2,2,5,7,8-pentamethyl-2H-chromen-6-yl acetate | 93159-17-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,2,5,7,8-pentamethyl-2H-chromen-6-yl acetate
• 英文别名: (2,2,5,7,8-pentamethylchromen-6-yl) acetate
• CAS: 93159-17-2
• 化学式: C₁₆H₂₀O₃
• 分子量: 260.333
• InChiKey: FAXQGZNOPFLVGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2,5,7,8-pentamethyl-2H-chromen-6-yl acetate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 0.5h， 以54%的产率得到2,2,5,7,8-pentamethyl-2H-chromen-6-ol
  参考文献：
  名称：

  生物分子的自氧化。4. 最大化酚类的抗氧化活性

  摘要：

  在测量 les constantes de vitesse de l'elimination de l'hydrogene atomique par les radicaux peroxyles de l'α-tocopherol et de 35 phenols structureement manifestes。苯乙烯的自氧化抑制方法

  DOI：

  10.1021/ja00310a049
• 作为产物：
  描述：

  3,4-二氢-2,2,5,7,8-五甲基-2H-1-苯并吡喃-6-酚 在 sodium acetate 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 甲苯 为溶剂， 反应 12.5h， 生成 2,2,5,7,8-pentamethyl-2H-chromen-6-yl acetate
  参考文献：
  名称：

  生物分子的自氧化。4. 最大化酚类的抗氧化活性

  摘要：

  在测量 les constantes de vitesse de l'elimination de l'hydrogene atomique par les radicaux peroxyles de l'α-tocopherol et de 35 phenols structureement manifestes。苯乙烯的自氧化抑制方法

  DOI：

  10.1021/ja00310a049

文献信息

• Formation of chromanes and chromenes by using silver(I) or gold(I) salts or complexes
  申请人：DSM IP Assets B.V.

  公开号：EP2842951A1

  公开（公告）日：2015-03-04

  The present invention relates to the method of preparing chiral chromanes and chromenes in high yields by intramolecular hydroarylation of chiral aryl alkynes catalysed by either a silver(I) or gold(I) salt or complex in combination of a specific acid or by a silver(I) or gold(I) metal salt or complex having specific anion. By the hydroarylation a chromene is formed which has a chiral centre in the 2 position. The corresponding chromane is obtained by hydrogenation of the chromenes.

  本发明涉及通过手性芳基炔烃的分子内氢芳基化，在银(I)或金(I)盐或络合物的催化下，结合特定酸，或者通过具有特定阴离子的银(I)或金(I)金属盐或络合物，高产率地制备手性色酮和色烯的方法。通过氢芳基化形成了一个在2位具有手性中心的色烯。通过对色烯的加氢得到相应的色酮。
• [EN] FORMATION OF CHROMANES AND CHROMENES BY USING SILVER(I) OR GOLD(I) SALTS OR COMPLEXES<br/>[FR] FORMATION DE CHROMANES ET DE CHROMÈNES PAR UTILISATION DE SELS OU DE COMPLEXES D'ARGENT (I) OU D'OR (I)
  申请人：DSM IP ASSETS BV

  公开号：WO2015028463A1

  公开（公告）日：2015-03-05

  The present invention relates to the method of preparing chiral chromanes and chromenes in high yields by intramolecular hydroarylation of chiral aryl alkynes catalysed by either a silver(I) or gold(I) salt or complex in combination of a specific acid or by a silver(I) or gold(I) metal salt or complex having specific anion. By the hydroarylation a chromene is formed which has a chiral centre in the 2 position. The corresponding chromane is obtained by hydrogenation of the chromenes.

  本发明涉及通过由银(I)或金(I)盐或络合物催化的手性芳基炔烃的分子内氢芳基化，以高产率制备手性色酮和色烯的方法，或者通过具有特定酸的组合或具有特定阴离子的银(I)或金(I)金属盐或络合物。通过氢芳基化形成了一个在2位具有手性中心的色烯。通过对色烯的加氢得到相应的色酮。
• Chroman derivatives as lipoxygenase inhibitors
  申请人：Zhang Wei

  公开号：US20060193797A1

  公开（公告）日：2006-08-31

  The present invention is concerned with certain novel derivatives of Formula I: wherein X and R 1 to R 10 are as described in the specification, and where either R 5 is OH, —NR d OR a or —NR d —NR b R c , or R 7 is —NR d OR a or —NR d —NR b R c , or C═R 7 R 8 is C═NOR a or C═N—NR b R c , which may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of skin care and/or pharmaceutical compositions for the treatment of lipoxygenase mediated disorders.

  本发明涉及Formula I的某些新颖衍生物：其中X和R1至R10如规范中所述，其中R5为OH，—NRdORa或—NRd—NRbRc之一，或R7为—NRdORa或—NRd—NRbRc之一，或C═R7R8为C═NORa或C═N—NRbRc，这些可能在制造用于治疗通过脂氧合酶介导的疾病的药物组合物中有用。它们还可能在制造用于治疗脂氧合酶介导疾病的皮肤护理和/或药用组合物中有用。
• Novel tocopheryl compounds XXV: synthesis and comparison of the para-quinones of all four homologous tocopherol model compounds and their 3,4-dehydro derivatives
  作者：Anjan Patel、Thomas Netscher、Lars Gille、Kurt Mereiter、Thomas Rosenau

  DOI：10.1016/j.tet.2007.03.114

  日期：2007.6

  Four tocopherol model compounds, the chroman-6-ols (1-4) having the typical substitution pattern of alpha-, beta-, gamma-, and delta-tocopherol (vitamin E), were oxidized to the corresponding para-quinones (5-8), and dehydrogenated to the 2H-chromen-6-ols (17-20) involving initial acetyl protection of the phenolic OH and deprotection as the last step. The chromenols were also converted into the para-quinones (21-24), which existed in the bicyclic hemiketal form, in contrast to the chromanol-derived, monocyclic quinones 5-8, the ketalization behavior agreeing well with computations on the DFT level. (c) 2007 Elsevier Ltd. All rights reserved.
• FORMATION OF CHROMANES AND CHROMENES BY USING SILVER(I) OR GOLD(I) SALTS OR COMPLEXES
  申请人：DSM IP Assets B.V.

  公开号：EP3039017A1

  公开（公告）日：2016-07-06