzodioxin-2-carboxylic acid
  参考文献：
  名称：

  Humbert; Dagnaux; Cohen, European Journal of Medicinal Chemistry, 1983, vol. 18, # 1, p. 67 - 78

  摘要：

  DOI：

文献信息

• [EN] BENZO[1,3]DIOXINE DERIVATIVES AND THEIR USE AS LPAR5 ANTAGONISTS<br/>[FR] DÉRIVÉS DE BENZO[1,3]DIOXINE ET LEUR UTILISATION COMME ANTAGONISTES DE LPAR5
  申请人：SANOFI SA

  公开号：WO2013171318A1

  公开（公告）日：2013-11-21

  The present invention relates to compounds of the formula (I), wherein the residues A, R1 to R5, Z1 and Z2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds for use in the treatment of diverse disorders, for example cardiovascular disorders like thromboembolic diseases or restenoses. The compounds of the invention are effective antagonists of the platelet LPA receptor LPAR5 (GPR92) and can in general be applied in conditions in which an undesired activation of the platelet LPA receptor LPAR5, the mast cell LPA receptor LPAR5 or the microglia cell LPA receptor LPAR5 is present or for the cure or prevention of which an inhibition of the platelet, mast cell or microglia cell LPA receptor LPAR5 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in medicaments, and pharmaceutical compositions comprising them.

  本发明涉及式(I)的化合物，其中残基A，R1到R5，Z1和Z2具有所述索引中指示的含义。式(I)的化合物是用于治疗不同疾病的有价值的药理活性化合物，例如心血管疾病，如血栓栓塞性疾病或再狭窄。本发明的化合物是血小板LPA受体LPAR5（GPR92）的有效拮抗剂，通常可应用于存在不希望的血小板LPA受体LPAR5，肥大细胞LPA受体LPAR5或微胶质细胞LPA受体LPAR5的情况，或者用于治疗或预防需要抑制血小板，肥大细胞或微胶质细胞LPA受体LPAR5的情况。本发明还涉及制备式(I)的化合物的过程，它们的用途，特别是作为药物活性成分，并包括它们的制药组合物。
• RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, COMPOUND, AND ACID DIFFUSION-CONTROLLING AGENT
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20220011665A1

  公开（公告）日：2022-01-13

  A resist composition that contains a base material component exhibiting changed solubility in a developing solution under action of acid and a compound (D0) represented by General Formula (d0), in which R 01 , R 02 , R 03 , and R 04 each independently represents a hydrogen atom, a hydroxy group, a halogen atom, or an alkyl group; alternatively, R 01 and R 02 , R 02 and R 03 , or R 03 and R 04 are bonded to each other to form an aromatic ring; R 05 represents a hydrogen atom or an alkyl group; Y represents a group that forms an alicyclic group together with a carbon atom *C; provided that at least one of the carbon atoms that form the alicyclic group is substituted with an ether bond, a thioether bond, a carbonyl group, a sulfinyl group, or a sulfonyl group; m represents an integer of 1 or more, and M m+ represents an m-valent organic cation

  一种抗蚀组合物，包含一种基础材料组分，在酸的作用下在显影溶液中表现出改变的溶解度，以及一种化合物（D0），其通式为（d0），其中R01、R02、R03和R04各自独立地代表氢原子、羟基、卤素原子或烷基；或者，R01和R02、R02和R03、或R03和R04彼此连接形成芳香环；R05代表氢原子或烷基；Y代表与碳原子*C一起形成脂环基的基团；前提是至少有一个形成脂环基的碳原子被醚键、硫醚键、羰基、亚磺酰基或磺酰基取代；m表示1或更多的整数，Mm+表示m价有机阳离子。
• Benzodioxincarboxylic acid hydrazides as insecticides
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0984009A1

  公开（公告）日：2000-03-08

  The present invention is concerned with benzodioxincarboxylic acids and esters, N'-substituted N,N'-diacylhydrazines prepared from benzodioxincarboxylic acids and esters, insecticidal compositions containing the N'-substituted N,N'-diacylhydrazines, and the use of the N'-substituted-N,N'-diacylhydrazines as insecticides.

  本发明涉及苯二氧环己烷羧酸和酯、由苯二氧环己烷羧酸和酯制备的N'-取代的N,N'-二酰基肼、含有N'-取代的N,N'-二酰基肼的杀虫组合物以及将N'-取代的N,N'-二酰基肼用作杀虫剂的用途。
• Benzo[1,3]Dioxine Derivatives And Their Use As LPAR5 Antagonists
  申请人：SANOFI

  公开号：US20150111889A1

  公开（公告）日：2015-04-23

  The present invention relates to compounds of the formula (I), wherein the residues A, R 1 to R 5 , Z 1 and Z 2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds for use in the treatment of diverse disorders, for example cardiovascular disorders like thromboembolic diseases or restenoses. The compounds of the invention are effective antagonists of the platelet LPA receptor LPAR5 (GPR92) and can in general be applied in conditions in which an undesired activation of the platelet LPA receptor LPAR5, the mast cell LPA receptor LPAR5 or the microglia cell LPA receptor LPAR5 is present or for the cure or prevention of which an inhibition of the platelet, mast cell or microglia cell LPA receptor LPAR5 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in medicaments, and pharmaceutical compositions comprising them.

  本发明涉及式（I）的化合物，其中残基A，R1至R5，Z1和Z2具有权利要求书中所示的含义。式（I）的化合物是有价值的药理活性化合物，可用于治疗多种疾病，例如心血管疾病如血栓栓塞病或再狭窄。本发明的化合物是血小板LPA受体LPAR5（GPR92）的有效拮抗剂，通常可用于存在血小板LPA受体LPAR5、肥大细胞LPA受体LPAR5或微胶质细胞LPA受体LPAR5的不良活化条件，或预防或治疗需要抑制血小板、肥大细胞或微胶质细胞LPA受体LPAR5的情况。本发明还涉及制备式（I）化合物的方法，它们的用途，特别是作为药物中的活性成分，以及包含它们的制药组合物。
• Lipogenesis inhibiting composition and process for its preparation
  申请人：——

  公开号：EP0018675A3

  公开（公告）日：1982-02-17

  This invention relates to lipogenesis inhibiting compositions and their preparation.There are provided lipogenesis inhibiting compositions comprising a pharmaceutically or verterinarily acceptable carrier associated with a benzodioxincarboxylic acid derivative of formula where the group CH3-X- is attached at the 5,6,7 or 8 -position on the benzodioxin ring system, X is an oxygen atom or a -(CHOH)- group and R is an alkyl group of from 1 to 4 carbon atoms, in a pharmaceutically or veterinarily acceptable state of purity; and the preparation of such compositions.The compositions exhibit a surprisingly effective level of lipogenesis inhibiting activity in mammals.

  本发明涉及抑制脂肪生成的组合物及其制备方法。本发明提供了抑制脂肪生成的组合物，该组合物由药用或临床上可接受的载体与式中的苯并二噁烷羧酸衍生物组成。 其中基团 CH3-X- 连接在苯并二噁烷环系的 5、6、7 或 8 位上，X 是氧原子或-(CHOH)-基团，R 是 1 至 4 个碳原子的烷基，纯度为药用或兽用可接受的状态；以及此类组合物的制备方法。