(1H-inden-2-yl)(methyl)sulfane | 90474-74-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: (1H-inden-2-yl)(methyl)sulfane
• 英文别名: 2-(Methylthio)inden；methyl(2-indenyl)sulphide；2-methylsulfanyl-1H-indene
• CAS: 90474-74-1
• 化学式: C₁₀H₁₀S
• 分子量: 162.255
• InChiKey: SIXAUHKZSLPCGU-UHFFFAOYSA-N

物化性质

• 沸点：
  282.3±35.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  triethyloxonium fluoroborate 、 (1H-inden-2-yl)(methyl)sulfane 以 乙醚 、 硝基甲烷 为溶剂， 反应 4.0h， 以58%的产率得到Ethyl(2-indenyl)methylsulfonium-tetrafluoroborat
  参考文献：
  名称：

  Hartke, Klaus; Schilling-Pindur, Annegret, Liebigs Annalen der Chemie, 1984, # 12, p. 552 - 563

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-bis(methylsulfanyl)-1,3-dihydroindene 在 硫酸 作用下， 以 甲醇 为溶剂， 生成 (1H-inden-2-yl)(methyl)sulfane
  参考文献：
  名称：

  Hartke, Klaus; Schilling-Pindur, Annegret, Liebigs Annalen der Chemie, 1984, # 12, p. 552 - 563

  摘要：

  DOI：

文献信息

• Cesium carbonate-promoted synthesis of aryl methyl sulfides using <i>S</i>-methylisothiourea sulfate under transition-metal-free conditions
  作者：Caiyang Zhang、You Zhou、Jintao Huang、Canhui Tu、Xiaoai Zhou、Guodong Yin

  DOI：10.1039/c8ob01758a

  日期：——

  cyclopropylmethylthio groups can be easily introduced into the aromatic rings from the corresponding S-[2-(dimethylamino)ethyl]isothiourea dihydrochloride and S-cyclopropylmethylisothiourea hydrobromide. The possible reaction mechanism is proposed. It is believed that this route to aryl alkyl sulfides is well competitive with currently known methods due to its wide substrate scope, excellent yields, easy

  在碳酸铯的存在下，开发了通过芳基卤化物与可商购的S-甲基异硫脲硫酸盐反应的有效合成芳基甲基硫醚的方法。这种无味且高度结晶的固体可用作恶臭甲硫醇的替代品。在不使用柱色谱分离的情况下，克级反应也可以顺利进行。类似地，2-（二甲基氨基）乙硫基和环丙基甲硫基可容易地从相应的S- [2-（二甲氨基）乙基]异硫脲二盐酸盐和S中引入芳环。-环丙基甲基异硫脲氢溴酸盐。提出了可能的反应机理。据信，由于其广泛的底物范围，优异的收率，易于操作和无过渡金属的条件，该制备芳基烷基硫化物的方法与目前已知的方法具有很好的竞争性。
• Indenyl compounds and catalyst components for the polymerization of
  申请人：DSM N.V.

  公开号：US05646322A1

  公开（公告）日：1997-07-08

  The invention relates to an indenyl compound of the general formula R'Ind--M--(Cp)Q.sub.k in which the symbols have the following meanings: Ind: an indenyl group R': a substituent, other than hydrogen, to the Ind group, Cp: a cyclopentadienyl group M: a transition metal from group 3, 4, 5 or 6 of the Periodic System of Elements Q: a ligand to M and k is an integer linked to the valence of M. The invention is characterized in that the R' group is bound to the Ind group at the 2-position. The indenyl compound is a catalyst component for the polymerization of olefins. The invention also relates to polymers obtainable with such indenyl compounds.

  该发明涉及一种通式为R'Ind--M--(Cp)Q.sub.k的茚基化合物，其中符号具有以下含义：Ind：一个茚基；R'：一个取代基，不包括氢，连接到Ind基团；Cp：一个环戊二烯基；M：来自元素周期表第3、4、5或6族的过渡金属；Q：与M形成配体的配体，k是与M的化合价相关的整数。该发明的特征在于R'基团与Ind基团在2位结合。该茚基化合物是烯烃聚合的催化剂组分。该发明还涉及使用这种茚基化合物可获得的聚合物。
• HARTKE, K.;SCHILLING-PINDUR, A., LIEBIGS ANN. CHEM., 1984, N 3, 552-563
  作者：HARTKE, K.、SCHILLING-PINDUR, A.

  DOI：——

  日期：——
• INDENYL COMPOUNDS AND CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS
  申请人：DSM N.V.

  公开号：EP0668865B1

  公开（公告）日：2003-07-23
• 9-MEMBERED FUSED RING DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：US20180079727A1

  公开（公告）日：2018-03-22

  The purpose of the present invention is to provide novel compounds having ACC2 selective inhibitory activity. In addition, the present invention provides a pharmaceutical composition comprising the compound. A compound of Formula: or its pharmaceutically acceptable salt, wherein, R 1 is substituted or unsubstituted fused aromatic heterocyclyl represented by Formula: wherein, ring B is 5-membered ring, ring C is 6-membered ring; ring A is substituted or unsubstituted non-aromatic carbocycle or the like; -L 1 - is —O—(CR 6 R 7 )m- or the like; -L 2 - is —O—(CR 6 R 7 )n- or the like; each R 6 is independently hydrogen or the like; each R 7 is independently hydrogen or the like; each m is independently an integer of 0, 1, 2 or 3; each n is independently an integer of 1, 2 or 3; R 2 is substituted or unsubstituted alkyl; R 3 is hydrogen or substituted or unsubstituted alkyl; R 4 is substituted or unsubstituted alkylcarbonyl or the like.